Development, Stem cells & Differentiation



Detraux D, Caruso M, Feller L, Fransolet M, Meurant S, Mathieu J, Arnould T, Renard P. A critical role for heme synthesis and succinate in the regulation of pluripotent states transitions. Elife. 2023 Jul 10;12:e78546.

Amato I, Meurant S, Renard P. The Key Role of Mitochondria in Somatic Stem Cell Differentiation: From Mitochondrial Asymmetric Apportioning to Cell Fate. Int J Mol Sci. 2023 Jul 29;24(15):12181.

Ems G, Severino L, Nisolle JF, Nicaise C, Lambrichts I, LoMonaco M, Bronckaers A, Hontoir F, Vandeweerd JM. Volumetry of ovine incisors dental pulp for further regenerative therapy. Anat Histol Embryol. 2023 Jun 5.

Dechêne L, Colin M, Demazy C, Fransolet M, Niesten A, Arnould T, Serteyn D, Dieu M, Renard P. Characterization of the Proteins Secreted by Equine Muscle-Derived Mesenchymal Stem Cells Exposed to Cartilage Explants in Osteoarthritis Model. Stem Cell Rev Rep. 2023 Feb;19(2):550-567.


Neumann M, Arnould T, Su BL. Encapsulation of stem-cell derived β-cells: A promising approach for the treatment for type 1 diabetes mellitus. J Colloid Interface Sci. 2022 Dec 24;636:90-102.

Caruso M, Meurant S, Detraux D, Mathieu A, Gilson M, Dieu M, Fattaccioli A, Demazy C, Najimi M, Sokal E, Arnould T, Verfaillie C, Lafontaine DLJ, Renard P. The global downregulation of protein synthesis observed during hepatogenic maturation is associated with a decrease in TOP mRNA translation. Stem Cell Reports. 2023 Jan 10;18(1):254-268.

Detraux D, Renard P. Succinate as a New Actor in Pluripotency and Early Development? Metabolites. 2022 Jul 15;12(7):651.

Finet O, Yague-Sanz C, Marchand F, Hermand D. The Dihydrouridine landscape from tRNA to mRNA: a perspective on synthesis, structural impact and function. RNA Biol. 2022 Jan;19(1):735-750.

Finet O, Yague-Sanz C, Hermand D. Epitranscriptomic mapping of RNA modifications at single-nucleotide resolution using rhodamine sequencing (Rho-seq). STAR Protoc. 2022 May 5;3(2):101369.


Finet O, Yague-Sanz C, Krüger LK, Tran P, Migeot V, Louski M, Nevers A, Rougemaille M, Sun J, Ernst FGM, Wacheul L, Wery M, Morillon A, Dedon P, Lafontaine DLJ, Hermand D. Transcription-wide mapping of dihydrouridine reveals that mRNA dihydrouridylation is required for meiotic chromosome segregation. Mol Cell. 2021 Nov 15:S1097-2765(21)00953-9.

Merckx G, Lo Monaco M, Lambrichts I, Himmelreich U, Bronckaers A, Wolfs E. Safety and Homing of Human Dental Pulp Stromal Cells in Head and Neck Cancer. Stem Cell Rev Rep. 2021 Oct;17(5):1619-1634.

Colin M, Dechêne L, Ceusters J, Niesten A, Demazy C, Lagneaux L, Zouaoui Boudjeltia K, Franck T, Van Antwerpen P, Renard P, Mathieu V, Serteyn D. Priming of mesenchymal stem cells with a hydrosoluble form of curcumin allows keeping their mesenchymal properties for cell-based therapy development. J Cell Mol Med. 2021 Mar 26.

Belmans N, Gilles L, Welkenhuysen J, Vermeesen R, Baselet B, Salmon B, Baatout S, Jacobs R, Lucas S, Lambrichts I, Moreels M. In vitro Assessment of the DNA Damage Response in Dental Mesenchymal Stromal Cells Following Low Dose X-ray Exposure. Front Public Health. 2021 Feb 15;9:584484.

Shayegan A, Zucchi A, De Swert K, Balau B, Truyens C, Nicaise C. Lipoteichoic acid stimulates the proliferation, migration and cytokine production of adult dental pulp stem cells without affecting osteogenic differentiation. Int Endod J. 2021 Apr;54(4):585-600.


Merckx G, Tay H, Lo Monaco M, van Zandvoort M, De Spiegelaere W, Lambrichts I, Bronckaers A. Chorioallantoic Membrane Assay as Model for Angiogenesis in Tissue Engineering: Focus on Stem Cells. Tissue Eng Part B Rev. 2020 Dec;26(6):519-539.

Cassart C, Yague-Sanz C, Bauer F, Ponsard P, Stubbe FX, Migeot V, Wery M, Morillon A, Palladino F, Robert V, Hermand D. RNA polymerase II CTD S2P is dispensable for embryogenesis but mediates exit from developmental diapause in C. elegans. Sci Adv. 2020 Dec 9;6(50):eabc1450.

Luyten LJ, Dieu M, Demazy C, Fransolet M, Nawrot TS, Renard P, Debacq-Chainiaux F. Optimization of label-free nano LC-MS/MS analysis of the placental proteome. Placenta. 2020 Nov;101:159-162.

Luyten LJ, Dockx Y, Madhloum N, Sleurs H, Gerrits N, Janssen BG, Neven KY, Plusquin M, Provost EB, De Boever P, Nawrot TS. Association of Retinal Microvascular Characteristics With Short-term Memory Performance in Children Aged 4 to 5 Years. JAMA Netw Open. 2020 Jul 1;3(7):e2011537.

Lo Monaco M, Gervois P, Beaumont J, Clegg P, Bronckaers A, Vandeweerd JM, Lambrichts I. Therapeutic Potential of Dental Pulp Stem Cells and Leukocyte- and Platelet-Rich Fibrin for Osteoarthritis. Cells. 2020 Apr 15;9(4).

Madhloum N, Luyten LJ, Provost EB, De Boever P, Dockx Y, Sleurs H, Plusquin M, Roodt JO, Vrijens K, Nawrot TS. Establishing reference values for macro- and microvascular measurements in 4-to-5 year-old children of the ENVIRONAGE prospective birth cohort. Sci Rep. 2020 Mar 20;10(1):5107.

Luyten LJ, Dockx Y, Provost EB, Madhloum N, Sleurs H, Neven KY, Janssen BG, Bové H, Debacq-Chainiaux F, Gerrits N, Lefebvre W, Plusquin M, Vanpoucke C, De Boever P, Nawrot TS. Children's microvascular traits and ambient air pollution exposure during pregnancy and early childhood: prospective evidence to elucidate the developmental origin of particle-induced disease. BMC Med. 2020 May 26;18(1):128.

Cox B, Luyten LJ, Dockx Y, Provost E, Madhloum N, De Boever P, Neven KY, Sassi F, Sleurs H, Vrijens K, Vineis P, Plusquin M, Nawrot TS. Association Between Maternal Prepregnancy Body Mass Index and Anthropometric Parameters, Blood Pressure, and Retinal Microvasculature in Children Age 4 to 6 Years. JAMA Netw Open. 2020 May 1;3(5):e204662.

Gilloteaux J. Primary cilia in the Syrian hamster biliary tract: Bile flow antennae and outlooks about signaling on the hepato-biliary-pancreatic stem cells. Translational Research in Anatomy. 2020 Volume 19, 100063.

Hussain A, Gilloteaux J. The human testes: Estrogen and ageing outlooks. Translational Research in Anatomy. 2020 Volume 20, 100073.


Storder J, Renard P, Arnould T. Update on the role of Sirtuin 3 in cell differentiation: a major metabolic target that can be pharmacologically controlled. Biochem Pharmacol. 2019 Nov;169:113621.

Stevens S, Agten A, Wisanto E, Monaco ML, Verbrugghe J, Timmermans A, Lambrichts I, Vandenabeele F. Chondroid metaplasia of paraspinal connective tissue in the degenerative spine. Anat Cell Biol. 2019 Jun;52(2):204-207.

Candiracci J, Migeot V, Chionh YH, Bauer F, Brochier T, Russell B, Shiozaki K, Dedon P, Hermand D. Reciprocal regulation of TORC signaling and tRNA modifications by Elongator enforces nutrient-dependent cell fate. Sci Adv. 2019 Jun 19;5(6):eaav0184.

Mitchell R, Mellows B, Sheard J, Antonioli M, Kretz O, Chambers D, Zeuner MT, Tomkins JE, Denecke B, Musante L, Joch B, Debacq-Chainiaux F, Holthofer H, Ray S, Huber TB, Dengjel J, De Coppi P, Widera D, Patel K. Secretome of adipose-derived mesenchymal stem cells promotes skeletal muscle regeneration through synergistic action of extracellular vesicle cargo and soluble proteins. Stem Cell Res Ther. 2019 Apr 5;10(1):116.


Vatzaki E, Straus S, Dogne JM, Garcia Burgos J, Girard T, Martelletti P. Latest clinical recommendations on valproate use for migraine prophylaxis in women of childbearing age: overview from European Medicines Agency and European Headache Federation. J Headache Pain. 2018 Aug 14;19(1):68.

Luyten LJ, Saenen ND, Janssen BG, Vrijens K, Plusquin M, Roels HA, Debacq-Chainiaux F, Nawrot TS. Air pollution and the fetal origin of disease: A systematic review of the molecular signatures of air pollution exposure in human placenta. Environ Res. 2018 Jun 13;166:310-323.

Lo Monaco M, Merckx G, Ratajczak J, Gervois P, Hilkens P, Clegg P, Bronckaers A, Vandeweerd J-M, and Lambrichts I. Stem Cells for Cartilage Repair: Preclinical Studies and Insights in Translational Animal Models and Outcome Measures. Stem Cells Int. 2018 Feb 5;2018:9079538.

Fauquenoy S, Migeot V, Finet O, Yague-Sanz C, Khorosjutina O, Ekwall K, Hermand D. Repression of Cell Differentiation by a cis-Acting lincRNA in Fission Yeast. Curr Biol. 2018 Feb 5;28(3):383-391.e3.

Yague-Sanz C, Hermand D. SL-quant: a fast and flexible pipeline to quantify spliced leader trans-splicing events from RNA-seq data. Gigascience. 2018 Jul 1;7(7).

Wery M, Gautier C, Descrimes M, Yoda M, Migeot V, Hermand D, Morillon A. Bases of antisense lncRNA-associated regulation of gene expression in fission yeast. PLoS Genet. 2018 Jul 5;14(7):e1007465.

Wery M, Gautier C, Descrimes M, Yoda M, Vennin-Rendos H, Migeot V, Gautheret D, Hermand D, Morillon A. Native elongating transcript sequencing reveals global anti-correlation between sense and antisense nascent transcription in fission yeast. RNA. 2018 Feb;24(2):196-208.

Migeot V, Hermand D. Chromatin Immunoprecipitation-Polymerase Chain Reaction (ChIP-PCR) Detects Methylation, Acetylation, and Ubiquitylation in S. pombe. Methods Mol Biol. 2018;1721:25-34.


Kajitani T, Kato H, Chikashige Y, Tsutsumi C, Hiraoka Y, Kimura H, Ohkawa Y, Obuse C, Hermand D, Murakami Y. Ser7 of RNAPII-CTD facilitates heterochromatin formation by linking ncRNA to RNAi. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11208-E11217.

Mellows B, Mitchell R, Antonioli M, Kretz O, Chambers D, Zeuner MT, Denecke B, Musante L, Ramachandra DL, Debacq-Chainiaux F, Holthofer H, Joch B, Ray S, Widera D, David AL, Huber TB, Dengjel J, De Coppi P, Patel K. Protein and Molecular Characterization of a Clinically Compliant Amniotic Fluid Stem Cell-Derived Extracellular Vesicle Fraction Capable of Accelerating Muscle Regeneration Through Enhancement of Angiogenesis. Stem Cells Dev. 2017 Sep 15;26(18):1316-1333.

Wanet A, Caruso M, Domelevo Entfellner JB, Najar M, Fattaccioli A, Demazy C,Evraerts J, El-Kehdy H, Pourcher G, Sokal E, Arnould T, Tiffin N, Najimi M, Renard P. The Transcription Factor 7-Like 2-Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Axis Connects Mitochondrial Biogenesis and Metabolic Shift with Stem Cell Commitment to Hepatic Differentiation. Stem Cells. 2017 Oct;35(10):2184-2197.

Yague-Sanz C, Vázquez E, Sánchez M, Antequera F, Hermand D. A conserved role of the RSC chromatin remodeler in the establishment of nucleosome-depleted regions. Curr Genet. 2017 May;63(2):187-193.


Puissant E, Boonen M. Monocytes/Macrophages Upregulate the Hyaluronidase HYAL1 and Adapt Its Subcellular Trafficking to Promote Extracellular Residency upon Differentiation into Osteoclasts. PLoS One. 2016 Oct 18;11(10):e0165004.

Boonen M, Staudt C, Gilis F, Oorschot V, Klumperman J, Jadot M. Cathepsin D and its newly identified transport receptor SEZ6L2 can modulate neurite outgrowth. J Cell Sci. 2016 Feb 1;129(3):557-68.

Materne P, Vázquez E, Sánchez M, Yague-Sanz C, Anandhakumar J, Migeot V, Antequera F, Hermand D. Histone H2B ubiquitylation represses gametogenesis by opposing RSC-dependent chromatin remodeling at the ste11 master regulator locus. Elife. 2016 May 12;5.


Wanet A, Arnould T, Najimi M, Renard P. Connecting Mitochondria, Metabolism, and Stem Cell Fate. Stem Cells Dev. 2015 Sep 1;24(17):1957-71.


Wanet A, Remacle N, Najar M, Sokal E, Arnould T, Najimi M, Renard P Mitochondrial remodeling in hepatic differentiation and dedifferentiation. The international journal of biochemistry & cell biology 2014, 54:174-185.


Dombret C, Nguyen T, Schakman O, Michaud JL, Hardin-Pouzet H, Bertrand MJ, De Backer O. Loss of Maged1 results in obesity, deficits of social interactions, impaired sexual behavior and severe alteration of mature oxytocin production in the hypothalamus. Hum Mol Genet. 2012 Nov 1;21(21):4703-17.

Calabrese G, Bennett BJ, Orozco L, Kang HM, Eskin E, Dombret C, De Backer O, Lusis AJ, Farber CR. Systems genetic analysis of osteoblast-lineage cells. PLoS Genet. 2012;8(12):e1003150.

Wanet A, Tacheny A, Arnould T, Renard P miR-212/132 expression and functions: within and beyond the neuronal compartment. Nucleic acids research 2012, 40:4742-4753.a


Nguyen TH, Bertrand MJ, Sterpin C, Achouri Y, De Backer OR. Maged1, a new regulator of skeletal myogenic differentiation and muscle regeneration. BMC Cell Biol. 2010 Jul 20;11:57.