Thrombosis & hemostasis



Douxfils J, Morimont L, Gaspard U, Utian WH, Foidart JM. Estetrol is not a SERM but a NEST and has a specific safety profile on coagulation. Thromb Res. 2023 Dec;232:148-150.

Mullier F, Baccini V, Lippi G, Lecompte T. Clinical studies on platelet transfusion: Time to consider methodological issues related to platelet counting. Transfusion. 2023 Nov;63(11):2198-2200.

Foidart JM, Gemzell-Danielsson K, Kubba A, Douxfils J, Creinin MD, Gaspard U. The benefits of estetrol addition to drospirenone for contraception. AJOG Glob Rep. 2023 Sep 18;3(4):100266.

Soleimani R, Khourssaji M, Cabo J, Guldenpfennig M, Baudar J, Chatelain B, Devalet B, Bareille M, Mullier F. Letter in response to Othman & Favaloro "Comparison of two ways of performing ristocetin-induced platelet agglutination (RIPA) mixing study for diagnosis of type 2B VWD". Res Pract Thromb Haemost. 2023 Aug 7;7(6):102165.

Bareille M, Lecompte T, Mullier F. Assessment of the individual determinants of two fibrinolysis assays, GFC and ECLT in platelet-depleted plasma and derived euglobulin fraction respectively. Thromb Res. 2023 Aug 13;230:33-36.

Davoine C, Traina A, Evrard J, Lanners S, Fillet M, Pochet L. Coumarins as factor XIIa inhibitors: Potency and selectivity improvements using a fragment-based strategy. Eur J Med Chem. 2023 Jul 16;259:115636.

Lasne D, Toussaint-Hacquard M, Delassasseigne C, Bauters A, Flaujac C, Savard P, Mouton C, De Maistre E, Stepanian A, Eschwège V, Delrue M, Georges JL, Gros A, Mansour A, Leroy G, Jouffroy R, Mattei M, Beurton A, Pontis A, Neuwirth M, Nedelec-Gac F, Lecompte T, Curis E, Siguret V, Gouin-Thibault I. Factors Influencing anti-Xa assays: A Multicenter Prospective Study in Critically Ill and Noncritically Ill Patients Receiving Unfractionated Heparin. Thromb Haemost. 2023 Jun 15.

Alessi MC, Coxon C, Ibrahim-Kosta M, Bacci M, Voisin S, Rivera J, Greinacher A, Raster J, Pulcinelli F, Devreese KM, Mullier F, McCormick AN, Frontroth JP, Pouplard C, Sachs UJ, Diaz I, Bermejo N, Camera M, Fontana P, Bauters A, Stepanian A, Cozzi MR, Sveshnikova AN, Faille D, Hollon W, Chitlur M, Casonato A, Lasne D, Lavenu-Bombled C, Fiore M, Hamidou B, Hurtaud-Roux MF, Saultier P, Goumidi L, Gresele P, Lordkipanidzé M. Multi-center evaluation of light transmission platelet aggregation reagents: Communication from the ISTH SSC Subcommittee on Platelet Physiology. J Thromb Haemost. 2023 Jun 16:S1538-7836(23)00492-0.

Wauthier L, Favresse J, Hardy M, Douxfils J, Le Gal G, Roy PM, van Es N, Ay C, Ten Cate H, Lecompte T, Lippi G, Mullier F. D-dimer testing: A narrative review. Adv Clin Chem. 2023;114:151-223.

Douxfils J, Morimont L, Creinin MD, Gaspard U, Foidart JM. Hormonal therapies and venous thrombosis: considerations for prevention and management-a reappraisal. Res Pract Thromb Haemost. 2023 Apr 15;7(4):100155.

Dechamps M, De Poortere J, Octave M, Ginion A, Robaux V, Pirotton L, Bodart J, Gruson D, Van Dievoet MA, Douxfils J, Haguet H, Morimont L, Derive M, Jolly L, Bertrand L, Laterre PF, Horman S, Beauloye C. Dexamethasone Modulates the Cytokine Response but Not COVID-19-Induced Coagulopathy in Critically Ill. Int J Mol Sci. 2023 Apr 14;24(8):7278.

Douxfils J, Bouvy C, Morimont L. Evaluation of Activated Protein C Resistance Using Thrombin Generation Test. Methods Mol Biol. 2023;2663:211-224.

Foulon-Pinto G, Lafuente-Lafuente C, Jourdi G, Guen JL, Tall F, Puymirat E, Delrue M, Rivière L, Ketz F, Gouin-Thibault I, Mullier F, Gaussem P, Pautas E, Lecompte T, Curis E, Siguret V. Assessment of DOAC in GEriatrics (Adage Study): Rivaroxaban/Apixaban Concentrations and Thrombin Generation Profiles in NVAF Very Elderly Patients. Thromb Haemost. 2023 Apr;123(4):402-414.

Morimont L, Creinin MD, Gaspard U, Foidart JM, Douxfils J. Hormonal therapies and venous thrombosis: Estrogen matters! Res Pract Thromb Haemost. 2023 Feb 15;7(1):100021.

Cabo J, Morimont L, Baudar J, Guldenpfennig M, Jacqmin H, Soleimani R, Lecompte T, Douxfils J, Mullier F. Variability among commercial batches of normal pooled plasma in lupus anticoagulant testing. Int J Lab Hematol. 2023 Feb;45(1):126-136.

Bareille M, Lecompte T, Mullier F, Roullet S. Are Viscoelastometric Assays of Old Generation Ready for Disposal? Comment on Volod et al. Viscoelastic Hemostatic Assays: A Primer on Legacy and New Generation Devices. J. Clin. Med. 2022, 11, 860. J Clin Med. 2023 Jan 6;12(2):477.

Douxfils J, Gaspard U, Taziaux M, Jost M, Bouvy C, Lobo RA, Utian WH, Foidart JM. Impact of estetrol (E4) on hemostasis, metabolism and bone turnover in postmenopausal women. Climacteric. 2023 Feb;26(1):55-63.


Gillot C, Favresse J, Maloteau V, Mathieux V, Dogné JM, Mullier F, Douxfils J. Resistance towards ChadOx1 nCoV-19 in an 83 Years Old Woman Experiencing Vaccine Induced Thrombosis with Thrombocytopenia Syndrome. Vaccines (Basel). 2022 Nov 30;10(12):2056.

Morimont L, Jost M, Gaspard U, Foidart JM, Dogné JM, Douxfils J. Low Thrombin Generation in Users of a Contraceptive Containing Estetrol and Drospirenone. J Clin Endocrinol Metab. 2022 Dec 17;108(1):135-143.

Hardy M, Michaux I, Bulpa P, Schonau B, Nicolay B, de Maistre E, Godon A, Lecompte T, Mullier F. Serial fibrin monomer and D-dimer plasma levels measurements can capture thrombotic complications in critically ill COVID-19 patients: A prospective observational study. Thromb Res. 2022 Dec 1;221:69-72.

Bareille M, Hardy M, Chatelain B, Lecompte T, Mullier F. Laboratory evaluation of a new integrative assay to phenotype plasma fibrinolytic system. Thromb J. 2022 Dec 5;20(1):73.

Wauthier L, Favresse J, Hardy M, Douxfils J, Le Gal G, Roy PM, van Es N, Ay C, Ten Cate H, Vander Borght T, Dupont MV, Lecompte T, Lippi G, Mullier F. D-dimer Testing in Pulmonary Embolism with a Focus on Potential Pitfalls: A Narrative Review. Diagnostics (Basel). 2022 Nov 12;12(11):2770.

Foulon-Pinto G, Lafuente C, Jourdi G, Le Guen J, Tall F, Puymirat E, Delrue M, Riviere L, Ketz F, Gouin-Thibault I, Mullier F, Gaussem P, Pautas E, Lecompte T, Curis E, Siguret V. Assessment of DOAC in GEriatrics (ADAGE study): rivaroxaban/apixaban concentrations and thrombin generation profiles in NVAF very elderly patients. Thromb Haemost. 2022 Nov 17.

Evrard J, Siriez R, Bouvy C, Favresse J, Yildiz H, Hainaut P, Mullier F, Dogné JM, Douxfils J. Comparison of analytical performances between clot waveform analysis and FibWave in edoxaban-treated patients and healthy controls. Res Pract Thromb Haemost. 2022 Nov 4;6(7):e12804.

Buoninfante A, Andeweg A, Baker AT, Borad M, Crawford N, Dogné JM, Garcia-Azorin D, Greinacher A, Helfand R, Hviid A, Kochanek S, López-Fauqued M, Nazy I, Padmanabhan A, Pavord S, Prieto-Alhambra D, Tran H, Wandel Liminga U, Cavaleri M. Understanding thrombosis with thrombocytopenia syndrome after COVID-19 vaccination. NPJ Vaccines. 2022 Nov 9;7(1):141.

Douxfils J, Morimont L, Gaspard U, Utian WH, Foidart JM. Estetrol is not a SERM but a NEST and has a specific safety profile on coagulation. Thromb Res. 2022 Sep 16:S0049-3848(22)00387-5.

Gosselin RC, Favaloro EJ, Douxfils J. The Myths Behind DOAC Measurement: Analyses of Prescribing Information from Different Regulatory Bodies and a Call for Harmonization. J Thromb Haemost. 2022 Nov;20(11):2494-2506.

Testa S, Meijer P, Lasne D, Mullier F. Implementation of the new EUR IVD regulation and relation with ISO15189 accreditation: Guidance is urgently required for haemostasis testing. Int J Lab Hematol. 2022 Sep;44 Suppl 1:71-78.

Morimont L, Donis N, Bouvy C, Mullier F, Dogné JM, Douxfils J. Laboratory Testing for the Evaluation of Phenotypic Activated Protein C Resistance. Semin Thromb Hemost. 2022 Sep;48(6):680-689.

Morimont L, Dechamps M, David C, Bouvy C, Gillot C, Haguet H, Favresse J, Ronvaux L, Candiracci J, Herzog M, Laterre PF, De Poortere J, Horman S, Beauloye C, Douxfils J. NETosis and Nucleosome Biomarkers in Septic Shock and Critical COVID-19 Patients: An Observational Study. Biomolecules. 2022 Jul 27;12(8):1038.

Gemzell-Danielsson K, Cagnacci A, Chabbert-Buffet N, Douxfils J, Foidart JM, Kubba A, Lete Lasa LI, Mansour D, Neulen J, Neves J, Palma F, Römer T, Spaczyński R, Tóth V. A novel estetrol-containing combined oral contraceptive: European expert panel review. Eur J Contracept Reprod Health Care. 2022 Oct;27(5):373-383.

Lippi G, Mullier F, Favaloro EJ. D-dimer: old dogmas, new (COVID-19) tricks. Clin Chem Lab Med. 2022 Jul 14;61(5):841-850.

Merrelaar AE, Bögl MS, Buchtele N, Merrelaar M, Herkner H, Schoergenhofer C, Harenberg J, Douxfils J, Siriez R, Jilma B, Spiel AO, Schwameis M. Performance of a Qualitative Point-of-Care Strip Test to Detect DOAC Exposure at the Emergency Department: A Cohort-Type Cross-Sectional Diagnostic Accuracy Study. Thromb Haemost. 2022 Oct;122(10):1723-1731.

Hardy M, Bareille M, Lecompte T, Mullier F. Don't let D-dimer fool you: Elevated D-dimer plasma levels should not imply 'hyperfibrinolysis'. Thromb Res. 2022 Jun;214:63-64.

Hardy M, Douxfils J, Dincq AS, Sennesael AL, Xhaet O, Mullier F, Lessire S. Uninterrupted DOACs Approach for Catheter Ablation of Atrial Fibrillation: Do DOACs Levels Matter? Front Cardiovasc Med. 2022 Mar 29;9:864899.

Morimont L, Leclercq C, Didembourg M, De Gottal É, Carlo A, Gaspard U, Dogné JM, Douxfils J. Analytical performance of the endogenous thrombin potential-based activated protein C resistance assay on the automated ST Genesia system. Res Pract Thromb Haemost. 2022 Apr 7;6(3):e12684.

Evrard J, Maloteau V, Dogné JM, Douxfils J. Simultaneous assessment of DOACs effect on clot formation and fibrinolysis with the FibWave. Int J Lab Hematol. 2022 Apr;44(2):e79-e83.

Siriez R, Yildiz H, Bouvy C, Haguet H, Maloteau V, Hardy M, Mullier F, Dogné JM, Hainaut P, Douxfils J. The edoxaban-M4 metabolite and measurement of edoxaban by chromogenic assays in human plasma. Res Pract Thromb Haemost. 2022 Apr 11;6(3):e12680.

Gerard C, Arnal JF, Jost M, Douxfils J, Lenfant F, Fontaine C, Houtman R, Archer DF, Reid RL, Lobo RA, Gaspard U, Coelingh Bennink HJT, Creinin MD, Foidart JM. Profile of estetrol, a promising native estrogen for oral contraception and the relief of climacteric symptoms of menopause. Expert Rev Clin Pharmacol. 2022 Feb;15(2):121-137.

Lardinois B, Hardy M, Michaux I, Horlait G, Rotens T, Jacqmin H, Lessire S, Bulpa P, Dive A, Mullier F. Monitoring of Unfractionated Heparin Therapy in the Intensive Care Unit Using a Point-of-Care aPTT: A Comparative, Longitudinal Observational Study with Laboratory-Based aPTT and Anti-Xa Activity Measurement. J Clin Med. 2022 Feb 28;11(5):1338.

Hardy M, Douxfils J, Morimont L, Didembourg M, Carlo A, de Maistre E, Lecompte T, Mullier F. Study of in vitro thrombin generation after neutralization of heparin. Int J Lab Hematol. 2022 Feb;44(1):168-176.

Gaudard M, Boissier E, Talon L, Douxfils J, Sapin AF, Sinegre T, Lebreton A. Stability of coagulation parameters in plasma samples at room temperature after one freeze/thaw cycle. Int J Lab Hematol. 2022 Jun;44(3):610-618.

Pouplard C, Rollin J, Vayne C, Charuel N, Ahmadi Z, Alberio L, Azjenberg N, Althaus K, Bakchoul T, Chong B, Curtis BR, Faille D, Gomez FJ, Gresele P, Morel-Kopp MC, Mullier F, Nazy I, Smith JW, Greinacher A, Gruel Y. Multicentre evaluation of 5B9, a monoclonal anti-PF4/heparin IgG mimicking human hit antibodies, as an internal quality control in hit functional assays: communication from the isth ssc subcommittee on platelet immunology. J Thromb Haemost. 2022 Jan;20(1):252-259.

Didembourg M, Douxfils J, Carlo A, Mullier F, Hardy M, Morimont L. Effect of tissue factor pathway inhibitor on thrombin generation assay. Int J Lab Hematol. 2022 Jun;44(3):e115-e119.


Morimont L, Haguet H, Dogné JM, Gaspard U, Douxfils J. Combined Oral Contraceptives and Venous Thromboembolism: Review and Perspective to Mitigate the Risk. Front Endocrinol (Lausanne). 2021 Dec 9;12:769187.

Morimont L, Didembourg M, Haguet H, Modaffari É, Tillier M, Bouvy C, Lebreton A, Dogné JM, Douxfils J. Interlaboratory variability of activated protein C resistance using the ETP-based APC resistance assay. Res Pract Thromb Haemost. 2021 Nov 2;5(7):e12612.

Davoine C, Pardo A, Pochet L, Fillet M. Fragment Hit Discovery and Binding Site Characterization by Indirect Affinity Capillary Electrophoresis: Application to Factor XIIa. Anal Chem. 2021 Oct 25.

Rodriguez EVC, Bouazza FZ, Dauby N, Mullier F, d'Otreppe S, Jissendi Tchofo P, Bartiaux M, Sirjacques C, Roman A, Hermans C, Cliquennois M. Fatal vaccine-induced immune thrombotic thrombocytopenia (VITT) post Ad26.COV2.S: first documented case outside US. Infection. 2021 Oct 9.

Martini A, Harenberg J, Bauersachs R, Beyer-Westendorf J, Crowther M, Douxfils J, Elalamy I, Weiss C, Hetjens S. Detection of Direct Oral Anticoagulants in Patient Urine Samples by Prototype and Commercial Test Strips for DOACs - A Systematic Review and Meta-analysis. TH Open. 2021 Sep 24;5(3):e438-e448.

Gillot C, Favresse J, Mullier F, Lecompte T, Dogné JM, Douxfils J. NETosis and the Immune System in COVID-19: Mechanisms and Potential Treatments. Front Pharmacol. 2021 Aug 5;12:708302.

Douxfils J, Vayne C, Pouplard C, Lecompte T, Favresse J, Potier F, Gasser E, Mathieux V, Dogné JM, Gruel Y, Rollin J, Mullier F. Fatal exacerbation of ChadOx1-nCoV-19-induced thrombotic thrombocytopenia syndrome after initial successful therapy with intravenous immunoglobulins - a rational for monitoring immunoglobulin G levels. Haematologica. 2021 Aug 12.

Hardy M, Dellanoce C, Douxfils J, Carlo A, Lessire S, Bouvy C, Testa S, Mullier F. Impact of centrifugation on thrombin generation in healthy subjects and in patients treated with direct oral anticoagulants. Int J Lab Hematol. 2021 Jul 12.

Godon A, Durand Z, Agier L, Lecompte T, Mullier F, Marlu R, de Maistre E, Tacquard C, Levy JH, Godier A, Susen S, Albaladejo P. Comparison of Fibrin Monomers and D-dimers to predict thrombotic events in critically ill patients with COVID-19 pneumonia: A retrospective study. Thromb Res. 2021 Sep;205:8-10.

Favresse J, Bayart JL, Burlacu MC, Maiter D, Dogné JM, Douxfils J, Gruson D. Usefulness of a Non-Streptavidin Bead Technology to Overcome Biotin Interference: Proof of Principle with 25-OH Vitamin D, TSH, and FT4. J Appl Lab Med. 2021 Jul 7;6(4):1072-1077.

Sennesael AL, Larock AS, Hainaut P, Lessire S, Hardy M, Douxfils J, Spinewine A, Mullier F. The impact of strong inducers on direct oral anticoagulant levels. Am J Med. 2021 Oct;134(10):1295-1299.

Douxfils J, Favresse J, Dogné JM, Lecompte T, Susen S, Cordonnier C, Lebreton A, Gosselin R, Sié P, Pernod G, Gruel Y, Nguyen P, Vayne C, Mullier F. Hypotheses behind the very rare cases of thrombosis with thrombocytopenia syndrome after SARS-CoV-2 vaccination. Thromb Res. 2021 May 15;203:163-171.

Douxfils J, Evrard J, Hardy M, Mullier F. Comparison is not reason: Pitfalls in reporting thrombin generation results in anticoagulated patients. Res Pract Thromb Haemost. 2021 May 1;5(4):e12523.

Hardy M, Michaux I, Dive A, Lecompte T, Mullier F. Could Daily Monitoring of Fibrin Related Markers Help Suspect a Thrombotic Event in COVID-19 Patients? A Prospective Pilot Study. TH Open. 2021 May 12;5(2):e152-e154.

Bareille M, Hardy M, Douxfils J, Roullet S, Lasne D, Levy JH, Stépanian A, Susen S, Frère C, Lecompte T, Mullier F. Viscoelastometric Testing to Assess Hemostasis of COVID-19: A Systematic Review. J Clin Med. 2021 Apr 16;10(8):1740.

Tardy-Poncet B, de Maistre E, Pouplard C, Presles E, Alhenc-Gelas M, Lasne D, Horellou MH, Mouton C, Serre-Sapin A, Bauters A, Nguyen P, Mullier F, Perrin J, Le Gal G, Morange PE, Grunebaum L, Lillo-Le Louet A, Elalamy I, Gruel Y, Greinacher A, Lecompte T, Tardy B; GFHT-HIT study group. Heparin-induced thrombocytopenia: construction of a pre-test diagnostic score derived from the analysis of a prospective multinational database, with internal validation. J Thromb Haemost. 2021 Aug;19(8):1959-1972.

Douxfils J, Adcock D, Bates SM, Favaloro EJ, Gouin-Thibault I, Guillermo C, Kawai Y, Lindhoff-Last PDE, Kitchen S, Gosselin RC. 2021 Update of the International Council for Standardization in Haematology Recommendations for Laboratory Measurement of Direct Oral Anticoagulants. Thromb Haemost. 2021 Aug;121(8):1008-1020.

Comans AL, Sennesael AL, Bihin B, Regnier M, Mullier F, de Saint-Hubert M. Inappropriate low dosing of direct oral anticoagulants in older patients with non-valvular atrial fibrillation: Impact on plasma drug levels. Thromb Res. 2021 May;201:139-142.

Davoine C, Fillet M, Pochet L. Capillary electrophoresis as a fragment screening tool to cross-validate hits from chromogenic assay: Application to FXIIa. Talanta. 2021. Volume 226, 122163.

Lardinois B, Favresse J, Chatelain B, Lippi G, Mullier F. Pseudothrombocytopenia-A Review on Causes, Occurrence and Clinical Implications. J Clin Med. 2021 Feb 4;10(4):594.

Didembourg M, Douxfils J, Mullier F, Hardy M, Favresse J, Morimont L. Influence of C-reactive protein on thrombin generation assay. Clin Chem Lab Med. 2021 Feb 10;59(7):e301-e305.

Siriez R, Dogné JM, Gosselin R, Laloy J, Mullier F, Douxfils J. Comprehensive review of the impact of direct oral anticoagulants on thrombophilia diagnostic tests: Practical recommendations for the laboratory. Int J Lab Hematol. 2021 Feb;43(1):7-20.

Evrard J, Hardy M, Dogné JM, Lessire S, Maloteau V, Mullier F, Douxfils J. Are the DOAC plasma level thresholds appropriate for clinical decision-making? A reappraisal using thrombin generation testing. Int J Lab Hematol. 2021 Feb;43(1):e48-e51.

Hardy M, Michaux I, Lessire S, Douxfils J, Dogné JM, Bareille M, Horlait G, Bulpa P, Chapelle C, Laporte S, Testa S, Jacqmin H, Lecompte T, Dive A, Mullier F. Prothrombotic disturbances of hemostasis of patients with severe COVID-19: A prospective longitudinal observational study. Thromb Res. 2021 Jan;197:20-23.

Evrard J, Morimont L, Didembourg M, Haguet H, Siriez R, Dogné JM, Douxfils J. Assessment of acquired activated protein C resistance with the FibWave and comparison with the ETP-based APC resistance. Int J Lab Hematol. 2021 Aug;43(4):802-812.


Siriez R, Alpan L, Elasaad K, Devel P, Laloy J, Dogné JM, Douxfils J. Importance of measuring pharmacologically active metabolites of edoxaban: development and validation of an ultra-high-performance liquid chromatography coupled with a tandem mass spectrometry method. J Thromb Thrombolysis. 2020 Apr;49(3):395-403.

Hardy M, Michaux I, Lessire S, Douxfils J, Dogné JM, Bareille M, Horlait G, Bulpa P, Chapelle C, Laporte S, Testa S, Jacqmin H, Lecompte T, Dive A, Mullier F. Prothrombotic hemostasis disturbances in patients with severe COVID-19: Individual daily data. Data Brief. 2020 Dec;33:106519.

Douxfils J, Morimont L, Bouvy C. Oral Contraceptives and Venous Thromboembolism: Focus on Testing that May Enable Prediction and Assessment of the Risk. Semin Thromb Hemost. 2020 Nov;46(8):872-886.

Hardy M, Douxfils J, Dogné JM, Lessire S, Chatelain B, Testa S, Gouin-Thibault I, Gruel Y, Lecompte T, Mullier F. Management of the thrombotic risk associated with COVID-19: what is the role of the hemostasis laboratory? Ann Biol Clin (Paris). 2020 Oct 1;78(5):471-481.

Douxfils J, Klipping C, Duijkers I, Kinet V, Mawet M, Maillard C, Jost M, Rosing J, Foidart JM. Evaluation of the effect of a new oral contraceptive containing estetrol and drospirenone on hemostasis parameters. Contraception. 2020 Dec;102(6):396-402.

Hardy M, Lecompte T, Douxfils J, Lessire S, Dogné JM, Chatelain B, Testa S, Gouin-Thibault I, Gruel Y, Medcalf RL, Ten Cate H, Lippi G, Mullier F. Management of the thrombotic risk associated with COVID-19: guidance for the hemostasis laboratory. Thromb J. 2020 Sep 7;18:17.

Davoine C, Bouckaert C, Fillet M, Pochet L. Factor XII/XIIa inhibitors: Their discovery, development, and potential indications. Eur J Med Chem. 2020 Aug 20;208:112753.

Le Blanc J, Mullier F, Vayne C, Lordkipanidzé M. Advances in Platelet Function Testing-Light Transmission Aggregometry and Beyond. J Clin Med. 2020 Aug 13;9(8):E2636.

Morimont L, Bouvy C, Delvigne AS, Dogné JM, Douxfils J. Proof of concept of a new scale for the harmonization and the standardization of the ETP-based APC resistance. J Thromb Haemost. 2020 Apr;18(4):895-904.

Morimont L, Dogné JM, Douxfils J. Letter to the Editors-in-Chief in response to the article of Abou-Ismail, et al. entitled "Estrogen and thrombosis: A bench to bedside review" (Thrombosis Research 192 (2020) 40-51). Thromb Res. 2020 Aug 5;193:221-223.

Hardy M, Douxfils J, Bareille M, Lessire S, Gouin-Thibault I, Fontana P, Lecompte T, Mullier F. Studies on hemostasis in COVID-19 deserve careful reporting of the laboratory methods, their significance and their limitations. J Thromb Haemost. 2020 Aug 13:10.1111/jth.15061.

Hardy M, Lessire S, Kasikci S, Baudar J, Guldenpfennig M, Collard A, Dogné JM, Chatelain B, Jacqmin H, Lecompte T, Mullier F. Effects of Time-Interval since Blood Draw and of Anticoagulation on Platelet Testing (Count, Indices and Impedance Aggregometry): A Systematic Study with Blood from Healthy Volunteers. J Clin Med. 2020 Aug 4;9(8):E2515.

Reda S, Morimont L, Douxfils J, Rühl H. Can We Measure the Individual Prothrombotic or Prohemorrhagic Tendency by Global Coagulation Tests? Hamostaseologie. 2020 Aug;40(3):364-378.

Haguet H, Bouvy C, Delvigne AS, Modaffari E, Wannez A, Sonveaux P, Dogné JM, Douxfils J. The Risk of Arterial Thrombosis in Patients With Chronic Myeloid Leukemia Treated With Second and Third Generation BCR-ABL Tyrosine Kinase Inhibitors May Be Explained by Their Impact on Endothelial Cells: An In-Vitro Study. Front Pharmacol. 2020 Jul 3;11:1007.

Jacqmin H, Chatelain B, Louveaux Q, Jacqmin P, Dogné JM, Graux C, Mullier F. Clustering and Kernel Density Estimation for Assessment of Measurable Residual Disease by Flow Cytometry. Diagnostics (Basel). 2020 May 18;10(5):E317.

Mullier F, Paridaens MS, Evrard J, Baudar J, Guldenpfennig M, Devroye C, Miller L, Chatelain B, Lessire S, Jacqmin H. Evaluation of a new thromboplastin reagent STA-NeoPTimal on a STA R Max analyzer for the measurement of prothrombin time, international normalized ratio and extrinsic factor levels. Int J Lab Hematol. 2020 May 19.

Haguet H, Graux C, Mullier F, Dogné JM, Douxfils J. Long-Term Survival, Vascular Occlusive Events and Efficacy Biomarkers of First-Line Treatment of CML: A Meta-Analysis. Cancers (Basel). 2020 May 15;12(5):E1242.

Evrard J, Morimont L, Benyahia Z, Laloy J, Siriez R, Dogné JM, Douxfils J. Evaluation of the analytical performances of FibWave, a new sensitive tool assessing the fibrin clot formation, to measure the effects of anticoagulants. Thromb Res. 2020 Jul;191:78-81.

Tardy B, Lecompte T, Mullier F, Vayne C, Pouplard C. Detection of Platelet-Activating Antibodies Associated with Heparin-Induced Thrombocytopenia. J Clin Med. 2020 Apr 24;9(4).

Mahmoudpour SH, Valerio L, Douxfils J, Mahan CE, Jankowski M, Quitzau K, Konstantinides SV, Barco S. Potential Drug Interactions between Recombinant Interleukin-2 and Direct Oral Anticoagulants: Indirect Evidence from In Vivo Animal Studies. Hamostaseologie. 2020 Dec;40(5):679-686.

Lessire S, Dincq AS, Siriez R, Pochet L, Sennesael AL, Vornicu O, Hardy M, Deceuninck O, Douxfils J, Mullier F. Assessment of low plasma concentrations of apixaban in the periprocedural setting. Int J Lab Hematol. 2020 Aug;42(4):394-402.

Baccini V, Geneviève F, Jacqmin H, Chatelain B, Girard S, Wuilleme S, Vedrenne A, Guiheneuf E, Toussaint-Hacquard M, Everaere F, Soulard M, Lesesve JF, Bardet V. Platelet Counting: Ugly Traps and Good Advice. Proposals from the French-Speaking Cellular Hematology Group (GFHC). J Clin Med. 2020 Mar 16;9(3).

Favresse J, Boland L, Schellen M, Fervaille C, Wuestenberghs F, Camboni A, Chatelain B, Mullier F, Defour JP, Jacqmin H. Two-site evaluation of a new workflow for the detection of malignant cells on the Sysmex XN-1000 body fluid analyzer. Int J Lab Hematol. 2020 Mar 12.

Favresse J, Bayart JL, Stoefs A, Gheldof D, Douxfils J, Dogné JM, Gruson D. Neutralization of biotin interference: preliminary evaluation of the VeraTest Biotin™, VeraPrep Biotin™ and BioT-Filter®. Clin Chem Lab Med. 2020 Jul 28;58(8):e130-e133.

Féré M, Gobinet C, Liu LH, Beljebbar A, Untereiner V, Gheldof D, Chollat M, Klossa J, Chatelain B, Piot O. Implementation of a classification strategy of Raman data collected in different clinical conditions: application to the diagnosis of chronic lymphocytic leukemia. Anal Bioanal Chem. 2020 Feb;412(4):949-962.

Hardy M, Dupuis C, Dincq AS, Jacqmin H, Lecompte T, Mullier F, Lessire S. Reduction of Preoperative Waiting Time before Urgent Surgery for Patients on P2Y(12) Inhibitors Using Multiple Electrode Aggregometry: A Retrospective Study. J Clin Med. 2020 Feb 4;9(2).

Godier A, Martin AC, Lessire S, Mullier F, Leblanc I, Gouin-Thibault I. Concentrations of direct oral anticoagulants according to guidelines for the periprocedural management of low bleeding risk procedures. Anaesth Crit Care Pain Med. 2020 Feb;39(1):121-122.

Morimont L, Bouvy C, Delvigne AS, Dogné JM, Douxfils J. Proof of concept of a new scale for the harmonization and the standardization of the ETP-based APC resistance. J Thromb Haemost. 2020 Jan 26.

Harenberg J, Beyer-Westendorf J, Crowther M, Douxfils J, Elalamy I, Verhamme P, Bauersachs R, Hetjens S, Weiss C; Working Group Members. Accuracy of a Rapid Diagnostic Test for the Presence of Direct Oral Factor Xa or Thrombin Inhibitors in Urine-A Multicenter Trial. Thromb Haemost. 2020 Jan;120(1):132-140.

Douxfils J, Morimont L, Delvigne AS, Devel P, Masereel B, Haguet H, Bouvy C, Dogné JM. Validation and standardization of the ETP-based activated protein C resistance test for the clinical investigation of steroid contraceptives in women: an unmet clinical and regulatory need. Clin Chem Lab Med. 2020 Jan 28;58(2):294-305.

Alameddine R, Nassabein R, Le Gal G, Sié P, Mullier F, Blais N. Diagnosis and management of congenital thrombophilia in the era of direct oral anticoagulants. Thromb Res. 2020 Jan;185:72-77.


Favresse J, Fervaille C, Wuestenberghs F, Chatelain B, Mullier F, Jacqmin H. Utility of the XN-1000 research mode for leukocytes counting in ascitic and pleural fluids. Int J Lab Hematol. 2019 Nov 25.

Sottiaux JY, Favresse J, Chevalier C, Chatelain B, Jacqmin H, Mullier F. Evaluation of a hereditary spherocytosis screening algorithm by automated blood count using reticulocytes and erythrocytic parameters on the Sysmex XN-series. Int J Lab Hematol. 2019 Nov 22.

Bloemen S, Zwaveling S, Mullier F, Douxfils J. Concomitant assessment of rivaroxaban concentration and its impact on thrombin generation. Thromb Res. 2019 Oct 22;184:8-15.

Petrey AC, Obery DR, Kessler SP, Zawerton A, Flamion B, de la Motte CA. Platelet hyaluronidase-2 regulates the early stages of inflammatory disease in colitis. Blood. 2019 Aug 29;134(9):765-775.

Favresse J, Gruson D, Gheldof D. Comment on "High doses of biotin can interfere with immunoassays that use biotin-strept(avidin) technologies: Implications for individuals with biotin-responsive inherited metabolic disorders". Mol Genet Metab Rep. 2019 Aug 22;21:100506.

Devalet B, Wannez A, Bailly N, Alpan L, Gheldof D, Douxfils J, Bihin B, Chatelain B, Dogné JM, Chatelain C, Mullier F. Prospective and comparative study of paroxysmal nocturnal hemoglobinuria patients treated or not by eculizumab: Focus on platelet extracellular vesicles. Medicine (Baltimore). 2019 Jul;98(27):e16164.

Nieuwland R, Gardiner C, Dignat-George F, Mullier F, Mackman N, Woodhams B, Thaler J. Toward standardization of assays measuring extracellular vesicle-associated tissue factor activity. J Thromb Haemost. 2019 Aug;17(8):1261-1264.

Exner T, Favresse J, Lessire S, Douxfils J, Mullier F. Clotting test results correlate better with DOAC concentrations when expressed as a "Correction Ratio"; results before/after extraction with the DOAC Stop reagent. Thromb Res. 2019 May 2;179:69-72.

Gosselin RC, Adcock DM, Douxfils J. An update on laboratory assessment for direct oral anticoagulants (DOACs). Int J Lab Hematol. 2019 May;41 Suppl 1:33-39.

Douxfils J, Morimont L, Bouvy C, de Saint-Hubert M, Devalet B, Devroye C, Dincq AS, Dogné JM, Guldenpfennig M, Baudar J, Larock AS, Lessire S, Mullier F. Assessment of the analytical performances and sample stability on ST Genesia system using the STG-DrugScreen application. J Thromb Haemost. 2019 Aug;17(8):1273-1287.

Favresse J, Hardy M, van Dievoet MA, Sennesael AL, Douxfils J, Samama CM, Vornicu O, Dincq AS, Lessire S, Mullier F. Andexanet alfa for the reversal of factor Xa inhibitors. Expert Opin Biol Ther. 2019 May;19(5):387-397.

Barco S, Granziera S, Coppens M, Douxfils J, Nijkeuter M, Riva N, Vanassche T, Zhang G, Lin M, Kamphuisen PW, Cohen AT, Beyer-Westendorf J. Determinants of the Quality of Warfarin Control after Venous Thromboembolism and Validation of the SAMe-TT2-R2 Score: An Analysis of Hokusai-VTE. Thromb Haemost. 2019 Apr;119(4):675-684.

Wannez A, Devalet B, Chatelain B, Chatelain C, Dogné JM, Mullier F. Extracellular Vesicles in Red Blood Cell Concentrates: An Overview. Transfus Med Rev. 2019 Apr;33(2):125-130.

Evrard J, Siriez R, Morimont L, Thémans P, Laloy J, Bouvy C, Gheldof D, Mullier F, Dogné JM, Douxfils J. Optimal wavelength for the clot waveform analysis: Determination of the best resolution with minimal interference of the reagents. Int J Lab Hematol. 2019 Jun;41(3):316-324.

Siriez R, Evrard J, Dogné JM, Pochet L, Bouvy C, Lessire S, Mullier F, Douxfils J. Development of new methodologies for the chromogenic estimation of betrixaban concentrations in plasma. Int J Lab Hematol. 2019 Jan 3.


Favresse J, Lippi G, Roy PM, Chatelain B, Jacqmin H, Ten Cate H, Mullier F. D-dimer: Preanalytical, analytical, postanalytical variables, and clinical applications. Crit Rev Clin Lab Sci. 2018 Dec;55(8):548-577.

Dincq AS, Lessire S, Pirard G, Siriez R, Guldenpfennig M, Baudar J, Favresse J, Douxfils J, Mullier F. Reduction of the turn-around time for the measurement of rivaroxaban and apixaban: Assessment of the performance of a rapid centrifugation method. Int J Lab Hematol. 2018 Dec;40(6):e105-e108.

Théry C et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018 Nov 23;7(1):1535750.

Laloy J, Haguet H, Alpan L, Raichman D, Dogné JM, Lellouche JP. Impact of functional inorganic nanotubes f-INTs-WS(2) on hemolysis, platelet function and coagulation. Nano Converg. 2018 Oct 30;5(1):31.

Sennesael AL, Larock AS, Douxfils J, Elens L, Stillemans G, Wiesen M, Taubert M, Dogné JM, Spinewine A, Mullier F. Rivaroxaban plasma levels in patients admitted for bleeding events: insights from a prospective study. Thromb J. 2018 Nov 12;16:28.

Petermann R, Bakchoul T, Curtis BR, Mullier F, Miyata S, Arnold DM; Subcommittee on Platelet Immunology. Investigations for fetal and neonatal alloimmune thrombocytopenia: communication from the SSC of the ISTH. J Thromb Haemost. 2018 Dec;16(12):2526-2529.

Bloemen S, Zwaveling S, Douxfils J, Roest M, Kremers R, Mullier F. The anticoagulant effect of dabigatran is reflected in the lag time and time-to-peak, but not in the endogenous thrombin potential or peak, of thrombin generation. Thromb Res. 2018 Oct 6;171:160-166.

Farcaş E, Pochet L, Fillet M. Transverse diffusion of laminar flow profiles as a generic capillary electrophoresis method for in-line nanoreactor mixing: Application to the investigation of antithrombotic activity. Talanta. 2018 Oct 1;188:516-521.

Minet V, Evrard J, Vancraeynest C, Dogné JM, Mullier F, Pochet L. Development and validation of a liquid chromatography/tandem mass spectrometry method for the simultaneous quantification of serotonin and thromboxane B2 from activated platelets. Int J Lab Hematol. 2018 Dec;40(6):663-671.

Sennesael AL, Panin N, Vancraeynest C, Pochet L, Spinewine A, Haufroid V, Elens L. Effect of ABCB1 genetic polymorphisms on the transport of rivaroxaban in HEK293 recombinant cell lines. Sci Rep. 2018 Jul 12;8(1):10514.

Bouvy C, Wannez A, George F, Graux C, Chatelain C, Dogné JM. Circulating MicroRNAs as Biomarkers in Diffuse Large B-cell Lymphoma: A Pilot Prospective Longitudinal Clinical Study. Biomark Cancer. 2018 Jun 18;10:1179299X18781095.

van Pelt LJ, Lukens MV, Testa S, Chatelain B, Douxfils J, Mullier F. The DaXa-inhibition assay: A concept for a readily available, universal aXa assay that measures the direct inhibitory effect of all anti-Xa drugs. Thromb Res. 2018 Apr 30;168:63-66.

Siriez R, Evrard J, Dogné JM, Pochet L, Gheldof D, Chatelain B, Mullier F, Douxfils J. Betrixaban: Impact on Routine and Specific Coagulation Assays-A Practical Laboratory Guide. Thromb Haemost. 2018 Jul;118(7):1203-1214.

Favresse J, Lardinois B, Sabor L, Devalet B, Vandepapeliere J, Braibant M, Lessire S, Chatelain B, Jacqmin H, Douxfils J, Mullier F. Evaluation of the DOAC-Stop® Procedure to Overcome the Effect of DOACs on Several Thrombophilia Screening Tests. TH Open. 2018 Jun 1;2(2):e202-e209.

Favresse J, Lardinois B, Chatelain B, Jacqmin H, Mullier F. Evaluation of the Fully Automated HemosIL Acustar ADAMTS13 Activity Assay. Thromb Haemost. 2018 May;118(5):942-944.

Martin AC, Lessire S, Leblanc I, Dincq AS, Philip I, Gouin-Thibault I, Godier A. Peri-procedural management of anticoagulation for atrial fibrillation catheter ablation in direct oral anticoagulant-treated patients. Clin Cardiol. 2018 May;41(5):646-651.

Sennesael AL, Larock AS, Devalet B, Mathieux V, Verschuren F, Muschart X, Dalleur O, Dogné JM, Spinewine A. Preventability of serious thromboembolic and bleeding events related to the use of oral anticoagulants: a prospective study. Br J Clin Pharmacol. 2018 Jul;84(7):1544-1556.

Gosselin RC, Adcock DM, Bates SM, Douxfils J, Favaloro EJ, Gouin-Thibault I, Guillermo C, Kawai Y, Lindhoff-Last E, Kitchen S. International Council for Standardization in Haematology (ICSH) Recommendations for Laboratory Measurement of Direct Oral Anticoagulants. Thromb Haemost. 2018 Feb 12.

Spronk HMH, Padro T, Siland JE, Prochaska JH, Winters J, van der Wal AC, Posthuma JJ, Lowe G, d'Alessandro E, Wenzel P, Coenen DM, Reitsma PH, Ruf W, van Gorp RH, Koenen RR, Vajen T, Alshaikh NA, Wolberg AS, Macrae FL, Asquith N, Heemskerk J, Heinzmann A, Moorlag M, Mackman N, van der Meijden P, Meijers JCM, Heestermans M, Renné T, Dólleman S, Chayouâ W, Ariëns RAS, Baaten CC, Nagy M, Kuliopulos A, Posma JJ, Harrison P, Vries MJ, Crijns HJGM, Dudink EAMP, Buller HR, Henskens YMC, Själander A, Zwaveling S, Erküner O, Eikelboom JW, Gulpen A, Peeters FECM, Douxfils J, Olie RH, Baglin T, Leader A, Schotten U, Scaf B, van Beusekom HMM, Mosnier LO, van der Vorm L, Declerck P, Visser M, Dippel DWJ, Strijbis VJ, Pertiwi K, Ten Cate-Hoek AJ, Ten Cate H. Atherothrombosis and Thromboembolism: Position Paper from the Second Maastricht Consensus Conference on Thrombosis. Thromb Haemost. 2018 Feb;118(2):229-250.

Ahmed A, Kozek-Langenecker S, Mullier F, Pavord S, Hermans C; ESA VTE Guidelines Task Force. European guidelines on perioperative venous thromboembolism prophylaxis: Patients with preexisting coagulation disorders and after severe perioperative bleeding. Eur J Anaesthesiol. 2018 Feb;35(2):96-107.

Devalet B, Wannez A, Bailly N, Alpan L, Gheldof D, Douxfils J, Deneys V, Bihin B, Chatelain B, Dogné JM, Chatelain C, Mullier F. Application of a clot-based assay to measure the procoagulant activity of stored allogeneic red blood cell concentrates. Blood Transfus. 2018 Feb;16(2):163-172.

Lessire S, Douxfils J, Pochet L, Dincq AS, Larock AS, Gourdin M, Dogné JM, Chatelain B, Mullier F. Estimation of Rivaroxaban Plasma Concentrations in the Perioperative Setting in Patients With or Without Heparin Bridging. Clin Appl Thromb Hemost. 2018 Jan;24(1):129-138.

Douxfils J, Ageno W, Samama CM, Lessire S, Ten Cate H, Verhamme P, Dogné JM, Mullier F. Laboratory Testing In Patients Treated With Direct Oral Anticoagulants: A Practical Guide For Clinicians. J Thromb Haemost. 2018 Feb;16(2):209-219.


Bouvy C, Wannez A, Laloy J, Chatelain C, Dogné JM. Transfer of multidrug resistance among acute myeloid leukemia cells via extracellular vesicles and their microRNA cargo. Leuk Res. 2017 Sep 25;62:70-76.

Farcaş E, Bouckaert C, Servais AC, Hanson J, Pochet L, Fillet M. Partial filling affinity capillary electrophoresis as a useful tool for fragment-based drug discovery: A proof of concept on thrombin. Anal Chim Acta. 2017 Sep 1;984:211-222.

Vornicu O, Larock AS, Dincq AS, Douxfils J, Dogné JM, Mullier F, Lessire S. Idarucizumab for the treatment of hemorrhage and dabigatran reversal in patients requiring urgent surgery or procedures. Expert Opin Biol Ther. 2017 Oct;17(10):1275-1296.

Godier A, Dincq AS, Martin AC, Radu A, Leblanc I, Antona M, Vasse M, Golmard JL, Mullier F, Gouin-Thibault I. Predictors of pre-procedural concentrations of direct oral anticoagulants: a prospective multicentre study. Eur Heart J. 2017 Aug 14;38(31):2431-2439

Gosselin RC, Douxfils J. Measuring Direct Oral Anticoagulants. Methods Mol Biol. 2017;1646:217-225.

Bouckaert C, Zhu S, Govers-Riemslag JWP, Depoorter M, Diamond SL, Pochet L. Discovery and assessment of water soluble coumarins as inhibitors of the coagulation contact pathway. Thromb Res. 2017 Jul 19;157:126-133.

Sennesael AL, Exner T, Chatelain B, Lessire S, Larock AS, Vancraeynest C, Pochet L, Dogné JM, Spinewine A, Mullier F, Douxfils J. An optimized dRVVT-based  assay to estimate the intensity of anticoagulation in patients treated with direct oral anticoagulants. Thromb Res. 2017 Jun 28;157:29-37.

Ronez E, Geara C, Coito S, Jacqmin H, Cornet E, Troussard X, Chatelain B, Mullier F. Usefulness of thresholds for smear review of neutropenic samples analyzed with a Sysmex XN-10 analyzer. Scand J Clin Lab Invest. 2017 Oct;77(6):406-409.

Wannez A, Devalet B, Bouvy C, Laloy J, Bihin B, Chatelain B, Chatelain C, Dogné JM, Mullier F. Eculizumab decreases the procoagulant activity of extracellular vesicles in paroxysmal nocturnal hemoglobinuria: A pilot prospective longitudinal clinical study. Thromb Res. 2017 Jun 9;156:142-148.

Sabor L, Raphaël M, Dogné JM, Mullier F, Douxfils J. Heparin-calibrated chromogenic anti-Xa assays are not suitable to assess the presence of significant direct factor Xa inhibitors levels. Thromb Res. 2017 2017 Aug;156:36-38.

Gosselin RC, Gosselin R, Douxfils J, Adcock D. Clinical pearls: Laboratory assessments of direct oral anticoagulants (DOACS). Hamostaseologie. 2017 Jul 5;37(4).

Tamigniau A, Bailly N, Chatelain B, Mullier F. From XE-2100 to XN-9000, from SIS Standard to GFHC recommendations for slide review: potential impact on review rate and turnaround time. Ann Biol Clin (Paris). 2017 Jun 1;75(3):285-292.

Dubois V, Dincq AS, Douxfils J, Ickx B, Samama CM, Dogné JM, Gourdin M, Chatelain B, Mullier F, Lessire S. Perioperative management of patients on direct oral anticoagulants. Thromb J. 2017 May 15;15:14.

Minet V, Dogné JM, Mullier F. Functional Assays in the Diagnosis of Heparin-Induced Thrombocytopenia: A Review. Molecules. 2017 Apr 11;22(4).

Horlait G, Minet V, Mullier F, Michaux I. Persistent heparin-induced thrombocytopenia: danaparoid cross-reactivity or delayed-onset heparin-induced thrombocytopenia? A case report. Blood Coagul Fibrinolysis. 2017 Mar;28(2):193-197.

Hack K, Renzi F, Hess E, Lauber F, Douxfils J, Dogné JM, Cornelis GR. Inactivation of human coagulation factor X by a protease of the pathogen Capnocytophaga canimorsus. J Thromb Haemost. 2017 Mar;15(3):487-499.

Douxfils J, Gosselin RC. Laboratory Assessment of Direct Oral Anticoagulants. Semin Thromb Hemost. 2017 Apr;43(3):277-290.

Gheldof D, Haguet H, Dogné J-M, Bouvy C, Graux C, George F, Sonet A, Chatelain C, Chatelain B, Mullier F. Procoagulant activity of extracellular vesicles as a potential biomarker for risk of thrombosis and DIC in patients with acute leukaemia. J Thromb Thrombolysis. 2017 Feb;43(2):224-232.

Dincq AS, Lessire S, Chatelain B, Gourdin M, Dogné JM, Mullier F, Douxfils J. Impact of the Direct Oral Anticoagulants on Activated Clotting Time. J Cardiothorac Vasc Anesth. 2017 Feb;31(1):e24-e27.

Haguet H, Douxfils J, Mullier F, Chatelain C, Graux C, Dogné JM. Risk of arterial and venous occlusive events in chronic myeloid leukemia patients treated with new generation BCR-ABL tyrosine kinase inhibitors: A systematic review and meta-analysis. Expert Opin Drug Saf. 2017 Jan;16(1):5-12.


Vornicu O, Larock AS, Douxfils J, Mullier F, Dubois V, Dogne JM, Dincq AS. Minimisation of bleeding risks due to direct oral anticoagulants. 2016 European Medical Journal Hematology, 4(1), 78-90.

Magnette A, Chatelain M, Chatelain B, Ten Cate H, Mullier F. Pre-analytical issues in the haemostasis laboratory: guidance for the clinical laboratories. Thromb J. 2016 Dec 12;14:49.

Despas N, Larock AS, Jacqmin H, Douxfils J, Chatelain B, Chatelain M, Mullier F. Heparin monitoring: clinical outcome and practical approach. Ann Biol Clin (Paris). 2016 Dec 1;74(6):637-652.

Morel-Kopp MC, Mullier F, Gkalea V, Bakchoul T, Minet V, Elalamy I, Ward CM; subcommittee on platelet immunology. Heparin-induced multi-electrode aggregometry method for heparin-induced thrombocytopenia testing: communication from the SSC of the ISTH. J Thromb Haemost. 2016 Dec;14(12):2548-2552.

Lessire S, Douxfils J, Dincq AS, Mullier F. Periprocedural Management of Direct Oral Anticoagulants Should Be Guided by Accurate Laboratory Tests. Reg Anesth Pain Med. 2016 Nov/Dec;41(6):787-788.

Petrey AC, Obery DR, Kessler SP, Flamion B, de la Motte CA. Hyaluronan Depolymerization by Megakaryocyte Hyaluronidase-2 Is Required for Thrombopoiesis. Am J Pathol. 2016 Sep;186(9):2390-403.

Cornet E, Mullier F, Despas N, Jacqmin H, Geara C, Boubaya M, Chatelain B, Troussard X. Evaluation and optimization of the extended information process unit (E-IPU) validation module integrating the sysmex flag systems and the recommendations of the French-speaking cellular hematology group (GFHC). Scand J Clin Lab Invest. 2016 Oct;76(6):465-71.

Douxfils J, Haguet H, Dogné JM. Multiple Causes of Cardiotoxic Effects in Patients With Chronic Myeloid Leukemia-Reply. JAMA Oncol. 2016 Jun 1;2(6):829

Cai H, Mullier F, Frotscher B, Briquel ME, Toussaint M, Massin F, Lecompte T, Latger-Cannard V. Usefulness of Flow Cytometric Mepacrine Uptake/Release Combined with CD63 Assay in Diagnosis of Patients with Suspected Platelet Dense Granule Disorder. Semin Thromb Hemost. 2016 Apr;42(3):282-91.

Bouckaert C, Serra S, Rondelet G, Dolušić E, Wouters J, Dogné JM, Frédérick R, Pochet L. Synthesis, evaluation and structure-activity relationship of new 3-carboxamide coumarins as FXIIa inhibitors. Eur J Med Chem. 2016 Mar 3;110:181-94.

Douxfils J, Haguet H, Mullier F, Chatelain C, Graux C, Dogné JM. Association Between BCR-ABL Tyrosine Kinase Inhibitors for Chronic Myeloid Leukemia and Cardiovascular Events, Major Molecular Response, and Overall Survival: A Systematic Review and Meta-analysis. JAMA Oncol. 2016 Feb 4.

Douxfils J, Chatelain B, Chatelain C, Dogné JM, Mullier F. Edoxaban: Impact on routine and specific coagulation assays. A practical laboratory guide. Thromb Haemost. 2016 Jan 27;115(2):368-81.

Mullier F, Lessire S, De Schoutheete JC, Chatelain B, Deneys V, Mathieux V, Hachimi Idrissi S, Dogne JM, Watelet JB, Gourdin M, Dincq AS. Facing coagulation disorders after acute trauma. B-ENT. 2016;Suppl 26(1):67-85.


Gouin-Thibault I, Larock AS, Douxfils J, Mullier F. Which method of renal function evaluation is best appropriate in patients with direct oral anticoagulants? Ann Biol Clin (Paris). 2015 Dec 1;73(6):745-747.

Poncelet P, Robert S, Bailly N, Garnache-Ottou F, Bouriche T, Devalet B, Segatchian JH, Saas P, Mullier F. Tips and tricks for flow cytometry-based analysis and counting of microparticles. Transfus Apher Sci. 2015 Oct;53(2):110-26.

Lessire S, Douxfils J, Baudar J, Bailly N, Dincq AS, Gourdin M, Dogné JM, Chatelain B, Mullier F. Is Thrombin Time useful for the assessment of dabigatran concentrations? An in vitro and ex vivo study. Thromb Res. 2015 Sep;136(3):693-6.

Minet, V., Alpan, L., Mullier, F., Toussaint, O., Lucas, S., Dogné, J.-M., Laloy, J. The euglobulin clot lysis time to assess the impact of nanoparticles on fibrinolysis (2015) Journal of Nanoparticle Research, 17 (7), art. no. 317, 9 p.

Sennesael AL, Dogné JM, Spinewine A. Optimizing the Safe Use of Direct Oral Anticoagulants in Older Patients: A Teachable Moment. (2015) JAMA Internal Medicine, 175 (10), pp. 1608-1609.

EVpedia: A community web portal for extracellular vesicles research (2015) Bioinformatics, 31 (6), pp. 933-939.

Douxfils J, Mullier F, Dogné JM. Dose tailoring of dabigatran etexilate: obvious or excessive? Expert Opin Drug Saf. 2015 Aug;14(8):1283-9.

Douxfils J, Mani H, Minet V, Devalet B, Chatelain B, Dogné JM, Mullier F. Non-VKA Oral Anticoagulants: Accurate Measurement of Plasma Drug Concentrations. Biomed Res Int. 2015;2015:345138.

Minet V, Bailly N, Dogné JM, Mullier F. Platelet microparticle generation assay for heparin-induced thrombocytopenia diagnosis: How should we express the results? Thromb Res. 2015 Jul;136(1):175-7.

Mani H, Douxfils J, Ansell J. Target-Specific Oral Anticoagulants-New Approaches in the Field of Oral Anticoagulation. Biomed Res Int. 2015;2015:549803.

Onclinx C, Dogne S, Jadin L, Andris F, Grandfils C, Jouret F, Mullier F, Flamion B. Deficiency in mouse hyaluronidase 2: a new mechanism of chronic thrombotic microangiopathy. Haematologica 2015 Aug;100(8):1023-30.

Mullier F, Douxfils J, Tamigniau A, Dogné JM, Horellou MH, Flaujac C, Chatelain B, Goffinet C, Samama MM, Gouin-Thibault I. Non-VKA oral anticoagulants: an update for the clinical biologists Ann Biol Clin (Paris). 2015 May-Jun;73(3):333-44.

Devalet B, Mullier F, Chatelain B, Dogné JM, Chatelain C. Pathophysiology, diagnosis, and treatment of paroxysmal nocturnal hemoglobinuria: a review. Eur J Haematol. 2015 Sep;95(3):190-8.

Douxfils J, Chatelain B, Hjemdahl P, Devalet B, Sennesael AL, Wallemacq P, Rönquist-Nii Y, Pohanka A, Dogné JM, Mullier F. Does the Russell Viper Venom time test provide a rapid estimation of the intensity of oral anticoagulation? A cohort study. Thromb Res. 2015 May;135(5):852-60.

Douxfils J, Chatelain B, Dogné JM, Mullier F. Real-world variability in dabigatran levels in patients with. atrial fibrillation: comment J Thromb Haemost. 2015 Jun;13(6):1166-8.

Douxfils J, Lessire S, Dincq AS, Hjemdahl P, Rönquist-Nii Y, Pohanka A, Gourdin M, Chatelain B, Dogné JM, Mullier F. Estimation of dabigatran plasma concentrations in the perioperative setting. An ex vivo study using dedicated coagulation assays. Thromb Haemost. 2015 Apr;113(4):862-9.


Douxfils J, Tamigniau A, Chatelain B, Goffinet C, Dogné JM, Mullier F. Measurement of non-VKA oral anticoagulants versus classic ones: the appropriate use of hemostasis assays. Thromb J. 2014 Nov 4;12:24.

Larock AS, Mullier F, Sennesael AL, Douxfils J, Devalet B, Chatelain C, Dogné JM, Spinewine A. Appropriateness of prescribing dabigatran etexilate and rivaroxaban in patients with nonvalvular atrial fibrillation: a prospective study. Ann Pharmacother. 2014 Oct;48(10):1258-68.

Devalet B, Mullier F, Chatelain B, Dogné JM, Chatelain C. The central role of extracellular vesicles in the mechanisms of thrombosis in paroxysmal nocturnal haemoglobinuria: a review. J Extracell Vesicles. 2014 Mar 24;3.

Bouvy C, Gheldof D, Chatelain C, Mullier F, Dogne JM. Contributing role of extracellular vesicles on vascular endothelium haemostatic balance in cancer. Journal of extracellular vesicles 2014, 3.

Dincq AS, Lessire S, Douxfils J, Dogne JM, Gourdin M, Mullier F Management of Non-Vitamin K Antagonist Oral Anticoagulants in the Perioperative Setting. BioMed research international 2014, 2014:385014.

Douxfils J, Buckinx F, Mullier F, Minet V, Rabenda V, Reginster JY, Hainaut P, Bruyere O, Dogne JM Dabigatran etexilate and risk of myocardial infarction, other cardiovascular events, major bleeding, and all-cause mortality: a systematic review and meta-analysis of randomized controlled trials. Journal of the American Heart Association 2014, 3:e000515.

Gheldof D, Chatelain C, Dogne JM, Mullier F Microparticle-associated tissue factor activity and overt disseminated intravascular coagulation in patients with acute myelocytic leukemia. Thrombosis research 2014, 134:213-214.

Gheldof D, Mullier F, Bailly N, Devalet B, Dogne JM, Chatelain B, Chatelain C Microparticle bearing tissue factor: a link between promyelocytic cells and hypercoagulable state. Thrombosis research 2014, 133:433-439.

Minet V, Baudar J, Bailly N, Douxfils J, Laloy J, Lessire S, Gourdin M, Devalet B, Chatelain B, Dogné JM, Mullier F. Rapid exclusion of the diagnosis of immune HIT by AcuStar HIT and heparin-induced multiple electrode aggregometry. Thrombosis research 2014, 133:1074-1078.

Mullier F, Minet V, Bailly N, Devalet B, Douxfils J, Chatelain C, Elalamy I, Dogne JM, Chatelain B Platelet microparticle generation assay: a valuable test for immune heparin-induced thrombocytopenia diagnosis. Thrombosis research 2014, 133:1068-1073.

Mullier F, Vanpee D, Jamart J, Dubuc E, Bailly N, Douxfils J, Chatelain C, Dogne JM, Chatelain B Comparison of five D-dimer reagents and application of an age-adjusted cut-off for the diagnosis of venous thromboembolism in emergency department. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2014, 25:309-315.

Lessire, S., Dincq, A.-S., Douxfils, J., Devalet, B., Nicolas, J.-B., Spinewine, A., Larock, A.-S., Dogné, J.-M., Gourdin, M., Mullier, F. Preventive strategies against bleeding due to nonvitamin K antagonist oral anticoagulants (2014) BioMed Research International, 2014, art. no. 616405.

Tamigniau, A., Douxfils, J., Nicolas, J.-B., Devalet, B., Larock, A.-S., Spinewine, A., Dincq, A.-S., Lessire, S., Gourdin, M., Watelet, J.-B., Mathieux, V., Chatelain, C., Dogné, J.-M., Chatelain, B., Mullier, F. Why, when and how monitor new oral anticoagulants? [Pourquoi, quand et comment doser les nouveaux anticoagulants oraux?] (2014) Revue Medicale Suisse, 10 (416), pp. 326-333.

J Laloy, V Minet, L Alpan, F Mullier, S Beken, O Toussaint, S Lucas and J-M Dogné. Impact of Silver Nanoparticles on Haemolysis, Platelet Function and Coagulation. Nanobiomedicine, 2014, 1:4.


Douxfils J, Tamigniau A, Chatelain B, Chatelain C, Wallemacq P, Dogne JM, Mullier F Comparison of calibrated chromogenic anti-Xa assay and PT tests with LC-MS/MS for the therapeutic monitoring of patients treated with rivaroxaban. Thrombosis and haemostasis 2013, 110:723-731.

Douxfils J, Chatelain C, Chatelain B, Dogne JM, Mullier F Impact of apixaban on routine and specific coagulation assays: a practical laboratory guide. Thrombosis and haemostasis 2013, 110:283-294.

Douxfils J, Dogne JM, Mullier F, Chatelain B, Ronquist-Nii Y, Malmstrom RE, Hjemdahl P Comparison of calibrated dilute thrombin time and aPTT tests with LC-MS/MS for the therapeutic monitoring of patients treated with dabigatran etexilate. Thrombosis and haemostasis 2013, 110:543-549.

Gheldof D, Mullier F, Chatelain B, Dogne JM, Chatelain C Inhibition of tissue factor pathway inhibitor increases the sensitivity of thrombin generation assay to procoagulant microvesicles. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2013, 24:567-572.

Gheldof D, Hardij J, Cecchet F, Chatelain B, Dogne JM, Mullier F Thrombin generation assay and transmission electron microscopy: a useful combination to study tissue factor-bearing microvesicles. Journal of extracellular vesicles 2013 Mar 18;2.

Hardij J, Cecchet F, Berquand A, Gheldof D, Chatelain C, Mullier F, Chatelain B, Dogne JM Characterisation of tissue factor-bearing extracellular vesicles with AFM: comparison of air-tapping-mode AFM and liquid Peak Force AFM Journal of extracellular vesicles 2013, Aug 27;2.

Minet V, Bailly N, Douxfils J, Osselaer JC, Laloy J, Chatelain C, Elalamy I, Chatelain B, Dogne JM, Mullier F Assessment of the performances of AcuStar HIT and the combination with heparin-induced multiple electrode aggregometry: a retrospective study Thrombosis research 2013, 132:352-359.

Mullier F, Bailly N, Chatelain C, Chatelain B, Dogne JM Pre-analytical issues in the measurement of circulating microparticles: current recommendations and pending questions. Journal of thrombosis and haemostasis : JTH 2013, 11:693-696.

Pochet L, Servais AC, Farcas E, Bettonville V, Bouckaert C, Fillet M Determination of inhibitory potency of argatroban toward thrombin by electrophoretically mediated microanalysis Talanta 2013, 116:719-725.


Mullier F, Rahier JF, Maignen F, Cornet Y, Graux C, Chatelain C, Chatelain B, Dogne JM A case of therapy-related myeloid neoplasm in a patient with Crohn's disease treated with azathioprine Acta haematologica 2012, 128:1-6.

Douxfils J, Mullier F, Loosen C, Chatelain C, Chatelain B, Dogne JM Assessment of the impact of rivaroxaban on coagulation assays: laboratory recommendations for the monitoring of rivaroxaban and review of the literature Thrombosis research 2012, 130:956-966.

Douxfils J, Mullier F, Robert S, Chatelain C, Chatelain B, Dogne JM Impact of dabigatran on a large panel of routine or specific coagulation assays. Laboratory recommendations for monitoring of dabigatran etexilate Thrombosis and haemostasis 2012, 107:985-997.

Laloy J, Robert S, Marbehant C, Mullier F, Mejia J, Piret JP, Lucas S, Chatelain B, Dogné JM, Toussaint O, Masereel B, Rolin S. Validation of the calibrated thrombin generation test (cTGT) as the reference assay to evaluate the procoagulant activity of nanomaterials. Nanotoxicology 2012, 6:213-232.

Mullier F, Bailly N, Cornet Y, Robert S, Osselaer JC, Chatelain C, Elalamy I, Dogne JM, Chatelain B Platelet microparticle generation assay: A valuable predictor of clinical outcome in heparin-induced thombocytopenia diagnosis. Immuno-analyse&biologie spécialisée 2012, 27:41.

Mullier F, Daliphard S, Garand R, Dekeyser M, Cornet Y, Luquet I, Talmant P, Richebourg S, Jamar M, Dogné JM, Chatelain C, Michaux L, Chatelain B. Morphology, cytogenetics, and survival in myelodysplasia with del(20q) or ider(20q): a multicenter study Annals of hematology 2012, 91:203-213.

Mullier F, Daliphard S, Garand R, Dekeyser M, Cornet Y, Luquet I, Talmant P, Richebourg S, Jamar M, Dogne JM, Chatelain C, Michaux L, Chatelain B. Hypogranulated and vacuolized neutrophils and neutrophil erythrophagocytosis is a useful marker in myelodysplasia with del(20q): A multicentre stydy. Immuno-analyse&biologie spécialisée 2012, 27:42-43.

Mullier F, Laloy J, Robert S, Alpan L, Meija J, Piret J, Bailly N, Lucas S, Chatelain B, Toussaint O, B. Masereel, S. Rolin & JM Dogne. Assessment of different methods studying the impact of carbon nanomaterials on platelet function Immuno-analyse Biologie Spécialisée 2012, 27:41.

Mullier F, Vanpee D, Amart J, Dubuc E, Cornet Y, Chatelain C, Dogne JM, Chatelain B Comparison of five D-dimer reagents and application of an age adjusted cut-off for the diagnosis of venous thromboembolic disease in emergency departement Immuno-analyse&biologie spécialisée 2012, 27:42.

Mullier F, Varin E, Gheldof D, Hardij J, Robert S, Bailly N, Devel P, Doyen C, Chatelain C, Michiels C, Chatelain B, Dogne JM Thrombin generation, flow cytometry and electron microscopy is a useful combination to study tissue-factor bearing microparticles in thrombosis associated with breast cancer Immuno-analyse&biologie spécialisée 2012, 27:43.

Sternotte A, Douxfils J, Chatelain B, Chatelain C, Mullier F, Dogne JM, Spinewine A [Clinical studies, the interests and limits of using dabigatran in atrial fibrillation] Journal de pharmacie de Belgique 2012:8-17.


Mullier F, Bailly N, Chatelain C, Dogné JM, Chatelain B. More on: calibration for the measurement of microparticles:Needs, interests, and limitations of calibrated polystyrene beads for flow cytometry-based quantification of biological microparticles.  Thromb Haemost. 2011 Aug;9(8):1679-81; author reply 1681-2.

Mullier F, Lainey E, Fenneteau O, Da Costa L, Schillinger F, Bailly N, Cornet Y, Chatelain C, Dogne JM, Chatelain B. Additional erythrocytic and reticulocytic parameters helpful for diagnosis of hereditary spherocytosis: results of a multicentre study. Ann Hematol, 2011 Jul;90(7):759-68.