Radiobiology & protontherapy


Penninckx S, Cekanaviciute E, Degorre C, Guiet E, Viger L, Lucas S, Costes SV. Dose, LET and Strain Dependence of Radiation-Induced 53BP1+ Foci in 15 Mouse Strains Ex Vivo Introducing Novel DNA Damage Metrics. Radiat Res. 2019 May 13.

Hespeels F, Heuskin AC, Tabarrant T, Scifoni E, Kraemer M, Chêne G, Strivay D, Lucas S. Backscattered electron emission after proton impact on gold nanoparticles with and without polymer shell coating. Phys Med Biol. 2019 Apr 15.

Belmans N, Gilles L, Virag P, Hedesiu M, Salmon B, Baatout S, Lucas S, Jacobs R, Lambrichts I, Moreels M. Method validation to assess in vivo cellular and subcellular changes in buccal mucosa cells and saliva following CBCT examinations. Dentomaxillofac Radiol. 2019 Mar 26:20180428.

Penninckx S, Heuskin AC, Michiels C, Lucas S. Thioredoxin Reductase Activity Predicts Gold Nanoparticle Radiosensitization Effect. Nanomaterials (Basel). 2019 Feb 19;9(2).

Hespeels F, Lucas S, Tabarrant T, Scifoni E, Kraemer M, Chêne G, Strivay D, Tran HN, Heuskin AC. Experimental measurements validate the use of the binary encounter approximation model to accurately compute proton induced dose and radiolysis enhancement from gold nanoparticles. Phys Med Biol. 2019 Feb 7.

Li S, Bouchy S, Penninckx S, Marega R, Fichera O, Gallez B, Feron O, Martinive P, Heuskin AC, Michiels C, Lucas S. Antibody-functionalized gold nanoparticles as tumor targeting radiosensitizers for proton therapy. Nanomedicine (Lond). 2019 Feb;14(3):317-333.


Penninckx S, Heuskin AC, Michiels C, Lucas S. The role of thioredoxin reductase in gold nanoparticle radiosensitization effects. Nanomedicine (Lond). 2018 Nov 14.

Édeline V, Remouchamps V, Isnardi V, Vander Borght T. Multimodality imaging using PET/CT ((18)F)-fluorodeoxyglucose for radiotherapy field delineation of localized Hodgkin lymphoma. Cancer Radiother. 2018 Sep;22(5):384-392.

Berriolo-Riedinger A, Becker S, Casasnovas O, Vander Borght T, Édeline V. Role of FDG PET-CT in the treatment management of Hodgkin lymphoma. Cancer Radiother. 2018 Sep;22(5):393-400.

Genard G, Wera AC, Huart C, Le Calve B, Penninckx S, Fattaccioli A, Tabarrant  T, Demazy C, Ninane N, Heuskin AC, Lucas S, Michiels C. Proton irradiation orchestrates macrophage reprogramming through NFκB signaling. Cell Death Dis. 2018 Jun 27;9(7):728.


Genard G, Lucas S, Michiels C. Reprogramming of Tumor-Associated Macrophages with Anticancer Therapies: Radiotherapy versus Chemo- and Immunotherapies. Front Immunol. 2017 Jul 14;8:828.

Heuskin AC, Gallez B, Feron O, Martinive P, Michiels C, Lucas S. Metallic nanoparticles irradiated by low energy protons for radiation therapy: are there significant physical effects to enhance the dose delivery? Med Phys. 2017 Aug;44(8):4299-4312.


Li S, Penninckx S, Karmani L, Heuskin AC, Watillon K, Marega R, Zola J, Corvaglia V, Genard G, Gallez B, Feron O, Martinive P, Bonifazi D, Michiels C, Lucas S. LET-dependent radiosensitization effects of gold nanoparticles for proton irradiation. Nanotechnology. 2016 Nov 11;27(45):455101.

Heuskin AC, Osseiran AI, Tang J, Costes SV. Simulating Space Radiation-Induced Breast Tumor Incidence Using Automata. Radiat Res. 2016 Jul;186(1):27-38.

Karmani L, Levêque P, Bouzin C, Bol A, Dieu M, Walrand S, Vander Borght T, Feron O, Grégoire V, Bonifazi D, Michiels C, Lucas S, Gallez B. Biodistribution of (125)I-labeled anti-endoglin antibody using SPECT/CT imaging: Impact of in vivo deiodination on tumor accumulation in mice. Nucl Med Biol. 2016 Mar 29;43(7):415-423.


Lucas S, Feron O, Gallez B, Masereel B, Michiels C, Vander Borght T. Monte Carlo Calculation of Radioimmunotherapy with (90)Y-, (177)Lu-, (131)I-, (124)I-, and (188)Re-Nanoobjects: Choice of the Best Radionuclide for Solid Tumour Treatment by Using TCP and NTCP Concepts. Comput Math Methods Med. 2015;2015:284360.

Riquier H, Abel D, Wera AC, Heuskin AC, Genard G, Lucas S, Michiels C. Effects of Alpha Particle and Proton Beam Irradiation as Putative Cross-Talk between A549 Cancer Cells and the Endothelial Cells in a Co-Culture System. Cancers (Basel). 2015 Mar 18;7(1):481-502.


Daisne JF, Installé J, Bihin B, Laloux M, Vander Borght T, Mathieu I, Lawson G. SPECT/CT lymphoscintigraphy of sentinel node(s) for superselective prophylactic irradiation of the neck in cN0 head and neck cancer patients: a prospective phase I feasibility study. Radiat Oncol. 2014 May 28;9:121.

Heuskin AC, Michiels C, Lucas S Low dose hypersensitivity following in vitro cell irradiation with charged particles: Is the mechanism the same as with X-ray radiation? International journal of radiation biology 2014, 90:81-89.

Gontard LC, Fernandez A, Dunin-Borkowski RE, Kasama T, Lozano-Perez S, Lucas S Transmission electron microscopy of unstained hybrid Au nanoparticles capped with PPAA (plasma-poly-allylamine): Structure and electron irradiation effects. Micron (Oxford, England : 1993) 2014, 67:1-9.

Vadhavkar, N., Pham, C., Georgescu, W., Deschamps, T., Heuskin, A.-C., Tang, J., Costes, S.V. Combinatorial DNA damage pairing model based on x-ray-induced foci predicts the dose and LET dependence of cell death in human breast cells (2014) Radiation Research, 182 (3), pp. 273-281.


Wera AC, Heuskin AC, Riquier H, Michiels C, Lucas S Low-LET proton irradiation of A549 non-small cell lung adenocarcinoma cells: dose response and RBE determination. Radiation research 2013, 179:273-281.

Heuskin AC, Wera AC, Riquier H, Michiels C, Lucas S Low-Dose Hypersensitivity and Bystander Effect are Not Mutually Exclusive in A549 Lung Carcinoma Cells after Irradiation with Charged Particles Radiation research 2013, 180:491-498.

Riquier H, Wera AC, Heuskin AC, Feron O, Lucas S, Michiels C Comparison of X-ray and alpha particle effects on a human cancer and endothelial cells: survival curves and gene expression profiles Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2013, 106:397-403.

Heuskin AC, Michiels C, Lucas S Toward computer simulation of high-LET in vitro survival curves Physics in medicine and biology 2013, 58:6495-6510.


Wéra AC, Borlon C, Nuttens VE, Riquier H, Feron O, Michiels C, Lucas S. Comparison of the clonogenic survival of A549 non-small cell lung adenocarcinoma cells after irradiation with low-dose-rate beta particles and high-dose-rate X-rays. Int J Radiat Biol. 2012 Mar;88(3):253-7.


A.-C. Wéra, H. Riquier, A.-C. Heuskin, C. Michiels, S. Lucas. In vitro irradiation station for broad beam radiobiological experiments. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Volume 269, Issue 24, 15 December 2011, Pages 3120–3124

A.-C. Heuskin, A.-C. Wéra, H. Riquier, C. Michiels, A. Bulgheroni, M. Jastrzab, M. Caccia, S. Lucas. On the comparison of three methods of assessing beam quality for broad beam in vitro cell irradiation. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Volume 269, Issue 24, 15 December 2011, Pages 3132–3136

V.Nuttens, E.Nahum and S. Lucas. An NTCP Analysis of Urethral Complications from Low Doserate Mono- and Bi-Radionuclide Brachytherapy. Prostate Cancer. Volume 2011 (2011), Article ID 128360, 9 pages.