Research

Translational research
  • Development and validation of analytic tools for individual monitoring of Direct Oral Anticoagulants (DOACs)
  • Development and validation of analytical tools for the peri-operative management of patients treated with DOACs
  • Analytical and clinical validation of sensitive assays for the diagnosis of immune heparin-induced thrombocytopenia
  • Biomarker development: microvesicles (cancer related thrombosis, cancer resistance, paroxysmal nocturnal hemoglobinuria, heparin-induced thrombocytopenia)
Public health
  • Improvement of compliance and risk management in patients treated with DOACs
  • Study of the link between dabigatran etexilate and the risk of myocardial infarction, other cardiovascular events, major bleeding, and all-cause mortality: a systematic review and meta-analysis of randomized controlled trials
  • Study of the association between BCR-ABL Tyrosine Kinase Inhibitors for chronic myeloid leukemia and cardiovascular events, major molecular Response, and overall survival: a systematic review and meta-analysis
Basic research
  • Study of the role of extracellular vesicles as miRNAs transporters in diffuse large B cell lymphoma
  • Study of underlying mechanism of thrombosis in acute leukemia and treatment related thrombosis
  • Study of the implication of microvesicles in thrombosis in paroxysmal nocturnal hemoglobinuria and its treatments
  • Development of in vitro reference assays for the evaluation of hemocompatibility of biomaterials (stents and catheters), nanomaterials and estetrol liposomes
  • Drug development and basic pharmacology
    • Evaluation of the inactivation of human coagulation factor X by a protease of the pathogen Capnocytophaga canimorsus
    • Factor XIIa inhibitor (Ir-CPI, small molecules) development
Other topics
  • Optimization of ADAMTS13 assay for the diagnosis of microangiopathic thrombosis
  • Usefulness of flow cytometric mepacrine uptake/release combined with CD63 assay in the real time management of patients with suspected platelet dense granule disorder
  • Multicenter international studies with international societies and partners
    • Evaluation of flow cytometric assay in the diagnosis of heparin-induced thrombocytopenia
    • Standardization of diagnosis of heparin-induced thrombocytopenia using the Multiplate (ISTH)
    • Standardization of extracellular vesicle measurements on flow cytometry through vesicle size approximation (ISTH)
    • Standardization of thrombin generation test – CAT committee

RESEARCH PROJECTS