Organelle biology

Publications

2020

Canonne M, Wanet A, Nguyen TTA, Khelfi A, Ayama-Canden S, Van Steenbrugge M, Fattaccioli A, Sokal E, Najimi M, Arnould T, Renard P. MPV17 does not control cancer cell proliferation. PLoS One. 2020 Mar 10;15(3):e0229834.

Tannous A, Boonen M, Zheng H, Zhao C, Germain CJ, Moore DF, Sleat DE, Jadot M, Lobel P. Comparative Analysis of Quantitative Mass Spectrometric Methods for Subcellular Proteomics. J Proteome Res. 2020 Mar 5.

2019

Storder J, Renard P, Arnould T. Update on the role of Sirtuin 3 in cell differentiation: a major metabolic target that can be pharmacologically controlled. Biochem Pharmacol. 2019 Nov;169:113621.

Demine S, Renard P, Arnould T. Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases. Cells. 2019 Jul 30;8(8).

Raas Q, Saih FE, Gondcaille C, Trompier D, Hamon Y, Leoni V, Caccia C, Nasser B, Jadot M, Ménétrier F, Lizard G, Cherkaoui-Malki M, Andreoletti P, Savary S. A microglial cell model for acyl-CoA oxidase 1 deficiency. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Apr;1864(4):567-576.

2018

Lobet E, Willemart K, Ninane N, Demazy C, Sedzicki J, Lelubre C, De Bolle X, Renard P, Raes M, Dehio C, Letesson JJ, Arnould T. Mitochondrial fragmentation affects neither the sensitivity to TNFα-induced apoptosis of Brucella-infected cells nor the intracellular replication of the bacteria. Sci Rep. 2018 Mar 26;8(1):5173.

Demine S, Tejerina S, Bihin B, Thiry M, Reddy N, Renard P, Raes M, Jadot M, Arnould T. Mild mitochondrial uncoupling induces HSL/ATGL-independent lipolysis relying on a form of autophagy in 3T3-L1 adipocytes. J Cell Physiol. 2018 Feb;233(2):1247-1265.

Castrogiovanni C, Waterschoot B, De Backer O, Dumont P. Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis. Cell Death Differ. 2018 Jan;25(1):190-203.

2017

Wanet A, Caruso M, Domelevo Entfellner JB, Najar M, Fattaccioli A, Demazy C,Evraerts J, El-Kehdy H, Pourcher G, Sokal E, Arnould T, Tiffin N, Najimi M, Renard P. The Transcription Factor 7-Like 2-Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Axis Connects Mitochondrial Biogenesis and Metabolic Shift with Stem Cell Commitment to Hepatic Differentiation. Stem Cells. 2017 Oct;35(10):2184-2197.

Verdon Q, Boonen M, Ribes C, Jadot M, Gasnier B, Sagné C. SNAT7 is the primary lysosomal glutamine exporter required for extracellular protein-dependent growth of cancer cells. Proc Natl Acad Sci U S A. 2017 Apr 17.

Jadot M, Boonen M, Thirion J, Wang N, Xing J, Zhao C, Tannous A, Qian M, Zheng H, Everett JK, Moore DF, Sleat DE, Lobel P. Accounting for Protein Subcellular Localization: A Compartmental Map of the Rat Liver Proteome. Mol Cell Proteomics. 2017 Feb;16(2):194-212.

2016

Puissant E, Boonen M. Monocytes/Macrophages Upregulate the Hyaluronidase HYAL1 and Adapt Its Subcellular Trafficking to Promote Extracellular Residency upon Differentiation into Osteoclasts. PLoS One. 2016 Oct 18;11(10):e0165004.

Boonen M, Staudt C, Gilis F, Oorschot V, Klumperman J, Jadot M. Cathepsin D and its newly identified transport receptor SEZ6L2 can modulate neurite outgrowth. J Cell Sci. 2016 Feb 1;129(3):557-68.

Staudt C, Puissant E, Boonen M. Subcellular Trafficking of Mammalian Lysosomal Proteins: An Extended View. Int J Mol Sci. 2016 Dec 28;18(1).

Staudt C, Gilis F, Tevel V, Jadot M, Boonen M. A conserved glycine residue in the C-terminal region of human ATG9A is required for its transport from the endoplasmic reticulum to the Golgi apparatus. Biochem Biophys Res Commun. 2016 Oct 14;479(2):404-409.

Staudt C, Gilis F, Boonen M, Jadot M. Molecular determinants that mediate the sorting of human ATG9A from the endoplasmic reticulum. Biochim Biophys Acta. 2016 Sep;1863(9):2299-310.

Vannuvel K, Van Steenbrugge M, Demazy C, Ninane N, Fattaccioli A, Fransolet M, Renard P, Raes M, Arnould T. Effects of a Sublethal and Transient Stress of the Endoplasmic Reticulum on the Mitochondrial Population. J Cell Physiol. 2016 Sep;231(9):1913-31.

2015

Arnould T, Michel S, Renard P. Mitochondria Retrograde Signaling and the UPR(mt): Where Are We in Mammals? Int J Mol Sci. 2015 Aug 6;16(8):18224-51.

Wanet A, Arnould T, Najimi M, Renard P. Connecting Mitochondria, Metabolism, and Stem Cell Fate. Stem Cells Dev. 2015 Sep 1;24(17):1957-71.

Lobet E, Letesson JJ, Arnould T. Mitochondria: A target for bacteria. Biochem Pharmacol. 2015 Apr 1;94(3):173-85.

Michel S, Canonne M, Arnould T, Renard P. Inhibition of mitochondrial genome expression triggers the activation of CHOP-10 by a cell signaling dependent on the integrated stress response but not the mitochondrial unfolded protein response. Mitochondrion. 2015 Mar;21:58-68.

Brahimi-Horn MC, Lacas-Gervais S, Adaixo R, Ilc K, Rouleau M, Notte A, Dieu M, Michiels C, Voeltzel T, Maguer-Satta V, Pelletier J, Ilie M, Hofman P, Manoury B, Schmidt A, Hiller S, Pouysségur J, Mazure NM. Local mitochondrial-endolysosomal microfusion cleaves voltage-dependent anion channel 1 to promote survival in hypoxia. Mol Cell Biol. 2015 May;35(9):1491-505.

2014

Demine S, Reddy N, Renard P, Raes M, Arnould T Unraveling biochemical pathways affected by mitochondrial dysfunctions using metabolomic approaches. Metabolites 2014, 4:831-878.

Wanet A, Remacle N, Najar M, Sokal E, Arnould T, Najimi M, Renard P Mitochondrial remodeling in hepatic differentiation and dedifferentiation. The international journal of biochemistry & cell biology 2014, 54:174-185.

Porporato PE, Payen VL, Pérez-Escuredo J, De Saedeleer CJ, Danhier P, Copetti T, Dhup S, Tardy M, Vazeille T, Bouzin C, Feron O, Michiels C, Gallez B, Sonveaux P. A mitochondrial switch promotes tumor metastasis. Cell Rep. 2014 Aug 7;8(3):754-66.

Boonen M, Puissant E, Gilis F, Flamion B, Jadot M. Mouse liver lysosomes contain enzymatically active processed forms of Hyal-1. Biochem Biophys Res Commun. 2014 Apr 18;446(4):1155-60.

Puissant E, Gilis F, Dogné S, Flamion B, Jadot M, Boonen M. Subcellular trafficking and activity of Hyal-1 and its processed forms in murine macrophages. Traffic. 2014 May;15(5):500-15.

2013

Van Beersel G, Jadot M, Hamer I, Arnould T Activation of sterol-responsive element binding proteins in a sucrose-induced model of lysosomal storage. The Open Pathology Journal 2013, 7:16-27.

Vannuvel K, Renard P, Raes M, Arnould T Functional and morphological impact of ER stress on mitochondriaJournal of cellular physiology 2013, 228:1802-1818.

2012

Hamer I, Van Beersel G, Arnould T, Jadot M Lipids and lysosomes. Current drug metabolism 2012, 13:1371-1387.

De Pauw A, Demine S, Tejerina S, Dieu M, Delaive E, Kel A, Renard P, Raes M, Arnould T Mild mitochondrial uncoupling does not affect mitochondrial biogenesis but downregulates pyruvate carboxylase in adipocytes: role for triglyceride content reduction. American journal of physiology Endocrinology and metabolism 2012, 302:E1123-1141.

Demine S, Michel S, Vannuvel K, Wanet A, Renard P, Arnould T Macroautophagy and Cell Responses Related to Mitochondrial Dysfunction, Lipid Metabolism and Unconventional Secretion of Proteins (Review). Cells 2012, 1(2):168-203.

Michel S, Wanet A, De Pauw A, Rommelaere G, Arnould T, Renard P Crosstalk between mitochondrial (dys)function and mitochondrial abundance. Journal of cellular physiology 2012, 227:2297-2310.

Rommelaere G, Michel S, Malaisse J, Charlier S, Arnould T, Renard P Hypersensitivity of A8344G MERRF mutated cybrid cells to staurosporine-induced cell death is mediated by calcium-dependent activation of calpains. The international journal of biochemistry & cell biology 2012, 44:139-149.

Van Beersel G, Tihon E, Demine S, Hamer I, Jadot M, Arnould T Different molecular mechanisms involved in spontaneous and oxidative stress-induced mitochondrial fragmentation in TriPeptidyl Peptidase-1 (TPP-1) deficient fibroblasts. Bioscience reports 2012.

2011

Hypersensitivity of mtDNA-depleted cells to staurosporine-induced apoptosis: roles of Bcl-2 downregulation and cathepsin B. Rommelaere G, Michel S, Mercy L, Fattaccioli A, Demazy C, Ninane N, Houbion A, Renard P, Arnould T. Am J Physiol Cell Physiol. 2011 May;300(5):C1090-106