Organelle biology


Demine S, Tejerina S, Bihin B, Thiry M, Reddy N, Renard P, Raes M, Jadot M, Arnould T. Mild mitochondrial uncoupling induces HSL/ATGL-independent lipolysis relying on a form of autophagy in 3T3-L1 adipocytes. J Cell Physiol. 2017 May 10.

Verdon Q, Boonen M, Ribes C, Jadot M, Gasnier B, Sagné C. SNAT7 is the primary lysosomal glutamine exporter required for extracellular protein-dependent growth of cancer cells. Proc Natl Acad Sci U S A. 2017 Apr 17.


Staudt C, Puissant E, Boonen M. Subcellular Trafficking of Mammalian Lysosomal Proteins: An Extended View. Int J Mol Sci. 2016 Dec 28;18(1).

Vannuvel K, Van Steenbrugge M, Demazy C, Ninane N, Fattaccioli A, Fransolet M, Renard P, Raes M, Arnould T. Effects of a Sublethal and Transient Stress of the Endoplasmic Reticulum on the Mitochondrial Population. J Cell Physiol. 2016 Sep;231(9):1913-31.


Arnould T, Michel S, Renard P. Mitochondria Retrograde Signaling and the UPR(mt): Where Are We in Mammals? Int J Mol Sci. 2015 Aug 6;16(8):18224-51.

Wanet A, Arnould T, Najimi M, Renard P. Connecting Mitochondria, Metabolism, and Stem Cell Fate. Stem Cells Dev. 2015 Sep 1;24(17):1957-71.

Lobet E, Letesson JJ, Arnould T. Mitochondria: A target for bacteria. Biochem Pharmacol. 2015 Apr 1;94(3):173-85.

Michel S, Canonne M, Arnould T, Renard P. Inhibition of mitochondrial genome expression triggers the activation of CHOP-10 by a cell signaling dependent on the integrated stress response but not the mitochondrial unfolded protein response. Mitochondrion. 2015 Mar;21:58-68.

Brahimi-Horn MC, Lacas-Gervais S, Adaixo R, Ilc K, Rouleau M, Notte A, Dieu M, Michiels C, Voeltzel T, Maguer-Satta V, Pelletier J, Ilie M, Hofman P, Manoury B, Schmidt A, Hiller S, Pouysségur J, Mazure NM. Local mitochondrial-endolysosomal microfusion cleaves voltage-dependent anion channel 1 to promote survival in hypoxia. Mol Cell Biol. 2015 May;35(9):1491-505.


Demine S, Reddy N, Renard P, Raes M, Arnould T Unraveling biochemical pathways affected by mitochondrial dysfunctions using metabolomic approaches. Metabolites 2014, 4:831-878.

Wanet A, Remacle N, Najar M, Sokal E, Arnould T, Najimi M, Renard P Mitochondrial remodeling in hepatic differentiation and dedifferentiation. The international journal of biochemistry & cell biology 2014, 54:174-185.

Porporato PE, Payen VL, Pérez-Escuredo J, De Saedeleer CJ, Danhier P, Copetti T, Dhup S, Tardy M, Vazeille T, Bouzin C, Feron O, Michiels C, Gallez B, Sonveaux P. A mitochondrial switch promotes tumor metastasis. Cell Rep. 2014 Aug 7;8(3):754-66.

Boonen M, Puissant E, Gilis F, Flamion B, Jadot M. Mouse liver lysosomes contain enzymatically active processed forms of Hyal-1. Biochem Biophys Res Commun. 2014 Apr 18;446(4):1155-60.

Puissant E, Gilis F, Dogné S, Flamion B, Jadot M, Boonen M. Subcellular trafficking and activity of Hyal-1 and its processed forms in murine macrophages. Traffic. 2014 May;15(5):500-15.


Van Beersel G, Jadot M, Hamer I, Arnould T Activation of sterol-responsive element binding proteins in a sucrose-induced model of lysosomal storage. The Open Pathology Journal 2013, 7:16-27.

Vannuvel K, Renard P, Raes M, Arnould T Functional and morphological impact of ER stress on mitochondriaJournal of cellular physiology 2013, 228:1802-1818.


Hamer I, Van Beersel G, Arnould T, Jadot M Lipids and lysosomes. Current drug metabolism 2012, 13:1371-1387.

De Pauw A, Demine S, Tejerina S, Dieu M, Delaive E, Kel A, Renard P, Raes M, Arnould T Mild mitochondrial uncoupling does not affect mitochondrial biogenesis but downregulates pyruvate carboxylase in adipocytes: role for triglyceride content reduction. American journal of physiology Endocrinology and metabolism 2012, 302:E1123-1141.

Demine S, Michel S, Vannuvel K, Wanet A, Renard P, Arnould T Macroautophagy and Cell Responses Related to Mitochondrial Dysfunction, Lipid Metabolism and Unconventional Secretion of Proteins (Review). Cells 2012, 1(2):168-203.

Michel S, Wanet A, De Pauw A, Rommelaere G, Arnould T, Renard P Crosstalk between mitochondrial (dys)function and mitochondrial abundance. Journal of cellular physiology 2012, 227:2297-2310.

Rommelaere G, Michel S, Malaisse J, Charlier S, Arnould T, Renard P Hypersensitivity of A8344G MERRF mutated cybrid cells to staurosporine-induced cell death is mediated by calcium-dependent activation of calpains. The international journal of biochemistry & cell biology 2012, 44:139-149.

Van Beersel G, Tihon E, Demine S, Hamer I, Jadot M, Arnould T Different molecular mechanisms involved in spontaneous and oxidative stress-induced mitochondrial fragmentation in TriPeptidyl Peptidase-1 (TPP-1) deficient fibroblasts. Bioscience reports 2012.


Hypersensitivity of mtDNA-depleted cells to staurosporine-induced apoptosis: roles of Bcl-2 downregulation and cathepsin B. Rommelaere G, Michel S, Mercy L, Fattaccioli A, Demazy C, Ninane N, Houbion A, Renard P, Arnould T. Am J Physiol Cell Physiol. 2011 May;300(5):C1090-106