Cancer Research Pole

The Cancer Research Pole gathers scientific and clinical researchers engaged in different aspects of cancer research, from fundamental research to clinical studies. Cell and organelle biology, radiobiology, molecular cancer biology, genome expression and medicinal chemistry are among the key competences found at the UNamur in the field of cancer research. Innovative and ambitious projects are developed thanks to the participation of clinicians involved in oncology treatment at the CHU UCL Namur.

Mission

The major challenge in cancer research is to better understand and overcome cancer resistance to conventional treatments such as chemotherapy and/or radiation therapy. The Cancer Research Pole therefore supports research on the mechanisms underlying cancer cell resistance, the identification of new targets, and the development of new drugs or alternative strategies to treat resistant cancers.

Research topics

Unravelling the mechanisms of resistance of cancers cells to anti-cancer treatment

  • Identification of tumor proteins responsible for cancer resistance: role of TMEM45A
  • Understanding the role of the immune system in cancer resistance: role of macrophages
  • Molecular and functional characterization of the ABCB5 transporter: a potential new tumor suppressor in melanoma
  • Development of a murine model of hepatocellular carcinoma

Development of new treatment strategies against cancers

  • Combining nanotechnology and protontherapy for a more efficient treatment of cancer: THERAPLUS
  • Optimization of radiation therapy of head and neck cancers
  • Synthesis of natural product inspired compounds with anti-cancerous properties
  • Identification of strategies to re-sensitize tumor cells resistant to chemotherapy

Publications

Cancer publications

Radiobiology publications

Multidisciplinary experts

Molecular cancer biology

GILLET Jean-Pierre, PhD, UNamur, Molecular Physiology Research Unit (URPhyM), Laboratory of Molecular Cancer Biology (LBMC)

HERMAND Damien, PhD, UNamur, Molecular Physiology Research Unit (URPhyM), Molecular Genetics (GeMo)

Cell biology

MICHIELS Carine, PhD, UNamur, Laboratory of Cellular and Molecular Biology (URBC), Tumor Hypoxia (TumHyp) group

Radiobiology and nanotechnology

HEUSKIN Anne-Catherine, PhD, UNamur, Physics of Matter and Radiation (PMR), Laboratory of Analysis by Nuclear Reaction (LARN)

LUCAS Stéphane, PhD, UNamur, Physics of Matter and Radiation (PMR), Laboratory of Analysis by Nuclear Reaction (LARN)

Medicinal chemistry & pharmacology

MASEREEL Bernard, PharmD, PhD, UNamur, Department of Pharmacy

WOUTERS Johan, PhD, UNamur, Laboratory of Structural Biological Chemistry (CBS)

Cancer imaging

VANDER BORGHT Thierry, MD, PhD, CHU UCL Namur, Godinne, Department of Nuclear Medicine

Medical oncology & hematology

D'HONDT Lionel, MD, PhD, CHU UCL Namur, Godinne, Department of Oncology

GRAUX Carlos, MD, PhD, CHU UCL Namur, Godinne, Department of Hematology

OCAK Sebahat, MD, PhD, CHU UCL Namur, Godinne, Department of Pulmonology

Radiotherapy

DAISNE Jean-François, MD, PhD, CHU UCL Namur, Sainte-Elisabeth, Department of Radiotherapy

REMOUCHAMPS Vincent, MD, PhD, CHU UCL Namur, Sainte-Elisabeth, Department of Radiotherapy