Nanosciences & nanotoxicology

2017

Lozano O, Colaux JL, Laloy J, Alpan L, Dogné JM, Lucas S. Fast, asymmetric and nonhomogeneous clearance of SiC nanoaerosol assessed by micro-particle-induced x-ray emission. Nanomedicine (Lond). 2017 Nov 27.

Laloy J, Haguet H, Alpan L, Mancier V, Mejia J, Levi S, Dogné JM, Lucas S, Rousse C, Fricoteaux P. Characterization of core/shell Cu/Ag nanopowders synthesized by electrochemistry and assessment of their impact on hemolysis, platelet aggregation, and coagulation on human blood for potential wound dressing use. J Nanopart Res (2017) 19: 266.

Heuskin AC, Gallez B, Feron O, Martinive P, Michiels C, Lucas S. Metallic nanoparticles irradiated by low energy protons for radiation therapy: are there significant physical effects to enhance the dose delivery? Med Phys. 2017 May 23.

Karim R, Palazzo C, Laloy J, Delvigne AS, Vanslambrouck S, Jerome C, Lepeltier E, Orange F, Dogne JM, Evrard B, Passirani C, Piel G. Development and Evaluation of Injectable Nanosized Drug Delivery Systems for Apigenin. Int J Pharm. 2017 Apr 26.

Guerrero-Beltrán CE, Bernal-Ramírez J, Lozano O, Oropeza-Almazán Y, Castillo EC, Garza JR, García N, Vela J, García-García A, Ortega E, Torre-Amione G, Ornelas-Soto N, García-Rivas G. Silica nanoparticles induce cardiotoxicity interfering with energetic status and Ca2+ handling in adult rat cardiomyocytes. Am J Physiol Heart Circ Physiol. 2017 Apr 1;312(4):H645-H661.

Frère A, Baroni A, Hendrick E, Delvigne AS, Orange F, Peulen O, Dakwar GR, Diricq J, Dubois P, Evrard B, Remaut K, Braeckmans K, De Smedt SC, Laloy J, Dogné JM, Feller G, Mespouille L, Mottet D, Piel G. PEGylated and Functionalized Aliphatic Polycarbonate Polyplex Nanoparticles for Intravenous Administration of  HDAC5 siRNA in Cancer Therapy. ACS Appl Mater Interfaces. 2017 Jan 25;9(3):2181-2195.

Relier C, Dubreuil M, Lozano Garcia O, Cordelli E, Mejia J, Eleuteri P, Robidel F, Loret T, Pacchierotti F, Lucas S, Lacroix G, Trouiller B. Study of TiO2 P25 nanoparticles genotoxicity on lung, blood and liver cells in lung overload and non-overload conditions after repeated respiratory exposure in rats. Toxicol Sci. 2017 Apr 1;156(2):527-537.

2016

Vietti G, Ibouraadaten S, Palmai-Pallag M, Yakoub Y, Piret JP, Marbaix E, Lison D, van den Brule S. Towards predicting the lung fibrogenic activity of MWCNT: Key role of endocytosis, kinase receptors and ERK 1/2 signaling. Nanotoxicology. 2016;10(4):488-500.

Piret JP, Bondarenko OM, Boyles MS, Himly M, Ribeiro AR, Benetti F, Smal C, Lima B, Potthoff A, Simion M, Dumortier E, Leite PE, Balottin LB, Granjeiro JM, Ivask A, Kahru A, Radauer-Preiml I, Tischler U, Duschl A, Saout C, Anguissola S, Haase A, Jacobs A, Nelissen I, Misra SK, Toussaint O. Pan-European inter-laboratory studies on a panel of in vitro cytotoxicity and pro-inflammation assays for nanoparticles. Arch Toxicol. 2016 Dec 10.

Tantra R, Bouwmeester H, Bolea E, Rey-Castro C, David CA, Dogné JM, Jarman J, Laborda F, Laloy J, Robinson KN, Undas AK, van der Zande M. Suitability of analytical methods to measure solubility for the purpose of nanoregulation. Nanotoxicology. 2016;10(2):173-84.

Li S, Penninckx S, Karmani L, Heuskin AC, Watillon K, Marega R, Zola J, Corvaglia V, Genard G, Gallez B, Feron O, Martinive P, Bonifazi D, Michiels C, Lucas S. LET-dependent radiosensitization effects of gold nanoparticles for proton irradiation. Nanotechnology. 2016 Nov 11;27(45):455101.

Escamilla-Rivera V, Uribe-Ramírez M, González-Pozos S, Lozano O, Lucas S, Vizcaya-Ruiz De A. Protein corona acts as a protective shield against Fe(3)O(4)-PEG inflammation and ROS-induced toxicity in human macrophages. Toxicol Lett. 2016 Jan 5;240(1):172-84.

Contado C, Mejia J, Lozano García O, Piret JP, Dumortier E, Toussaint O, Lucas S. Physicochemical and toxicological evaluation of silica nanoparticles suitable for food and consumer products collected by following the EC recommendation. Anal Bioanal Chem. 2016 Jan;408(1):271-86.

2015

Pineux F, Marega R, Stopin A, La Torre A, Garcia Y, Devlin E, Michiels C, N Khlobystov A, Bonifazi D. Biotechnological promises of Fe-filled CNTs for cell shepherding and magnetic fluid hyperthermia applications. Nanoscale. Dec 28;7(48):20474-88.

Vietti G, Ibouraadaten S, Palmai-Pallag M, Yakoub Y, Piret JP, Marbaix E, Lison D, van den Brule S. Towards predicting the lung fibrogenic activity of MWCNT: Key role of endocytosis, kinase receptors and ERK 1/2 signaling. Nanotoxicology. 2015 Oct 7:1-13.

Levi, S., Mancier, V., Rousse, C., Garcia, O.L., Mejia, J., Guzman, M., Lucas, S., Fricoteaux, P. Synthesis of spherical copper-platinum nanoparticles by sonoelectrochemistry followed by conversion reaction (2015) Electrochimica Acta, 176, art. no. 25322, pp. 567-574.

Minet, V., Alpan, L., Mullier, F., Toussaint, O., Lucas, S., Dogné, J.-M., Laloy, J. The euglobulin clot lysis time to assess the impact of nanoparticles on fibrinolysis (2015) Journal of Nanoparticle Research, 17 (7), art. no. 317, 9 p.

Lucas S, Feron O, Gallez B, Masereel B, Michiels C, Vander Borght T. Monte Carlo Calculation of Radioimmunotherapy with (90)Y-, (177)Lu-, (131)I-, (124)I-, and (188)Re-Nanoobjects: Choice of the Best Radionuclide for Solid Tumour Treatment by Using TCP and NTCP Concepts. Comput Math Methods Med. 2015;2015:284360.

Laloy, J., Lozano, O., Alpan, L., Masereel, B., Toussaint, O., Dogné, J.M., Lucas, S. Limited inflammatory response in rats after acute exposure to a silicon carbide nanoaerosol (2015) Journal of Nanoparticle Research, 17 (8), art. no. 346, 15 p.

Toledo-Fuentes, X., Lis, D., Cecchet, F. Surface charge effects on the interaction between a solid-supported model lipid membrane and AuNPS studied by SFG spectroscopy (2015) NATO Science for Peace and Security Series B: Physics and Biophysics, 68, pp. 557-558.

Lozano Garcia O. , Colaux J. , Laloy J. , Dogne J. , Lucas S. What is the impact of Silicon Carbide nanoparticles to the mineral composition of rat lungs? A PIXE-μPIXE comparative study. J. Phys. 2015, Conference Series, Vol 617, 012016

Lozano Garcia, O. , Lison, D. , Escamilla-Rivera, V. , Mejia Mendoza, J. H. , Toussaint, O. , Dogne, J. , Lucas, S. The impact of instilled carbide nanoparticles on rat lungs: an in vivo perspective on acute intratracheal instillation. Journal of Physics, 2015, Conference Series, Vol 617, 012017

2014

J Laloy, V Minet, L Alpan, F Mullier, S Beken, O Toussaint, S Lucas and J-M Dogné. Impact of Silver Nanoparticles on Haemolysis, Platelet Function and Coagulation. Nanobiomedicine, 2014, 1:4.

Piret, J.-P., Mejia, J., Lucas, S., Zouboulis, C.C., Saout, C., Toussaint, O. Sonicated and stirred copper oxide nanoparticles induce similar toxicity and pro-inflammatory response in N-hTERT keratinocytes and SZ95 sebocytes J Nanopart Res (2014) 16:2337

Laloy J., Lozano O., Alpan L., Mejia J., Toussaint O., Masereel B., Dogné J.-M., Lucas S. Can TiC nanoparticles produce toxicity in oral administration to rats? (2014) Toxicology Reports, 1, pp. 172-187.

Laloy J, Mullier F, Alpan L, Mejia J, Lucas S, Chatelain B, Toussaint O, Masereel B, Rolin S, Dogné JM. A comparison of six major platelet functional tests to assess the impact of carbon nanomaterials on platelet function: a practical guide. Nanotoxicology. 2014 Mar;8(2):220-32.

Gontard LC, Fernandez A, Dunin-Borkowski RE, Kasama T, Lozano-Perez S, Lucas S Transmission electron microscopy of unstained hybrid Au nanoparticles capped with PPAA (plasma-poly-allylamine): Structure and electron irradiation effects. Micron (Oxford, England : 1993) 2014, 67:1-9.

Karmani L, Bouchat V, Bouzin C, Levêque P, Labar D, Bol A, Deumer G, Marega R, Bonifazi D, Haufroid V, Michiels C, Grégoire V, Feron O, Lucas S, Vander Borght T, Gallez B. (89)Zr-labeled anti-endoglin antibody-targeted gold nanoparticles for imaging cancer: implications for future cancer therapy. Nanomedicine (Lond). 2014 Sep;9(13):1923-37.

2013

Karmani L, Labar D, Valembois V, Bouchat V, Nagaswaran PG, Bol A, Gillart J, Levêque P, Bouzin C, Bonifazi D, Michiels C, Feron O, Grégoire V, Lucas S, Vander Borght T, Gallez B. Antibody-functionalized nanoparticles for imaging cancer: influence of conjugation to gold nanoparticles on the biodistribution of 89Zr-labeled cetuximab in mice. Contrast Media Mol Imaging. 2013 Sep-Oct;8(5):402-8.

V. Bouchat, N. Moreau, J. Colomer and S. Lucas. On Some Applications of Nanoparticles Synthesized in the Gas Phase by Magnetron Discharges Journal of Surface Engineered Materials and Advanced Technology, Vol. 3 No. 3, 2013, pp. 184-189.

Mejia, J., Piret, J.-P., Noël, F., Masereel, B., Toussaint, O., Lucas, S. Dose assessment of SiC nanoparticle dispersions during in vitro assays (2013) Journal of Nanoparticle Research, 15 (8), art. no. 1875

Lozano, O., Toussaint, O., Dogné, J.-M., Lucas, S. The use of PIXE for engineered nanomaterials quantification in complex matrices (2013) Journal of Physics: Conference Series, 429 (1), art. no. 012010

Lozano, O., Toussaint, O., Dogné, J.-M., Lucas, S. The use of PIXE for engineered nanomaterials quantification in complex matrices (2013) Journal of Physics: Conference Series, 429 (1), art. no. 012010

Lozano, O., Mejia, J., Piret, J.-P., Saout, C., Dogné, J.-M., Toussaint, O., Lucas, S. How does the deposited dose of oxide nanomaterials evolve in an in vitro assay? (2013) Journal of Physics: Conference Series, 429 (1), art. no. 012013

2012

Marega, R., Karmani, L., Flamant, L., Nageswaran, P.G., Valembois, V., Masereel, B., Feron, O., Borght, T.V., Lucas, S., Michiels, C., Gallez, B., Bonifazi, D. Antibody-functionalized polymer-coated gold nanoparticles targeting cancer cells: An in vitro and in vivo study (2012) Journal of Materials Chemistry, 22 (39), pp. 21305-21312.

Laloy J, Robert S, Marbehant C, Mullier F, Mejia J, Piret JP, Lucas S, Chatelain B, Dogné JM, Toussaint O, Masereel B, Rolin S. Validation of the calibrated thrombin generation test (cTGT) as the reference assay to evaluate the procoagulant activity of nanomaterials. Nanotoxicology 2012, 6:213-232.

J. Laloy, S. Robert, C. Marbehant, F. Mullier, J. Mejia, J.-P. Piret, J. Delhalle, S. Lucas, B. Chatelain, J.-M. Dogné, O. Toussaint, B. Masereel, S. Rolin, Validation of the calibrated thrombin generation test (cTGT) as the gold standard assay to assess the procoagulant activity of nanomaterials Immuno-analyse & Biologie Spécialisée, Volume 27, Issue 1, February 2012, Page 42

Lozano O, Laloy J, Alpan L, Mejia J, Rolin S, Toussaint O, Dogne JM, Lucas S, Masereel B Effects of SiC nanoparticles orally administered in a rat model: biodistribution, toxicity and elemental composition changes in feces and organsToxicology and applied pharmacology 2012, 264:232-245.

Lozano O, Mejia J, Masereel B, Toussaint O, Lison D, Lucas S Development of a PIXE analysis method for the determination of the biopersistence of SiC and TiC nanoparticles in rat lungs Nanotoxicology 2012, 6:263-271.

Lozano O, Mejia J, Tabarrant T, Masereel B, Dogne JM, Toussaint O, Lucas S Quantification of nanoparticles in aqueous food matrices using Particle-Induced X-ray Emission. Analytical and bioanalytical chemistry 2012, 403:2835-2841.

Meija J, Toussaint O, Masereel B, Lucas S Fate of SiC and TiC NPs in human reconstituted gastric fluid Nano and Biomaterials 2012, 4:Nos. 3/4.

Mejia J, Valembois V, Piret JP, Tichelaar F, Van Huis M, Masereel B, Toussaint O, Delhalle J, Mekhalif Z, Lucas S Are stirring and sonication pre-dispersion methods equivalent for in vitro toxicology evaluation of SiC and TiC? Journal of Nanoparticle Research 2012, 14:Article 815.

Mullier F, Laloy J, Robert S, Alpan L, Meija J, Piret J, Bailly N, Lucas S, Chatelain B, Toussaint O, B. Masereel, S. Rolin & JM Dogne. Assessment of different methods studying the impact of carbon nanomaterials on platelet function. Immuno-analyse Biologie Spécialisée 2012, 27:41.

Piret JP, Jacques D, Audinot JN, Mejia J, Boilan E, Noël F, Fransolet M, Demazy C, Lucas S, Saout C, Toussaint O. Copper(II) oxide nanoparticles penetrate into HepG2 cells, exert cytotoxicity via oxidative stress and induce pro-inflammatory response Nanoscale 2012, 4:7168-7184.

Piret JP, Vankoningsloo S, Mejia J, Noël F, Boilan E, Lambinon F, Zouboulis CC, Masereel B, Lucas S, Saout C, Toussaint O. Differential toxicity of copper (II) oxide nanoparticles of similar hydrodynamic diameter on human differentiated intestinal Caco-2 cell monolayers is correlated in part to copper release and shape Nanotoxicology 2012, 6:789-803.

Vankoningsloo S, Piret JP, Saout C, Noel F, Mejia J, Coquette A, Zouboulis CC, Delhalle J, Lucas S, Toussaint O. Pro-inflammatory effects of different MWCNTs dispersions in p16(INK4A)-deficient telomerase-expressing human keratinocytes but not in human SV-40 immortalized sebocytes. Nanotoxicology. 2012 Feb;6(1):77-93.

2011

V. Bouchat, N. Moreau, V. Valembois, K. Abbas, O. Feron, B. Gallez, U. Holzwarth, B. Masereel, C. Michiels, F. Simonelli, T. Vander Borght, S. Lucas. On the use of radioisotope to study the possible synthesis by magnetron sputtering of bi-metallic nanoparticles. Surface and Coatings Technology. Volume 205, Issues 21-22, 25 August 2011, Pages 4934-4940.

Virginie Bouchat, Olivier Feron, Bernard Gallez, Bernard Masereel, Carine Michiels, Thierry Vander Borght, Stéphane Lucas. Carbon nanoparticles synthesized by sputtering and gas condensation inside a nanocluster source of fixed dimension. Surface and Coatings Technology, Volume 205, Supplement 2, 25 July 2011, Pages S577–S581.

Masereel, B., Dinguizli, M., Bouzin, C., Moniotte, N., Feron, O., Gallez, B., Vander Borght, T., Michiels, C., Lucas, S. Antibody immobilization on gold nanoparticles coated layer-by-layer with polyelectrolytes (2011) Journal of Nanoparticle Research, 13 (4), pp. 1573-1580.

Crespin, M., Moreau, N., Masereel, B., Feron, O., Gallez, B., Vander Borght, T., Michiels, C., Lucas, S. Surface properties and cell adhesion onto allylamine-plasma and amine-plasma coated glass coverslips (2011) Journal of Materials Science: Materials in Medicine, 22 (3), pp. 671-682.

Piret, J.-P., Vankoningsloo, S., Noël, F., Mendoza, J.M., Lucas, S., Saout, C., Toussaint, O. Inflammation response at the transcriptional level of HepG2 cells induced by multi-walled carbon nanotubes (2011) Journal of Physics: Conference Series, 304 (1), art. no. 01204