Radiobiology & radiation therapy



Schoenauen L, Coos R, Colaux J, Heuskin AC. Design and optimization of a dedicated Faraday cup for UHDR proton dosimetry: Implementation in a UHDR irradiation station. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 2024 Volume 1064, 169411.

Moris VC, Bruneau L, Berthe J, Heuskin AC, Penninckx S, Ritter S, Weber U, Durante M, Danchin EGJ, Hespeels B, Doninck KV. Ionizing radiation responses appear incidental to desiccation responses in the bdelloid rotifer Adineta vaga. BMC Biol. 2024 Jan 25;22(1):11.


Schoenauen L, Stubbe FX, Van Gestel D, Penninckx S, Heuskin AC. C. elegans: A potent model for high-throughput screening experiments investigating the FLASH effect. Clin Transl Radiat Oncol. 2023 Dec 9;45:100712.

Perrot A, Hespeels B, Van Doninck K, Heuskin AC. Adineta vaga under fire: simulating the impact of radiation. Hydrobiologia (2023).

Hespeels B, Fontaneto D, Cornet V, Penninckx S, Berthe J, Bruneau L, Larrick JW, Rapport E, Bailly J, Debortoli N, Iakovenko N, Janko K, Heuskin AC, Lucas S, Hallet B, Van Doninck K. Back to the roots, desiccation and radiation resistances are ancestral characters in bdelloid rotifers. BMC Biol. 2023 Apr 7;21(1):72.

Bruyere D, Roncarati P, Lebeau A, Lerho T, Poulain F, Hendrick E, Pilard C, Reynders C, Ancion M, Luyckx M, Renard M, Jacob Y, Twizere JC, Peiffer R, Peulen O, Delvenne P, Hubert P, McBride A, Gillet N, Masson M, Herfs M. Human papillomavirus E6/E7 oncoproteins promote radiotherapy-mediated tumor suppression by globally hijacking host DNA damage repair. Theranostics. 2023 Jan 31;13(3):1130-1149.

Ternad I, Penninckx S, Lecomte V, Vangijzegem T, Conrard L, Lucas S, Heuskin AC, Michiels C, Muller RN, Stanicki D, Laurent S. Advances in the Mechanistic Understanding of Iron Oxide Nanoparticles' Radiosensitizing Properties. Nanomaterials (Basel). 2023 Jan 2;13(1):201.


Terwagne M, Nicolas E, Hespeels B, Herter L, Virgo J, Demazy C, Heuskin AC, Hallet B, Van Doninck K. DNA repair during nonreductional meiosis in the asexual rotifer Adineta vaga. Sci Adv. 2022 Dec 2;8(48):eadc8829.


Penninckx S, Hespeels F, Smeets J, Colaux JL, Lucas S, Heuskin A-C. Metallic Nanoparticles: A Useful Prompt Gamma Emitter for Range Monitoring in Proton Therapy? Radiation. 2021; 1(4):305-316.

Yadav A, Maertens L, Meese T, Van Nieuwerburgh F, Mysara M, Leys N, Cuypers A, Janssen PJ. Genetic Responses of Metabolically Active Limnospira indica Strain PCC 8005 Exposed to γ-Radiation during Its Lifecycle. Microorganisms. 2021 Jul 30;9(8):1626.

Daems N, Michiels C, Lucas S, Baatout S, Aerts A. Gold nanoparticles meet medical radionuclides. Nucl Med Biol. 2021 Sep-Oct;100-101:61-90.

Belmans N, Oenning AC, Salmon B, Baselet B, Tabury K, Lucas S, Lambrichts I, Moreels M, Jacobs R, Baatout S. Radiobiological risks following dentomaxillofacial imaging: should we be concerned? Dentomaxillofac Radiol. 2021 Sep 1;50(6):20210153.

Belmans N, Gilles L, Welkenhuysen J, Vermeesen R, Baselet B, Salmon B, Baatout S, Jacobs R, Lucas S, Lambrichts I, Moreels M. In vitro Assessment of the DNA Damage Response in Dental Mesenchymal Stromal Cells Following Low Dose X-ray Exposure. Front Public Health. 2021 Feb 15;9:584484.

Penninckx S, Pariset E, Acuna AU, Lucas S, Costes SV. Considering Cell Proliferation to Optimize Detection of Radiation-Induced 53BP1-Positive Foci in 15 Mouse Strains Ex Vivo. Radiat Res. 2021 Jan 1;195(1):47-59.


Henthorn N, Sokol O, Durante M, De Marzi L, Pouzoulet F, Miszczyk J, Olko P, Brandenburg S, van Goethem MJ, Barazzuol L, Tambas M, Langendijk J, Davídková M, Vondráĉek V, Bodenstein E, Pawelke J, Lomax A, Weber D, Dasu A, Stenerlöw B, Poulsen P, Sørensen B, Grau C, Sitarz M, Heuskin AC, Lucas S, Warmenhoven J, Merchant M, Mackay R, Kirkby K. Mapping the Future of Particle Radiobiology in Europe: The INSPIRE Project. Frontiers in Physics 2020, 8, 438.

Pariset E, Penninckx S, Kerbaul CD, Guiet E, Macha AL, Cekanaviciute E, Snijders AM, Mao JH, Paris F, Costes SV. 53BP1 Repair Kinetics for Prediction of In Vivo Radiation Susceptibility in 15 Mouse Strains. Radiat Res. 2020 Nov 10;194(5):485-499.

Hespeels B, Penninckx S, Cornet V, Bruneau L, Bopp C, Baumlé V, Redivo B, Heuskin AC, Moeller R, Fujimori A, Lucas S, Van Doninck K. Iron Ladies - How Desiccated Asexual Rotifer Adineta vaga Deal With X-Rays and Heavy Ions? Front Microbiol. 2020 Jul 31;11:1792.

Penninckx S, Heuskin AC, Michiels C, Lucas S. Gold Nanoparticles as a Potent Radiosensitizer: A Transdisciplinary Approach from Physics to Patient. Cancers (Basel). 2020 Jul 23;12(8):E2021.

Huart C, Chen JW, Le Calvé B, Michiels C, Wéra AC. Could Protons and Carbon Ions Be the Silver Bullets Against Pancreatic Cancer? Int J Mol Sci. 2020 Jul 4;21(13):E4767.

Daems N, Verlinden B, Van Hoecke K, Cardinaels T, Baatout S, Michiels C, Lucas S, Aerts A. In Vivo Pharmacokinetics, Biodistribution and Toxicity of Antibody-Conjugated Gold Nanoparticles in Healthy Mice. J Biomed Nanotechnol. 2020 Jun 1;16(6):985-996.

Schuemann J, Bagley A, Berbeco R, Bromma K, Butterworth KT, Byrne H, Chithrani DB, Cho SH, Cook JR, Favaudon V, Gholami YH, Gargioni E, Hainfeld JF, Hespeels F, Heuskin AC, Ibeh UM, Kuncic Z, Kunjachan S, Lacombe S, Lucas S, Lux F, McMahon SJ, Nevozhay D, Ngwa W, Payne JD, Penninckx S, Porcel E, Prise KM, Rabus H, Ridwan SM, Rudek B, Sanche L, Singh B, Smilowitz HM, Sokolov KV, Sridhar S, Stanishevskiy Y, Sung W, Tillement O, Virani NA, Yantasee W, Krishnan S. Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions. Phys Med Biol. 2020 May 7.

Longton E, Lawson G, Bihin B, Mathieu I, Hanin FX, Deheneffe S, Vander Borght T, Laloux M, Daisne JF. Individualized Prophylactic Neck Irradiation in Patients with cN0 Head and Neck Cancer Based on Sentinel Lymph Node(s) Identification: Definitive Results of a Prospective Phase 1-2 Study. Int J Radiat Oncol Biol Phys. 2020 Jul 15;107(4):652-661.

Belmans N, Gilles L, Vermeesen R, Virag P, Hedesiu M, Salmon B, Baatout S, Lucas S, Lambrichts I, Jacobs R, Moreels M; DIMITRA Research Group. Quantification of DNA Double Strand Breaks and Oxidation Response in Children and Adults Undergoing Dental CBCT Scan. Sci Rep. 2020 Feb 7;10(1):2113.


Özcan-Wahlbrink M, Schifflers C, Riemer AB. Enhanced Radiation Sensitivity of Human Papillomavirus-Driven Head and Neck Cancer: Focus on Immunological Aspects. Front Immunol. 2019 Dec 3;10:2831.

Ledoux B, Dupont M, Duplaquet F, Pirard L, Ocak S, Wanet M, Remouchamps V. Illustration of a fatal radiation-induced lung aneurysm: Is central lung stereotactic radiotherapy to be banned? Cancer Radiother. 2019 Oct 11.

Daems N, Penninckx S, Nelissen I, Van Hoecke K, Cardinaels T, Baatout S, Michiels C, Lucas S, Aerts A. Gold nanoparticles affect the antioxidant status in selected normal human cells. Int J Nanomedicine. 2019 Jul 8;14:4991-5015.

Wéra AC, Lobbens A, Stoyanov M, Lucas S, Michiels C. Radiation-induced synthetic lethality: combination of poly(ADP-ribose) polymerase and RAD51 inhibitors to sensitize cells to proton irradiation. Cell Cycle. 2019 Jun 25:1-14.

Dubaere E, Goffaux M, Wanet M, Bihin B, Gheldof C, Demoulin AS, Bolly A, Bustin F, Duplaquet F, Baugnee PE, Gustin M, Hers V, Maisin F, Marchand E, Ocak S, Pirard L, Vancutsem O, Van Neck E, Vandermoten G, Zaharia L, Remouchamps V. Long term outcome after 48 Gy stereotactic ablative body radiotherapy for peripheral stage I non-small cell lung cancer. BMC Cancer. 2019 Jun 28;19(1):639.

Penninckx S, Cekanaviciute E, Degorre C, Guiet E, Viger L, Lucas S, Costes SV. Dose, LET and Strain Dependence of Radiation-Induced 53BP1+ Foci in 15 Mouse Strains Ex Vivo Introducing Novel DNA Damage Metrics. Radiat Res. 2019 May 13.

Hespeels F, Heuskin AC, Tabarrant T, Scifoni E, Kraemer M, Chêne G, Strivay D, Lucas S. Backscattered electron emission after proton impact on gold nanoparticles with and without polymer shell coating. Phys Med Biol. 2019 Apr 15.

Belmans N, Gilles L, Virag P, Hedesiu M, Salmon B, Baatout S, Lucas S, Jacobs R, Lambrichts I, Moreels M. Method validation to assess in vivo cellular and subcellular changes in buccal mucosa cells and saliva following CBCT examinations. Dentomaxillofac Radiol. 2019 Sep;48(6):20180428.

Penninckx S, Heuskin AC, Michiels C, Lucas S. Thioredoxin Reductase Activity Predicts Gold Nanoparticle Radiosensitization Effect. Nanomaterials (Basel). 2019 Feb 19;9(2).

Hespeels F, Lucas S, Tabarrant T, Scifoni E, Kraemer M, Chêne G, Strivay D, Tran HN, Heuskin AC. Experimental measurements validate the use of the binary encounter approximation model to accurately compute proton induced dose and radiolysis enhancement from gold nanoparticles. Phys Med Biol. 2019 Feb 7.

Li S, Bouchy S, Penninckx S, Marega R, Fichera O, Gallez B, Feron O, Martinive P, Heuskin AC, Michiels C, Lucas S. Antibody-functionalized gold nanoparticles as tumor targeting radiosensitizers for proton therapy. Nanomedicine (Lond). 2019 Feb;14(3):317-333.


Penninckx S, Heuskin AC, Michiels C, Lucas S. The role of thioredoxin reductase in gold nanoparticle radiosensitization effects. Nanomedicine (Lond). 2018 Nov;13(22):2917-2937.

Édeline V, Remouchamps V, Isnardi V, Vander Borght T. Multimodality imaging using PET/CT ((18)F)-fluorodeoxyglucose for radiotherapy field delineation of localized Hodgkin lymphoma. Cancer Radiother. 2018 Sep;22(5):384-392.

Berriolo-Riedinger A, Becker S, Casasnovas O, Vander Borght T, Édeline V. Role of FDG PET-CT in the treatment management of Hodgkin lymphoma. Cancer Radiother. 2018 Sep;22(5):393-400.

Genard G, Wera AC, Huart C, Le Calve B, Penninckx S, Fattaccioli A, Tabarrant  T, Demazy C, Ninane N, Heuskin AC, Lucas S, Michiels C. Proton irradiation orchestrates macrophage reprogramming through NFκB signaling. Cell Death Dis. 2018 Jun 27;9(7):728.


Genard G, Lucas S, Michiels C. Reprogramming of Tumor-Associated Macrophages with Anticancer Therapies: Radiotherapy versus Chemo- and Immunotherapies. Front Immunol. 2017 Jul 14;8:828.

Heuskin AC, Gallez B, Feron O, Martinive P, Michiels C, Lucas S. Metallic nanoparticles irradiated by low energy protons for radiation therapy: are there significant physical effects to enhance the dose delivery? Med Phys. 2017 Aug;44(8):4299-4312.

Hespeels F, Heuskin AC, Scifoni E, Kraemer M, Lucas S. Backscattered electron emission after proton impact on carbon and gold films: Experiments and simulations. 2017 Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms,Volume 401, Pages 8-17.


Li S, Penninckx S, Karmani L, Heuskin AC, Watillon K, Marega R, Zola J, Corvaglia V, Genard G, Gallez B, Feron O, Martinive P, Bonifazi D, Michiels C, Lucas S. LET-dependent radiosensitization effects of gold nanoparticles for proton irradiation. Nanotechnology. 2016 Nov 11;27(45):455101.

Heuskin AC, Osseiran AI, Tang J, Costes SV. Simulating Space Radiation-Induced Breast Tumor Incidence Using Automata. Radiat Res. 2016 Jul;186(1):27-38.

Karmani L, Levêque P, Bouzin C, Bol A, Dieu M, Walrand S, Vander Borght T, Feron O, Grégoire V, Bonifazi D, Michiels C, Lucas S, Gallez B. Biodistribution of (125)I-labeled anti-endoglin antibody using SPECT/CT imaging: Impact of in vivo deiodination on tumor accumulation in mice. Nucl Med Biol. 2016 Mar 29;43(7):415-423.


Lucas S, Feron O, Gallez B, Masereel B, Michiels C, Vander Borght T. Monte Carlo Calculation of Radioimmunotherapy with (90)Y-, (177)Lu-, (131)I-, (124)I-, and (188)Re-Nanoobjects: Choice of the Best Radionuclide for Solid Tumour Treatment by Using TCP and NTCP Concepts. Comput Math Methods Med. 2015;2015:284360.

Riquier H, Abel D, Wera AC, Heuskin AC, Genard G, Lucas S, Michiels C. Effects of Alpha Particle and Proton Beam Irradiation as Putative Cross-Talk between A549 Cancer Cells and the Endothelial Cells in a Co-Culture System. Cancers (Basel). 2015 Mar 18;7(1):481-502.


Daisne JF, Installé J, Bihin B, Laloux M, Vander Borght T, Mathieu I, Lawson G. SPECT/CT lymphoscintigraphy of sentinel node(s) for superselective prophylactic irradiation of the neck in cN0 head and neck cancer patients: a prospective phase I feasibility study. Radiat Oncol. 2014 May 28;9:121.

Heuskin AC, Michiels C, Lucas S Low dose hypersensitivity following in vitro cell irradiation with charged particles: Is the mechanism the same as with X-ray radiation? International journal of radiation biology 2014, 90:81-89.

Gontard LC, Fernandez A, Dunin-Borkowski RE, Kasama T, Lozano-Perez S, Lucas S Transmission electron microscopy of unstained hybrid Au nanoparticles capped with PPAA (plasma-poly-allylamine): Structure and electron irradiation effects. Micron (Oxford, England : 1993) 2014, 67:1-9.

Vadhavkar, N., Pham, C., Georgescu, W., Deschamps, T., Heuskin, A.-C., Tang, J., Costes, S.V. Combinatorial DNA damage pairing model based on x-ray-induced foci predicts the dose and LET dependence of cell death in human breast cells (2014) Radiation Research, 182 (3), pp. 273-281.


Wera AC, Heuskin AC, Riquier H, Michiels C, Lucas S Low-LET proton irradiation of A549 non-small cell lung adenocarcinoma cells: dose response and RBE determination. Radiation research 2013, 179:273-281.

Heuskin AC, Wera AC, Riquier H, Michiels C, Lucas S Low-Dose Hypersensitivity and Bystander Effect are Not Mutually Exclusive in A549 Lung Carcinoma Cells after Irradiation with Charged Particles Radiation research 2013, 180:491-498.

Riquier H, Wera AC, Heuskin AC, Feron O, Lucas S, Michiels C Comparison of X-ray and alpha particle effects on a human cancer and endothelial cells: survival curves and gene expression profiles Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2013, 106:397-403.

Heuskin AC, Michiels C, Lucas S Toward computer simulation of high-LET in vitro survival curves Physics in medicine and biology 2013, 58:6495-6510.


Wéra AC, Borlon C, Nuttens VE, Riquier H, Feron O, Michiels C, Lucas S. Comparison of the clonogenic survival of A549 non-small cell lung adenocarcinoma cells after irradiation with low-dose-rate beta particles and high-dose-rate X-rays. Int J Radiat Biol. 2012 Mar;88(3):253-7.


A.-C. Wéra, H. Riquier, A.-C. Heuskin, C. Michiels, S. Lucas. In vitro irradiation station for broad beam radiobiological experiments. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Volume 269, Issue 24, 15 December 2011, Pages 3120–3124

A.-C. Heuskin, A.-C. Wéra, H. Riquier, C. Michiels, A. Bulgheroni, M. Jastrzab, M. Caccia, S. Lucas. On the comparison of three methods of assessing beam quality for broad beam in vitro cell irradiation. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Volume 269, Issue 24, 15 December 2011, Pages 3132–3136

V.Nuttens, E.Nahum and S. Lucas. An NTCP Analysis of Urethral Complications from Low Doserate Mono- and Bi-Radionuclide Brachytherapy. Prostate Cancer. Volume 2011 (2011), Article ID 128360, 9 pages.