Organelle & membrane biology



Juszczak F, Arnould T, Declèves AE. The Role of Mitochondrial Sirtuins (SIRT3, SIRT4 and SIRT5) in Renal Cell Metabolism: Implication for Kidney Diseases. Int J Mol Sci. 2024 Jun 25;25(13):6936.

Van den Bossche F, Tevel V, Gilis F, Gaussin JF, Boonen M, Jadot M. Residence of the Nucleotide Sugar Transporter Family Members SLC35F1 and SLC35F6 in the Endosomal/Lysosomal Pathway. Int J Mol Sci. 2024 Jun 18;25(12):6718.

He N, Depta L, Rossetti C, Caramelle L, Cigler M, Bryce-Rogers HP, Michon M, Rafn Dan O, Hoock J, Barbier J, Gillet D, Forrester A, Winter GE, Laraia L. Inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation. Nat Chem Biol. 2024 Jun 21.

Cigler M, Imrichova H, Frommelt F, Caramelle L, Depta L, Rukavina A, Kagiou C, Hannich JT, Mayor-Ruiz C, Superti-Furga G, Sievers S, Forrester A, Laraia L, Waldmann H, Winter GE. Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP. Nat Chem Biol. 2024 Jun 21.

Robinson CM, Duggan A, Forrester A. ER exit in physiology and disease. Front Mol Biosci. 2024 Jan 18;11:1352970.


Ledoux B, Zanin N, Yang J, Mercier V, Coster C, Dupont-Gillain C, Alsteens D, Morsomme P, Renard HF. Plasma membrane nanodeformations promote actin polymerization through CIP4/CDC42 recruitment and regulate type II IFN signaling. Sci Adv. 2023 Dec 15;9(50):eade1660.

Verbeke J, De Bolle X, Arnould T. When mitophagy dictates the outcome of cellular infection: the case of Brucella abortus. Autophagy. 2023 Nov;19(11):3022-3023.

Detraux D, Caruso M, Feller L, Fransolet M, Meurant S, Mathieu J, Arnould T, Renard P. A critical role for heme synthesis and succinate in the regulation of pluripotent states transitions. Elife. 2023 Jul 10;12:e78546.

Amato I, Meurant S, Renard P. The Key Role of Mitochondria in Somatic Stem Cell Differentiation: From Mitochondrial Asymmetric Apportioning to Cell Fate. Int J Mol Sci. 2023 Jul 29;24(15):12181.

Verbeke J, De Bolle X, Arnould T. To eat or not to eat mitochondria? How do host cells cope with mitophagy upon bacterial infection? PLoS Pathog. 2023 Jul 6;19(7):e1011471.

Meurant S, Mauclet L, Dieu M, Arnould T, Eyckerman S, Renard P. Endogenous TOM20 Proximity Labeling: A Swiss-Knife for the Study of Mitochondrial Proteins in Human Cells. Int J Mol Sci. 2023 May 31;24(11):9604.

Wu Y, Taisne C, Mahtal N, Forrester A, Lussignol M, Cintrat JC, Esclatine A, Gillet D, Barbier J. Autophagic Degradation Is Involved in Cell Protection against Ricin Toxin. Toxins (Basel). 2023 Apr 23;15(5):304.

Verbeke J, Fayt Y, Martin L, Yilmaz O, Sedzicki J, Reboul A, Jadot M, Renard P, Dehio C, Renard HF, Letesson JJ, De Bolle X, Arnould T. Host cell egress of Brucella abortus requires BNIP3L-mediated mitophagy. EMBO J. 2023 Jul 17;42(14):e112817.

Lemaigre C, Ceuppens A, Valades-Cruz CA, Ledoux B, Vanbeneden B, Hassan M, Zetterberg FR, Nilsson UJ, Johannes L, Wunder C, Renard HF, Morsomme P. N-BAR and F-BAR proteins - Endophilin-A3 and PSTPIP1 - control clathrin-independent endocytosis of L1CAM. Traffic. 2023 Apr;24(4):190-212.


Detraux D, Renard P. Succinate as a New Actor in Pluripotency and Early Development? Metabolites. 2022 Jul 15;12(7):651.

Tyckaert F, Zanin N, Morsomme P, Renard HF. Rac1, actin cytoskeleton and microtubules are key players in clathrin-independent endophilin-A3-mediated endocytosis. J Cell Sci. 2022 Jun 15:jcs.259623.

McKay LGA, Thomas J, Albalawi W, Fattaccioli A, Dieu M, Ruggiero A, McKeating JA, Ball JK, Tarr AW, Renard P, Pollakis G, Paxton WA. The HCV Envelope Glycoprotein Down-Modulates NF-κB Signalling and Associates With Stimulation of the Host Endoplasmic Reticulum Stress Pathway. Front Immunol. 2022 Mar 15;13:831695.


Renard HF, Boucrot E. Unconventional endocytic mechanisms. Curr Opin Cell Biol. 2021 Apr 13;71:120-129.

Colin M, Dechêne L, Ceusters J, Niesten A, Demazy C, Lagneaux L, Zouaoui Boudjeltia K, Franck T, Van Antwerpen P, Renard P, Mathieu V, Serteyn D. Priming of mesenchymal stem cells with a hydrosoluble form of curcumin allows keeping their mesenchymal properties for cell-based therapy development. J Cell Mol Med. 2021 May;25(10):4877-4881.


Canonne M, Wanet A, Nguyen TTA, Khelfi A, Ayama-Canden S, Van Steenbrugge M, Fattaccioli A, Sokal E, Najimi M, Arnould T, Renard P. MPV17 does not control cancer cell proliferation. PLoS One. 2020 Mar 10;15(3):e0229834.

Tannous A, Boonen M, Zheng H, Zhao C, Germain CJ, Moore DF, Sleat DE, Jadot M, Lobel P. Comparative Analysis of Quantitative Mass Spectrometric Methods for Subcellular Proteomics. J Proteome Res. 2020 Mar 5.


Storder J, Renard P, Arnould T. Update on the role of Sirtuin 3 in cell differentiation: a major metabolic target that can be pharmacologically controlled. Biochem Pharmacol. 2019 Nov;169:113621.

Demine S, Renard P, Arnould T. Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases. Cells. 2019 Jul 30;8(8).

Raas Q, Saih FE, Gondcaille C, Trompier D, Hamon Y, Leoni V, Caccia C, Nasser B, Jadot M, Ménétrier F, Lizard G, Cherkaoui-Malki M, Andreoletti P, Savary S. A microglial cell model for acyl-CoA oxidase 1 deficiency. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Apr;1864(4):567-576.


Lobet E, Willemart K, Ninane N, Demazy C, Sedzicki J, Lelubre C, De Bolle X, Renard P, Raes M, Dehio C, Letesson JJ, Arnould T. Mitochondrial fragmentation affects neither the sensitivity to TNFα-induced apoptosis of Brucella-infected cells nor the intracellular replication of the bacteria. Sci Rep. 2018 Mar 26;8(1):5173.

Demine S, Tejerina S, Bihin B, Thiry M, Reddy N, Renard P, Raes M, Jadot M, Arnould T. Mild mitochondrial uncoupling induces HSL/ATGL-independent lipolysis relying on a form of autophagy in 3T3-L1 adipocytes. J Cell Physiol. 2018 Feb;233(2):1247-1265.

Castrogiovanni C, Waterschoot B, De Backer O, Dumont P. Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis. Cell Death Differ. 2018 Jan;25(1):190-203.


Wanet A, Caruso M, Domelevo Entfellner JB, Najar M, Fattaccioli A, Demazy C,Evraerts J, El-Kehdy H, Pourcher G, Sokal E, Arnould T, Tiffin N, Najimi M, Renard P. The Transcription Factor 7-Like 2-Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Axis Connects Mitochondrial Biogenesis and Metabolic Shift with Stem Cell Commitment to Hepatic Differentiation. Stem Cells. 2017 Oct;35(10):2184-2197.

Verdon Q, Boonen M, Ribes C, Jadot M, Gasnier B, Sagné C. SNAT7 is the primary lysosomal glutamine exporter required for extracellular protein-dependent growth of cancer cells. Proc Natl Acad Sci U S A. 2017 Apr 17.

Jadot M, Boonen M, Thirion J, Wang N, Xing J, Zhao C, Tannous A, Qian M, Zheng H, Everett JK, Moore DF, Sleat DE, Lobel P. Accounting for Protein Subcellular Localization: A Compartmental Map of the Rat Liver Proteome. Mol Cell Proteomics. 2017 Feb;16(2):194-212.


Puissant E, Boonen M. Monocytes/Macrophages Upregulate the Hyaluronidase HYAL1 and Adapt Its Subcellular Trafficking to Promote Extracellular Residency upon Differentiation into Osteoclasts. PLoS One. 2016 Oct 18;11(10):e0165004.

Boonen M, Staudt C, Gilis F, Oorschot V, Klumperman J, Jadot M. Cathepsin D and its newly identified transport receptor SEZ6L2 can modulate neurite outgrowth. J Cell Sci. 2016 Feb 1;129(3):557-68.

Staudt C, Puissant E, Boonen M. Subcellular Trafficking of Mammalian Lysosomal Proteins: An Extended View. Int J Mol Sci. 2016 Dec 28;18(1).

Staudt C, Gilis F, Tevel V, Jadot M, Boonen M. A conserved glycine residue in the C-terminal region of human ATG9A is required for its transport from the endoplasmic reticulum to the Golgi apparatus. Biochem Biophys Res Commun. 2016 Oct 14;479(2):404-409.

Staudt C, Gilis F, Boonen M, Jadot M. Molecular determinants that mediate the sorting of human ATG9A from the endoplasmic reticulum. Biochim Biophys Acta. 2016 Sep;1863(9):2299-310.

Vannuvel K, Van Steenbrugge M, Demazy C, Ninane N, Fattaccioli A, Fransolet M, Renard P, Raes M, Arnould T. Effects of a Sublethal and Transient Stress of the Endoplasmic Reticulum on the Mitochondrial Population. J Cell Physiol. 2016 Sep;231(9):1913-31.


Arnould T, Michel S, Renard P. Mitochondria Retrograde Signaling and the UPR(mt): Where Are We in Mammals? Int J Mol Sci. 2015 Aug 6;16(8):18224-51.

Wanet A, Arnould T, Najimi M, Renard P. Connecting Mitochondria, Metabolism, and Stem Cell Fate. Stem Cells Dev. 2015 Sep 1;24(17):1957-71.

Lobet E, Letesson JJ, Arnould T. Mitochondria: A target for bacteria. Biochem Pharmacol. 2015 Apr 1;94(3):173-85.

Michel S, Canonne M, Arnould T, Renard P. Inhibition of mitochondrial genome expression triggers the activation of CHOP-10 by a cell signaling dependent on the integrated stress response but not the mitochondrial unfolded protein response. Mitochondrion. 2015 Mar;21:58-68.

Brahimi-Horn MC, Lacas-Gervais S, Adaixo R, Ilc K, Rouleau M, Notte A, Dieu M, Michiels C, Voeltzel T, Maguer-Satta V, Pelletier J, Ilie M, Hofman P, Manoury B, Schmidt A, Hiller S, Pouysségur J, Mazure NM. Local mitochondrial-endolysosomal microfusion cleaves voltage-dependent anion channel 1 to promote survival in hypoxia. Mol Cell Biol. 2015 May;35(9):1491-505.


Demine S, Reddy N, Renard P, Raes M, Arnould T Unraveling biochemical pathways affected by mitochondrial dysfunctions using metabolomic approaches. Metabolites 2014, 4:831-878.

Wanet A, Remacle N, Najar M, Sokal E, Arnould T, Najimi M, Renard P Mitochondrial remodeling in hepatic differentiation and dedifferentiation. The international journal of biochemistry & cell biology 2014, 54:174-185.

Porporato PE, Payen VL, Pérez-Escuredo J, De Saedeleer CJ, Danhier P, Copetti T, Dhup S, Tardy M, Vazeille T, Bouzin C, Feron O, Michiels C, Gallez B, Sonveaux P. A mitochondrial switch promotes tumor metastasis. Cell Rep. 2014 Aug 7;8(3):754-66.

Boonen M, Puissant E, Gilis F, Flamion B, Jadot M. Mouse liver lysosomes contain enzymatically active processed forms of Hyal-1. Biochem Biophys Res Commun. 2014 Apr 18;446(4):1155-60.

Puissant E, Gilis F, Dogné S, Flamion B, Jadot M, Boonen M. Subcellular trafficking and activity of Hyal-1 and its processed forms in murine macrophages. Traffic. 2014 May;15(5):500-15.


Van Beersel G, Jadot M, Hamer I, Arnould T Activation of sterol-responsive element binding proteins in a sucrose-induced model of lysosomal storage. The Open Pathology Journal 2013, 7:16-27.

Vannuvel K, Renard P, Raes M, Arnould T Functional and morphological impact of ER stress on mitochondriaJournal of cellular physiology 2013, 228:1802-1818.


Hamer I, Van Beersel G, Arnould T, Jadot M Lipids and lysosomes. Current drug metabolism 2012, 13:1371-1387.

De Pauw A, Demine S, Tejerina S, Dieu M, Delaive E, Kel A, Renard P, Raes M, Arnould T Mild mitochondrial uncoupling does not affect mitochondrial biogenesis but downregulates pyruvate carboxylase in adipocytes: role for triglyceride content reduction. American journal of physiology Endocrinology and metabolism 2012, 302:E1123-1141.

Demine S, Michel S, Vannuvel K, Wanet A, Renard P, Arnould T Macroautophagy and Cell Responses Related to Mitochondrial Dysfunction, Lipid Metabolism and Unconventional Secretion of Proteins (Review). Cells 2012, 1(2):168-203.

Michel S, Wanet A, De Pauw A, Rommelaere G, Arnould T, Renard P Crosstalk between mitochondrial (dys)function and mitochondrial abundance. Journal of cellular physiology 2012, 227:2297-2310.

Rommelaere G, Michel S, Malaisse J, Charlier S, Arnould T, Renard P Hypersensitivity of A8344G MERRF mutated cybrid cells to staurosporine-induced cell death is mediated by calcium-dependent activation of calpains. The international journal of biochemistry & cell biology 2012, 44:139-149.

Van Beersel G, Tihon E, Demine S, Hamer I, Jadot M, Arnould T Different molecular mechanisms involved in spontaneous and oxidative stress-induced mitochondrial fragmentation in TriPeptidyl Peptidase-1 (TPP-1) deficient fibroblasts. Bioscience reports 2012.


Hypersensitivity of mtDNA-depleted cells to staurosporine-induced apoptosis: roles of Bcl-2 downregulation and cathepsin B. Rommelaere G, Michel S, Mercy L, Fattaccioli A, Demazy C, Ninane N, Houbion A, Renard P, Arnould T. Am J Physiol Cell Physiol. 2011 May;300(5):C1090-106