Namur Thrombosis & Hemostasis Center (NTHC)

The Namur Thrombosis & Hemostasis Center (NTHC) aims at gathering knowledge in thrombosis and hemostasis in the field of basic and clinical research, with a translational approach. It builds on synergy between the Pharmacy Department of the UNamur and different clinical disciplines involved in the management of thrombotic diseases from the CHU UCL Namur.

By working together, NTHC collaborators intend to improve public health.

  • Improve diagnosis by providing new validated tools
  • Ensure better implementation of treatments
  • Assess risk minimization strategies for the best use of the treatments
  • Have special emphasis on some orphan diseases and unmet medical need
  • Share knowledge with all stakeholders, especially patients and healthcare providers

Publications

NTHC publications

Research topics

Translational research
  • Development and validation of analytic tools for individual monitoring of Direct Oral Anticoagulants (DOACs)
  • Development and validation of analytical tools for the peri-operative management of patients treated with DOACs
  • Analytical and clinical validation of sensitive assays for the diagnosis of immune heparin-induced thrombocytopenia
  • Biomarker development: microvesicles (cancer related thrombosis, cancer resistance, paroxysmal nocturnal hemoglobinuria, heparin-induced thrombocytopenia)
Public health
  • Improvement of compliance and risk management in patients treated with DOACs
  • Study of the link between dabigatran etexilate and the risk of myocardial infarction, other cardiovascular events, major bleeding, and all-cause mortality: a systematic review and meta-analysis of randomized controlled trials
  • Study of the association between BCR-ABL Tyrosine Kinase Inhibitors for chronic myeloid leukemia and cardiovascular events, major molecular Response, and overall survival: a systematic review and meta-analysis
Basic research
  • Study of the role of extracellular vesicles as miRNAs transporters in diffuse large B cell lymphoma
  • Study of underlying mechanism of thrombosis in acute leukemia and treatment related thrombosis
  • Study of the implication of microvesicles in thrombosis in paroxysmal nocturnal hemoglobinuria and its treatments
  • Development of in vitro reference assays for the evaluation of hemocompatibility of biomaterials (stents and catheters), nanomaterials and estetrol liposomes
  • Drug development and basic pharmacology
    • Evaluation of the inactivation of human coagulation factor X by a protease of the pathogen Capnocytophaga canimorsus
    • Factor XIIa inhibitor (Ir-CPI, small molecules) development
Other topics
  • Optimization of ADAMTS13 assay for the diagnosis of microangiopathic thrombosis
  • Usefulness of flow cytometric mepacrine uptake/release combined with CD63 assay in the real time management of patients with suspected platelet dense granule disorder
  • Multicenter international studies with international societies and partners
    • Evaluation of flow cytometric assay in the diagnosis of heparin-induced thrombocytopenia
    • Standardization of diagnosis of heparin-induced thrombocytopenia using the Multiplate (ISTH)
    • Standardization of extracellular vesicle measurements on flow cytometry through vesicle size approximation (ISTH)
    • Standardization of thrombin generation test – CAT committee

Multidisciplinary experts

Medicinal chemistry & pharmacology

PI DOGNE Jean-Michel, PharmD, PhD, UNamur, Department of Pharmacy

PI MASEREEL Bernard, PharmD, PhD, UNamur, Department of Pharmacy

Post-doc DOUXFILS Jonathan, PharmD, PhD, UNamur, Department of Pharmacy

Post-doc GHELDOF Damien, MSc, PhD, UNamur, Department of Pharmacy

PhD student BOUVY Céline, MSc, UNamur, Department of Pharmacy

PhD student HAGUET Hélène, MSc, UNamur, Department of Pharmacy

PhD student MINET Valentine, PharmD, UNamur, Department of Pharmacy

PhD student WANNEZ Adeline, MSc, UNamur, Department of Pharmacy

Hematology

PI CHATELAIN Bernard, PharmD, PhD, CHU UCL Namur, Godinne, Hematology Laboratory

PI CHATELAIN Christian, MD, PhD, CHU UCL Namur, Godinne, Department of Hematology

PI GRAUX Carlos, MD, PhD, CHU UCL Namur, Godinne, Department of Hematology

PI MULLIER François, PharmD, PhD, CHU UCL Namur, Godinne, Hematology Laboratory

PhD student DEVALET Bérangère, MD, CHU UCL Namur, Godinne, Department of Hematology

MATHIEUX Valérie, MD, CHU UCL Namur, Sainte-Elisabeth, Department of Hematology 

Anesthesiology

PI GOURDIN Maximilien, MD, PhD, CHU UCL Namur, Godinne, Department of Anesthesiology

PI LESSIRE Sarah, MD, PhD, CHU UCL Namur, Godinne, Department of Anesthesiology

DINCQ Anne-Sophie, MD, CHU UCL Namur, Godinne, Department of Anesthesiology, site Godinne

General internal medicine

PhD student NICOLAS Jean-Baptiste, MD, CHU UCL Namur, Godinne, Department of General internal medicine, site Godinne

Intensive care

HORLAIT Geoffrey, MD, CHU UCL Namur, Godinne, Intensive Care Unit, site Godinne

Clinical pharmacy

PI SPINEWINE Anne, PharmD, PhD, CHU UCL Namur, Godinne, Department of Pharmacy

PhD student SENNESAEL Anne-Laure, PharmD, UNamur, Department of Pharmacy

LAROCK Anne-Sophie, PharmD, CHU UCL Namur, Godinne, Department of Pharmacy