Ageing

Publications

2024

Calluy E, Beaudart C, Alokail MS, Al-Daghri NM, Bruyère O, Reginster JY, Cavalier E, Ladang A. Confounding factors of the expression of mTBI biomarkers, S100B, GFAP and UCH-L1 in an aging population. Clin Chem Lab Med. 2024 Apr 22.

Fuggle NR, Beaudart C, Bruyère O, Abrahamsen B, Al-Daghri N, Burlet N, Chandran M, Rosa MM, Cortet B, Demonceau C, Dere W, Halbout P, Hiligsmann M, Kanis JA, Kaufman JM, Kurth A, Lamy O, Laslop A, Maggi S, Matijevic R, McCloskey E, Mobasheri A, Prieto Yerro MC, Radermecker RP, Sabico S, Al-Saleh Y, Silverman S, Veronese N, Rizzoli R, Cooper C, Reginster JY, Harvey NC. Evidence-Based Guideline for the management of osteoporosis in men. Nat Rev Rheumatol. 2024 Mar 14.

Millet M, Auroux M, Beaudart C, Demonceau C, Ladang A, Cavalier E, Reginster JY, Bruyère O, Chapurlat R, Rousseau JC. Association of circulating hsa-miRNAs with sarcopenia: the SarcoPhAge study. Aging Clin Exp Res. 2024 Mar 14;36(1):70.

Sanchez-Rodriguez D, Bruyère O, Surquin M, Reginster JY, Beaudart C. Towards a core outcome set (COS) for intrinsic capacity (IC) intervention studies in adults in midlife and beyond: a scoping review to identify frequently used outcomes and measurement tools. Aging Clin Exp Res. 2024 Mar 5;36(1):54.

Beaudart C, Sharma M, Clark P, Fujiwara S, Adachi JD, Messina OD, Morin SN, Kohlmeier LA, Sangan CB, Nogues X, Cruz-Priego GA, Cavallo A, Cooper F, Grier J, Leckie C, Montiel-Ojeda D, Papaioannou A, Raskin N, Yurquina L, Wall M, Bruyère O, Boonen A, Dennison E, Harvey NC, Kanis JA, Kaux JF, Lewiecki EM, Lopez-Borbon O, Paskins Z, Reginster JY, Silverman S, Hiligsmann M. Patients' preferences for fracture risk communication: the Risk Communication in Osteoporosis (RICO) study. Osteoporos Int. 2024 Mar;35(3):451-468.

Beaudart C. The influence of physical activity on sarcopenia. Lancet Healthy Longev. 2024 Feb;5(2):e86-e87.

Kochlik B, Herpich C, Moreno-Villanueva M, Klaus S, Müller-Werdan U, Weinberger B, Fiegl S, Toussaint O, Debacq-Chainiaux F, Schön C, Bernhard J, Breusing N, Gonos ES, Franceschi C, Capri M, Sikora E, Hervonen A, Hurme M, Slagboom PE, Dollé MET, Jansen E, Grune T, Bürkle A, Norman K. Associations of circulating GDF15 with combined cognitive frailty and depression in older adults of the MARK-AGE study. Geroscience. 2024 Apr;46(2):1657-1669.

Beaudart C, Tilquin N, Abramowicz P, Baptista F, Peng DJ, de Souza Orlandi F, Drey M, Dzhus M, Fábrega-Cuadros R, Fernandez-Garrido J, Laurindo LF, Gasparik AI, Geerinck A, Emin G, Iacob S, Kilaitė J, Kumar P, Lee SC, Lou VWQ, Mahmoodi M, Matijevic R, Matveeva MV, Merle B, Montero-Errasquín B, Bhattoa HP, Safonova Y, Şimşek H, Topinkova E, Tsekoura M, Erdoğan T, Yoo JI, Yu R, Hiligsmann M, Reginster JY, Bruyère O. Quality of life in sarcopenia measured with the SarQoL questionnaire: A meta-analysis of individual patient data. Maturitas. 2024 Feb;180:107902.

2023

Beaudart C, Li N, Boonen A, Hiligsmann M. Burden of osteoarthritis in the Netherlands: a scoping review. Expert Rev Pharmacoecon Outcomes Res. 2023 Jul-Dec;23(10):1147-1167.

Giroud J, Bouriez I, Paulus H, Pourtier A, Debacq-Chainiaux F, Pluquet O. Exploring the Communication of the SASP: Dynamic, Interactive, and Adaptive Effects on the Microenvironment. Int J Mol Sci. 2023 Jun 28;24(13):10788.

Giacconi R, Piacenza F, Aversano V, Zampieri M, Bürkle A, Villanueva MM, Dollé MET, Jansen E, Grune T, Gonos ES, Franceschi C, Capri M, Weinberger B, Sikora E, Toussaint O, Debacq-Chainiaux F, Stuetz W, Slagboom PE, Bernhardt J, Fernández-Sánchez ML, Provinciali M, Malavolta M. Uncovering the Relationship between Selenium Status, Age, Health, and Dietary Habits: Insights from a Large Population Study including Nonagenarian Offspring from the MARK-AGE Project. Nutrients. 2023 May 4;15(9):2182.

Hebishy M, Shintouo CM, Dufait I, Debacq-Chainiaux F, Bautmans I, Njemini R. Heat shock proteins and cellular senescence in humans: A systematic review. Arch Gerontol Geriatr. 2023 May 11;113:105057.

Bauwens E, Parée T, Meurant S, Bouriez I, Hannart C, Wéra AC, Khelfi A, Fattaccioli A, Burteau S, Demazy C, Fransolet M, De Schutter C, Martin N, Théry J, Decanter G, Penel N, Bury M, Pluquet O, Garmyn M, Debacq-Chainiaux F. Senescence induced by UVB in keratinocytes impairs amino acids balance. J Invest Dermatol. 2023 Apr;143(4):554-565.e9.

Giacconi R, D'Aquila P, Malavolta M, Piacenza F, Bürkle A, Villanueva MM, Dollé MET, Jansen E, Grune T, Gonos ES, Franceschi C, Capri M, Gradinaru D, Grubeck-Loebenstein B, Sikora E, Stuetz W, Weber D, Toussaint O, Debacq-Chainiaux F, Hervonen A, Hurme M, Slagboom PE, Schön C, Bernhardt J, Breusing N, Duncan T, Passarino G, Bellizzi D, Provinciali M. Bacterial DNAemia in Older Participants and Nonagenarian Offspring and Association With Redox Biomarkers: Results From MARK-AGE Study. J Gerontol A Biol Sci Med Sci. 2023 Jan 26;78(1):42-50.

Kananen L, Hurme M, Bürkle A, Moreno-Villanueva M, Bernhardt J, Debacq-Chainiaux F, Grubeck-Loebenstein B, Malavolta M, Basso A, Piacenza F, Collino S, Gonos ES, Sikora E, Gradinaru D, Jansen EHJM, Dollé MET, Salmon M, Stuetz W, Weber D, Grune T, Breusing N, Simm A, Capri M, Franceschi C, Slagboom E, Talbot D, Libert C, Raitanen J, Koskinen S, Härkänen T, Stenholm S, Ala-Korpela M, Lehtimäki T, Raitakari OT, Ukkola O, Kähönen M, Jylhä M, Jylhävä J. Circulating cell-free DNA in health and disease - the relationship to health behaviours, ageing phenotypes and metabolomics. Geroscience. 2023 Feb;45(1):85-103.

Giacconi R, Laffon B, Costa S, Teixeira-Gomes A, Maggi F, Macera L, Spezia PG, Piacenza F, Bürkle A, Moreno-Villanueva M, Bonassi S, Valdiglesias V, Teixeira JP, Dollé MET, Rietman ML, Jansen E, Grune T, Gonos ES, Franceschi C, Capri M, Weinberger B, Sikora E, Stuetz W, Toussaint O, Debacq-Chainiaux F, Hervonen A, Hurme M, Slagboom PE, Schön C, Bernhardt J, Breusing N, Pásaro E, Maseda A, Lorenzo-López L, Millán-Calenti JC, Provinciali M, Malavolta M. Association of Torquetenovirus viremia with physical frailty and cognitive impairment in three independent European cohorts. Gerontology. 2023;69(6):684-693.

2022

Liberman K, Njemini R, Forti LN, Cools W, Debacq-Chainiaux F, Kooijman R, Beyer I, Bautmans I. Three Months of Strength Training Changes the Gene Expression of Inflammation-Related Genes in PBMC of Older Women: A Randomized Controlled Trial. Cells. 2022 Feb 3;11(3):531.

Sibille FX, Spinewine A, Zerah L, Maljean L, Schoevaerdts D, de Saint-Hubert M. Current practice in benzodiazepine receptor agonists deprescribing on acute geriatric wards: a cohort study. BMC Geriatr. 2022 Feb 1;22(1):88.

Stokes CS, Weber D, Wagenpfeil S, Stuetz W, Moreno-Villanueva M, Dollé MET, Jansen E, Gonos ES, Bernhardt J, Grubeck-Loebenstein B, Fiegl S, Sikora E, Toussaint O, Debacq-Chainiaux F, Capri M, Hervonen A, Slagboom PE, Breusing N, Frank J, Bürkle A, Franceschi C, Grune T. Association between fat-soluble vitamins and self-reported health status: a cross-sectional analysis of the MARK-AGE cohort. Br J Nutr. 2022 Aug 14;128(3):433-443.

2021

Pinchuk I, Kohen R, Stuetz W, Weber D, Franceschi C, Capri M, Hurme M, Grubeck-Loebenstein B, Schön C, Bernhardt J, Debacq-Chainiaux F, Dollé MET, Jansen EHJM, Gonos ES, Sikora E, Breusing N, Gradinaru D, Moreno-Villanueva M, Bürkle A, Grune T, Lichtenberg D. Do low molecular weight antioxidants contribute to the Protection against oxidative damage? The interrelation between oxidative stress and low molecular weight antioxidants based on data from the MARK-AGE study. Arch Biochem Biophys. 2021 Oct 15:109061.

D'Aquila P, Giacconi R, Malavolta M, Piacenza F, Bürkle A, Villanueva MM, Dollé MET, Jansen E, Grune T, Gonos ES, Franceschi C, Capri M, Grubeck-Loebenstein B, Sikora E, Toussaint O, Debacq-Chainiaux F, Hervonen A, Hurme M, Slagboom PE, Schön C, Bernhardt J, Breusing N, Passarino G, Provinciali M, Bellizzi D. Microbiome in Blood Samples From the General Population Recruited in the MARK-AGE Project: A Pilot Study. Front Microbiol. 2021 Jul 26;12:707515.

Warnon C, Bouhjar K, Ninane N, Verhoyen M, Fattaccioli A, Fransolet M, Lambert de Rouvroit C, Poumay Y, Piel G, Mottet D, Debacq-Chainiaux F. HDAC2 and 7 down-regulation induces senescence in dermal fibroblasts. Aging (Albany NY). 2021 Jul 12;13.

Piacenza F, Giacconi R, Costarelli L, Basso A, Bürkle A, Moreno-Villanueva M, Dollé MET, Jansen E, Grune T, Weber D, Stuetz W, Gonos ES, Schön C, Bernhardt J, Grubeck-Loebenstein B, Sikora E, Toussaint O, Debacq-Chainiaux F, Franceschi C, Capri M, Hervonen A, Hurme M, Slagboom E, Breusing N, Mocchegiani E, Malavolta M. Age, sex and BMI influence on copper, zinc and their major serum carrier proteins in a large European population including Nonagenarian Offspring from MARK-AGE study. J Gerontol A Biol Sci Med Sci. 2021 Nov 15;76(12):2097-2106.

Bacalini MG, Reale A, Malavolta M, Ciccarone F, Moreno-Villanueva M, Dollé MET, Jansen E, Grune T, Gonos ES, Schön C, Bernhardt J, Grubeck-Loebenstein B, Sikora E, Toussaint O, Debacq-Chainiaux F, Capri M, Hervonen A, Hurme M, Slagboom PE, Breusing N, Aversano V, Tagliatesta S, Franceschi C, Blasco MA, Bürkle A, Caiafa P, Zampieri M. Ageing affects subtelomeric DNA methylation in blood cells from a large European population enrolled in the MARK-AGE study. Geroscience. 2021 Jun;43(3):1283-1302.

Comans AL, Sennesael AL, Bihin B, Regnier M, Mullier F, de Saint-Hubert M. Inappropriate low dosing of direct oral anticoagulants in older patients with non-valvular atrial fibrillation: Impact on plasma drug levels. Thromb Res. 2021 May;201:139-142.

2020

Weber D, Kochlik B, Stuetz W, Dollé MET, Jansen EHJM, Grubeck-Loebenstein B, Debacq-Chainiaux F, Bernhardt J, Gonos ES, Capri M, Franceschi C, Sikora E, Moreno-Villanueva M, Bürkle A, Grune T. Medication Intake Is Associated with Lower Plasma Carotenoids and Higher Fat-Soluble Vitamins in the Cross-Sectional MARK-AGE Study in Older Individuals. J Clin Med. 2020 Jul 1;9(7):E2072.

Giacconi R, Maggi F, Macera L, Spezia PG, Pistello M, Provinciali M, Piacenza F, Basso A, Bürkle A, Moreno-Villanueva M, Dollé MET, Jansen E, Grune T, Stuetz W, Gonos ES, Schön C, Bernhardt J, Grubeck-Loebenstein B, Sikora E, Dudkowska M, Janiszewska D, Toussaint O, Chainiaux FD, Franceschi C, Capri M, Hervonen A, Hurme M, Slagboom E, Breusing N. Prevalence and loads of torquetenovirus (TTV) in the European MARK-AGE Study population. J Gerontol A Biol Sci Med Sci. 2020 Sep 25;75(10):1838-1845.

2019

Pinchuk I, Weber D, Kochlik B, Stuetz W, Toussaint O, Debacq-Chainiaux F, Dollé MET, Jansen EHJM, Gonos ES, Sikora E, Breusing N, Gradinaru D, Sindlinger T, Moreno-Villanueva M, Bürkle A, Grune T, Lichtenberg D. Gender- and age-dependencies of oxidative stress, as detected based on the steady state concentrations of different biomarkers in the MARK-AGE study. Redox Biol. 2019 Apr 15;24:101204.

Deschênes-Simard X, Parisotto M, Rowell MC, Le Calvé B, Igelmann S, Moineau-Vallée K, Saint-Germain E, Kalegari P, Bourdeau V, Kottakis F, Bardeesy N, Ferbeyre G. Circumventing senescence is associated with stem cell properties and metformin sensitivity. Aging Cell. 2019 Apr;18(2):e12889.

2018

Potier F, Degryse JM, Bihin B, Debacq-Chainiaux F, Charlet-Renard C, Martens H, de Saint-Hubert M. Health and frailty among older spousal caregivers: an observational cohort study in Belgium. BMC Geriatr. 2018 Nov 26;18(1):291.

Potier F, Degryse JM, Aubouy G, Henrard S, Bihin B, Debacq-Chainiaux F, Martens H, de Saint-Hubert M. Spousal Caregiving Is Associated with an Increased Risk of Frailty: A Case-Control Study. J Frailty Aging. 2018;7(3):170-175.

Giacconi R, Costarelli L, Piacenza F, Basso A, Bürkle A, Moreno-Villanueva M, Grune T, Weber D, Stuetz W, Gonos ES, Schön C, Grubeck-Loebenstein B, Sikora E, Toussaint O, Debacq-Chainiaux F, Franceschi C, Hervonen A, Slagboom E, Ciccarone F, Zampieri M, Caiafa P, Jansen E, Dollé MET, Breusing N, Mocchegiani E, Malavolta M. Zinc-Induced Metallothionein in Centenarian Offspring From a Large European Population: The MARK-AGE Project. J Gerontol A Biol Sci Med Sci. 2018 May 9;73(6):745-753.

Rietman ML, Spijkerman AMW, Wong A, van Steeg H, Bürkle A, Moreno-Villanueva M, Sindlinger T, Franceschi C, Grubeck-Loebenstein B, Bernhardt J, Slagboom PE, Toussaint O, Debacq-Chainiaux F, Sikora E, Gonos ES, Breusing N, Stuetz W, Weber D, Grune T, Basso A, Piacenza F, Malavolta M, Collino S, Jansen EHJM, Verschuren WMM, Dollé MET. Antioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE Study. Mech Ageing Dev. 2018 Apr 29.

Toutfaire M, Dumortier E, Fattaccioli A, Van Steenbrugge M, Proby CM, Debacq-Chainiaux F. Unraveling the interplay between senescent dermal fibroblasts and cutaneous squamous cell carcinoma cell lines at different stages of tumorigenesis. Int J Biochem Cell Biol. 2018 Mar 14;98:113-126.

Debacq-Chainiaux F, Gonos ES. Stress and Senescence: A Special Issue dedicated to Olivier Toussaint. Mech Ageing Dev. 2018 Mar;170:1.

Boilan E, Winant V, Dumortier E, ElMoualij B, Quatresooz P, Osiewacz HD, Debacq-Chainiaux F, Toussaint O. Role of Prion protein in premature senescence of human fibroblasts. Mech Ageing Dev. 2018 Mar;170:106-113.

Weinberger B, Keller M, Putzer C, Breitenberger D, Koller B, Fiegl S, Moreno-Villanueva M, Bernhardt J, Franceschi C, Voutetakis K, Gonos ES, Hurme M, Sikora E, Toussaint O, Debacq-Chainiaux F, Grune T, Breusing N, Bürkle A, Grubeck-Loebenstein B. Protection against Tetanus and Diphtheria in Europe: The impact of age, gender and country of origin based on data from the MARK-AGE Study. Exp Gerontol. 2018 May;105:109-112.

2017

Weber D, Stuetz W, Toussaint O, Debacq-Chainiaux F, Dollé MET, Jansen E, Gonos ES, Franceschi C, Sikora E, Hervonen A, Breusing N, Sindlinger T, Moreno-Villanueva M, Bürkle A, Grune T. Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project. Oxid Med Cell Longev. 2017;2017:1401452.

Toutfaire M, Bauwens E, Debacq-Chainiaux F. The impac t of cellular senescence in skin ageing: A notion of mosaic and therapeutic strategies. Biochem Pharmacol. 2017 Apr 10.

Mound A, Lozanova V, Warnon C, Hermant M, Robic J, Guere C, Vie K, Lambert de Rouvroit C, Tyteca D, Debacq-Chainiaux F, Poumay Y. Non-senescent keratinocytes organize in plasma membrane submicrometric lipid domains enriched in sphingomyelin and involved in re-epithelialization. Biochim Biophys Acta. 2017 Sep;1862(9):958-971.

2016

Ciccarone F, Malavolta M, Calabrese R, Guastafierro T, Bacalini MG, Reale A, Franceschi C, Capri M, Hervonen A, Hurme M, Grubeck-Loebenstein B, Koller B, Bernhardt J, Schӧn C, Slagboom PE, Toussaint O, Sikora E, Gonos ES, Breusing N, Grune T, Jansen E, Dollé M, Moreno-Villanueva M, Sindlinger T, Bürkle A, Zampieri M, Caiafa P. Age-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE study. Aging Cell. 2016 Aug;15(4):755-65.

2015

Bodart G, Goffinet L, Morrhaye G, Farhat K, de Saint-Hubert M, Debacq-Chainiaux F, Swine C, Geenen V, Martens HJ. Somatotrope GHRH/GH/IGF-1 axis at the crossroads between immunosenescence and frailty. Ann N Y Acad Sci. 2015 Aug 18.

Griffiths HR, Augustyniak EM, Bennett SJ, Debacq-Chainiaux F, Dunston CR, Kristensen P, Melchjorsen CJ, Navarrete SA, Simm A, Toussaint O. Novel ageing-biomarker discovery using data-intensive technologies. Mech Ageing Dev. 2015 Nov;151:114-21.

Capri M, Moreno-Villanueva M, Cevenini E, Pini E, Scurti M, Borelli V, Palmas MG, Zoli M, Schön C, Siepelmeyer A, Bernhardt J, Fiegl S, Zondag G, de Craene AJ, Hervonen A, Hurme M, Sikora E, Gonos ES, Voutetakis K, Toussaint O, Debacq-Chainiaux F, Grubeck-Loebenstein B, Bürkle A, Franceschi C. MARK-AGE population: From the human model to new insights. Mech Ageing Dev. 2015 Nov;151:13-7.

2013

Boilan E, Winant V, Dumortier E, Piret JP, Bonfitto F, Osiewacz HD, Debacq-Chainiaux F, Toussaint O Role of p38MAPK and oxidative stress in copper-induced senescence. Age (Dordr) 2013, 35:2255-2271.

2012

Debacq-Chainiaux F, Leduc C, Verbeke A, Toussaint O UV, stress and aging. Dermato-endocrinology 2012, 4:236-240.

2011

de Saint-Hubert M, Jamart J, Morrhaye G, Martens HJ, Geenen V, Duy Vo TK, Toussaint O, Swine C. Serum IL-6 and IGF-1 improve clinical prediction of functional decline after hospitalization in older patients. Aging Clin Exp Res. 2011 Apr;23(2):106-11.

Thi Kim Duy Vo, Patrice Godard, Marie de Saint-Hubert, Gabriel Morrhaye, Florence Debacq-Chainiaux, Christian Swine, Vincent Geenen, Henri J. Martens, Olivier Toussaint. Differentially abundant transcripts in PBMC of hospitalized geriatric patients with hip fracture compared to healthy aged controls. Experimental Gerontology, Volume 46, Issue 4, April 2011, Pages 257-264.

Vo TKD, de Saint-Hubert M, Morrhaye G, Godard P, Geenen V, Martens HJ, Debacq-Chainiaux F, Swine C, Toussaint O. Transcriptomic biomarkers of the response of hospitalized geriatric patients admitted with heart failure. Comparison to hospitalized geriatric patients with infectious diseases or hip fracture. Mech Ageing Dev 2011; 132(3) : 131-9.

Skytthe A, Valensin S, Jeune B, Cevenini E, Balard F, Beekman M, Bezrukov V, Blanche H, Bolund L, Broczek K, Carru C, Christensen K, Christiansen L, Collerton JC, Cotichini R, de Craen AJ, Dato S, Davies K, De Benedictis G, Deiana L, Flachsbart F, Gampe J, Gilbault C, Gonos ES, Haimes E, Hervonen A, Hurme MA, Janiszewska D, Jylhä M, Kirkwood TB, Kristensen P, Laiho P, Leon A, Marchisio A, Masciulli R, Nebel A, Passarino G, Pelicci G, Peltonen L, Perola M, Poulain M, Rea IM, Remacle J, Robine JM, Schreiber S, Scurti M, Sevini F, Sikora E, Skouteri A, Slagboom PE, Spazzafumo L, Stazi MA, Toccaceli V, Toussaint O, Törnwall O, Vaupel JW, Voutetakis K, Franceschi C; GEHA consortium. Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project. Experimental Gerontology, 2011 Nov;46(11):934-45.

Schoevaerdts D, Swine C, Verroken A, Huang TD, Glupczynski Y. Asymptomatic colonization by Clostridium difficile in elderly patients admitted to a geriatric unit: a prospective cohort study. J Am Geriatr Soc 2011; 59 : 2179-81.

Schoevaerdts D, Bogaerts P, Grimmelprez A, de Saint Hubert M, Delaere B, Jamart J, Swine Ch, Glupczynski Y. Clinical profiles of patients colonized or infected with extended-spectrum beta-lactamase producing Enterobacteriaceae isolates: a 20 month retrospective study at a Belgian University Hospital. BMC Infectious Diseases 2011; 11 : 12.

2010

Vo TK, Godard P, de Saint-Hubert M, Morrhaye G, Swine C, Geenen V, Martens HJ, Debacq-Chainiaux F, Toussaint O. Transcriptomic biomarkers of the response of hospitalized geriatric patients with infectious diseases. Immun Ageing. 2010 Aug 17;7:9.

de Saint-Hubert M, Jamart J, Boland B, Swine C, Cornette P. Comparison of three tools predicting functional decline after hospitalization of older patients. J Am Geriatr Soc. 2010 May;58(5):1003-5.

De Saint-Hubert M, Schoevaerdts D, Cornette P, D'Hoore W, Boland B, Swine C. Predicting functional adverse outcomes in hospitalized older patients: a systematic review of screening tools J Nutr Health Aging. 2010 May;14(5):394-9.