NAmur Research Institute for LIfe Sciences
Sebahat Ocak
Lung cancer & Interventional pneumology
Prof. Sebahat Ocak MD, PhD
CHU UCL Namur, Site Godinne, Department of Pneumology
Member of Institute of Experimental and Clinical Research (IREC), UCLouvain
Expertise and research interests
Lung cancer & Interventional pneumology
Site principal investigator of clinical trials (sponsored and academic) in the field of thoracic oncology at CHU UCL Namur (Site Godinne)
Research projects
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In collaboration with UNamur
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- Focal Adhesion Kinase activation in small cell lung cancer: mechanisms, prognostic implication, and therapeutic potential of its inhibition. Ongoing PhD thesis by
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Role of Focal Adhesion Kinase in the invasive phenotype of small-cell lung cancer. PhD thesis defended by Dr. Frank Aboubakar Nana on 16/07/2020. Under co-supervision by Prof. Sebahat Ocak, CHU UCL Namur and Prof. Charles Pilette, Cliniques Universitaires St-Luc.
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Molecular determinants of lung cancer progression : functional implications of the Polymeric Immunoglobulin Receptor and the Focal Adhesion Kinase. PhD thesis defended by Prof. Sebahat Ocak on 06/09/2012. Under co-supervision by Prof. Yves Sibille, UCLouvain, CHU UCL Namur and Prof. Pierre Massion, Vanderbilt University.
Selected publications
Mauclet C, Dupont MV, Roelandt K, Regnier M, Delos M, Pirard L, Vander Borght T, Dahlqvist C, Froidure A, Rondelet B, Vanderick J, Remouchamps V, Duplaquet F, Ocak S. Treatment and Prognosis of Patients with Lung Cancer and Combined Interstitial Lung Disease. Cancers (Basel). 2023 Jul 30;15(15):3876.
Nana FA, Lamberts V, Hoton D, Stanciu CP, Lecocq M, Carlier FM, Duplaquet F, Pirard L, Pilette C, Bihin B, Ocak S. Restin protein expression in non-small cell lung cancer. Thorac Cancer. 2023 Jun 26.
Mahiat C, Bihin B, Duplaquet F, Stanciu Pop C, Dupont M, Vander Borght T, Rondelet B, Vanderick J, André B, Pirard L, Ocak S. Systemic Inflammation/Nutritional Status Scores Are Prognostic but Not Predictive in Metastatic Non-Small-Cell Lung Cancer Treated with First-Line Immune Checkpoint Inhibitors. Int J Mol Sci. 2023 Feb 10;24(4):3618.
Pasau T, Wauters E, Wauters I, Duplaquet F, Pirard L, Pop-Stanciu C, D'Haene N, Dupont M, Vander Borght T, Rondelet B, Ocak S. Case report: BRAF A598-T599insV mutation as a potential resistance mechanism to alectinib in ALK-rearranged lung adenocarcinoma. Front Oncol. 2022 Nov 7;12:985446.
Ocak S, Tournoy K, Berghmans T, Demedts I, Durieux R, Janssens A, Moretti L, Nackaerts K, Pieters T, Surmont V, Van Eycken L, Vrijens F, Weynand B, van Meerbeeck JP. Lung Cancer in Belgium. J Thorac Oncol. 2021 Oct;16(10):1610-1621.
Aboubakar Nana F, Ocak S. Targeting BRAF Activation as Acquired Resistance Mechanism to EGFR Tyrosine Kinase Inhibitors in EGFR-Mutant Non-Small-Cell Lung Cancer. Pharmaceutics. 2021 Sep 15;13(9):1478.
Aboubakar Nana F, Vanderputten M, Ocak S. Role of Focal Adhesion Kinase in Small-Cell Lung Cancer and Its Potential as a Therapeutic Target. Cancers (Basel). 2019 Oct 29;11(11):1683.
Aboubakar Nana F, Lecocq M, Ladjemi MZ, Detry B, Dupasquier S, Feron O, Massion PP, Sibille Y, Pilette C, Ocak S. Therapeutic Potential of Focal Adhesion Kinase Inhibition in Small Cell Lung Cancer. Mol Cancer Ther. 2019 Jan;18(1):17-27.
Aboubakar Nana F, Hoton D, Ambroise J, Lecocq M, Vanderputten M, Sibille Y, Vanaudenaerde B, Pilette C, Bouzin C, Ocak S. Increased Expression and Activation of FAK in Small-Cell Lung Cancer Compared to Non-Small-Cell Lung Cancer. Cancers (Basel). 2019 Oct 10;11(10):1526.
Mauclet C, Duplaquet F, Pirard L, Rondelet B, Dupont M, Pop-Stanciu C, Vander Borght T, Remmelink M, D'Haene N, Lambin S, Wanet M, Remouchamps V, Ocak S. Complete tumor response of a locally advanced lung large-cell neuroendocrine carcinoma after palliative thoracic radiotherapy and immunotherapy with nivolumab. Lung Cancer. 2019 Feb;128:53-56.
Ocak S, Duplaquet F, Jamart J, Pirard L, Weynand B, Delos M, Eucher P, Rondelet B, Dupont M, Delaunois L, Sibille Y, Dahlqvist C. Diagnostic Accuracy and Safety of CT-Guided Percutaneous Transthoracic Needle Biopsies: 14-Gauge versus 22-Gauge Needles. J Vasc Interv Radiol. 2016 May;27(5):674-81.
Ocak S, Friedman DB, Chen H, Ausborn JA, Hassanein M, Detry B, Weynand B, Aboubakar F, Pilette C, Sibille Y, Massion PP. Discovery of new membrane-associated proteins overexpressed in small-cell lung cancer. J Thorac Oncol. 2014 Mar;9(3):324-36.
Ocak S, Chen H, Callison C, Gonzalez AL, Massion PP. Expression of focal adhesion kinase in small-cell lung carcinoma. Cancer. 2012 Mar 1;118(5):1293-301.
Ocak S, Pedchenko TV, Chen H, Qian J, Vasiliy Polosukhin V, Harris FT, Pilette C, Sibille Y, Gonzalez AL, Massion PP. Loss of polymeric immunoglobulin receptor expression promotes lung tumorigenesis. Eur Respir J. 2012 May;39(5):1171-80.
Ocak S, Yamashita H, Udyavar AR, Miller AN, Gonzalez AL, Zou Y, Jiang A, Yi Y, Shyr Y, Estrada L, Quaranta V, Massion PP. DNA copy number aberrations in small-cell lung cancer reveal activation of the focal adhesion pathway. Oncogene. 2010 Dec 2;29(48):6331-42.
