Ayama-Canden S, Tondo R, Pineros Leyton ML, Ninane N, Demazy C, Dieu M, Fattaccioli A, Sauvage A, Tabarrant T, Lucas S, Bonifazi D, Michiels C. Indacaterol inhibits collective cell migration and IGDQ-mediated single cell migration in metastatic breast cancer MDA-MB-231 cells. Cell Commun Signal. 2023 Oct 30;21(1):301.

Díaz-Anaya AM, Gerard L, Albert M, Gaussin JF, Boonen M, Gillet JP. The β Isoform of Human ATP-Binding Cassette B5 Transporter, ABCB5β, Localizes to the Endoplasmic Reticulum. Int J Mol Sci. 2023 Oct 31;24(21):15847.

Duvivier L, Gerard L, Diaz A, Gillet JP. Linking ABC transporters to the hallmarks of cancer. Trends Cancer. 2023 Oct 24:S2405-8033(23)00197-8.

Douxfils J, Beaudart C, Dogné JM. Risk of neoplasm with the neurokinin 3 receptor antagonist fezolinetant. Lancet. 2023 Oct 18:S0140-6736(23)01634-3.

Reynders C, Lerho T, Goebel EA, Crum CP, Vandenput S, Beaudart C, Herfs M. Prevalence and genotype distribution of human papillomavirus in cervical adenocarcinoma (usual type and variants): A systematic review and meta-analysis. J Med Virol. 2023 Oct;95(10):e29190.

Bonito CA, Ferreira RJ, Ferreira MU, Durães F, Sousa E, Gillet JP, Cordeiro MNDS, Dos Santos DJVA. Probing the Allosteric Modulation of P-Glycoprotein: A Medicinal Chemistry Approach Toward the Identification of Noncompetitive P-Gp Inhibitors. ACS Omega. 2023 Mar 14;8(12):11281-11287.

Bonito CA, Ferreira RJ, Ferreira MU, Gillet JP, Cordeiro MNDS, Dos Santos DJVA. Long-range communication between transmembrane- and nucleotide-binding domains does not depend on drug binding to mutant P-glycoprotein. J Biomol Struct Dyn. 2023 Mar 1:1-10.

Schifflers C, Zottnick S, Förster JD, Kruse S, Yang R, Wiethoff H, Bozza M, Hoppe-Seyler K, Heikenwälder M, Harbottle RP, Michiels C, Riemer AB. Development of an Orthotopic HPV16-Dependent Base of Tongue Tumor Model in MHC-Humanized Mice. Pathogens. 2023 Jan 25;12(2):188.

Bruyere D, Roncarati P, Lebeau A, Lerho T, Poulain F, Hendrick E, Pilard C, Reynders C, Ancion M, Luyckx M, Renard M, Jacob Y, Twizere JC, Peiffer R, Peulen O, Delvenne P, Hubert P, McBride A, Gillet N, Masson M, Herfs M. Human papillomavirus E6/E7 oncoproteins promote radiotherapy-mediated tumor suppression by globally hijacking host DNA damage repair. Theranostics. 2023 Jan 31;13(3):1130-1149.

Lejeune N, Mathieu S, Decloux A, Poulain F, Blockx Z, Raymond KA, Willemart K, Vartanian JP, Suspène R, Gillet NA. The APOBEC3B cytidine deaminase is an adenovirus restriction factor. PLoS Pathog. 2023 Feb 6;19(2):e1011156.

Ternad I, Penninckx S, Lecomte V, Vangijzegem T, Conrard L, Lucas S, Heuskin AC, Michiels C, Muller RN, Stanicki D, Laurent S. Advances in the Mechanistic Understanding of Iron Oxide Nanoparticles' Radiosensitizing Properties. Nanomaterials (Basel). 2023 Jan 2;13(1):201.


Delprat V, Huart C, Feron O, Soncin F, Michiels C. The impact of macrophages on endothelial cells is potentiated by cycling hypoxia: Enhanced tumor inflammation and metastasis. Front Oncol. 2022 Sep 28;12:961753.

Blackman MCNM, Capeloa T, Rondeau JD, Zampieri LX, Benyahia Z, Van de Velde JA, Fransolet M, Daskalopoulos EP, Michiels C, Beauloye C, Sonveaux P. Mitochondrial Protein Cox7b Is a Metabolic Sensor Driving Brain-Specific Metastasis of Human Breast Cancer Cells. Cancers (Basel). 2022 Sep 8;14(18):4371.

Gilloteaux DJ, Jamison JM, Summers JL, Taper HS. Xenografts on nude mouse diaphragm of human DU145 prostate carcinoma cells: mesothelium removal by outgrowths and angiogenesis. Ultrastruct Pathol. 2022 Sep 3;46(5):413-438.

Ronvaux L, Riva M, Coosemans A, Herzog M, Rommelaere G, Donis N, D'Hondt L, Douxfils J. Liquid Biopsy in Glioblastoma. Cancers (Basel). 2022 Jul 13;14(14):3394.

Duvivier L, Gillet JP. Deciphering the roles of ABCB5 in normal and cancer cells. Trends in Cancer. 2022 Oct;8(10):795-798.

Ayama-Canden S, Tondo R, Piñeros L, Ninane N, Demazy C, Dieu M, Fattaccioli A, Tabarrant T, Lucas S, Bonifazi D, Michiels C. IGDQ motogenic peptide gradient induces directional cell migration through integrin (αv)β3 activation in MDA-MB-231 metastatic breast cancer cells. Neoplasia. 2022 Jun 25;31:100816.

Chasseur AS, Trozzi G, Istasse C, Petit A, Rasschaert P, Denesvre C, Kaufer BB, Bertzbach LD, Muylkens B, Coupeau D. Marek's Disease Virus Virulence Genes Encode Circular RNAs. J Virol. 2022 May 11;96(9):e0032122.

Capeloa T, Krzystyniak J, d'Hose D, Canas Rodriguez A, Payen VL, Zampieri LX, Van de Velde JA, Benyahia Z, Pranzini E, Vazeille T, Fransolet M, Bouzin C, Brusa D, Michiels C, Gallez B, Murphy MP, Porporato PE, Sonveaux P. MitoQ Inhibits Human Breast Cancer Cell Migration, Invasion and Clonogenicity. Cancers (Basel). 2022 Mar 16;14(6):1516.

Huart C, Fransolet M, Demazy C, Le Calvé B, Lucas S, Michiels C, Wéra AC. Taking Advantage of the Senescence-Promoting Effect of Olaparib after X-ray and Proton Irradiation Using the Senolytic Drug, ABT-263. Cancers (Basel). 2022 Mar 12;14(6):1460.

Lothaire P, Uzureau P, Boudjelta Kz, Nagy N, Michiels C, Carletti T. Estimation of the fractal dimension of thyroid nodules as a complementary diagnostic tool for predicting malignancy. Journal of Cancer Science and Clinical Therapeutics 6 (2022): 1-15.

Thabault L, Brustenga C, Savoyen P, Van Gysel M, Wouters J, Sonveaux P, Frédérick R, Liberelle M. Discovery of small molecules interacting at lactate dehydrogenases tetrameric interface using a biophysical screening cascade. Eur J Med Chem. 2022 Jan 12;230:114102.

Brahimi-Horn MC, Lacas-Gervais S, Adaixo R, Ilc K, Rouleau M, Notte A, Dieu M, Michiels C, Voeltzel T, Maguer-Satta V, Pelletier J, Ilie M, Hofman P, Manoury B, Schmidt A, Hiller S, Pouysségur J, Mazure NM. Erratum for Brahimi-Horn et al., "Local Mitochondrial-Endolysosomal Microfusion Cleaves the Voltage-Dependent Anion Channel 1 To Promote Survival in Hypoxia". Mol Cell Biol. 2022 Jan 20;42(1):e0051521.


Penninckx S, Hespeels F, Smeets J, Colaux JL, Lucas S, Heuskin A-C. Metallic Nanoparticles: A Useful Prompt Gamma Emitter for Range Monitoring in Proton Therapy? Radiation. 2021; 1(4):305-316.

Duchemin A, O'Grady T, Hanache S, Mereau A, Thiry M, Wacheul L, Michaux C, Perpète E, Hervouet E, Peixoto P, Ernst FGM, Audic Y, Dequiedt F, Lafontaine DLJ, Mottet D. DHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity. Nat Commun. 2021 Nov 17;12(1):6648.

Faure-Dupuy S, Riedl T, Rolland M, Hizir Z, Reisinger F, Neuhaus K, Schuehle S, Remouchamps C, Gillet N, Schönung M, Stadler M, Wettengel J, Barnault R, Parent R, Schuster LC, Farhat R, Prokosch S, Leuchtenberger C, Öllinger R, Engleitner T, Rippe K, Rad R, Unger K, Tscharahganeh D, Lipka DB, Protzer U, Durantel D, Lucifora J, Dejardin E, Heikenwälder M. Control of APOBEC3B induction and cccDNA decay by NF-κB and miR-138-5p. JHEP Rep. 2021 Aug 25;3(6):100354.

Daems N, Michiels C, Lucas S, Baatout S, Aerts A. Gold nanoparticles meet medical radionuclides. Nucl Med Biol. 2021 Sep-Oct;100-101:61-90.

Gennart I, Petit A, Wiggers L, Pejaković S, Dauchot N, Laurent S, Coupeau D, Muylkens B. Epigenetic Silencing of MicroRNA-126 Promotes Cell Growth in Marek’s Disease. Microorganisms. 2021; 9(6):1339.

Lejeune N, Poulain F, Willemart K, Blockx Z, Mathieu S, Gillet NA. Infection of bronchial epithelial cells by the human adenoviruses A12, B3 and C2 differently regulates the innate antiviral effector APOBEC3B. J Virol. 2021 Jun 10;95(13):e0241320.

Delprat V, Michiels C. A bi-directional dialog between vascular cells and monocytes/macrophages regulates tumor progression. Cancer Metastasis Rev. 2021 Jun;40(2):477-500.

Bury M, Le Calvé B, Ferbeyre G, Blank V, Lessard F. New Insights into CDK Regulators: Novel Opportunities for Cancer Therapy. Trends Cell Biol. 2021 May;31(5):331-344.

Gerard L, Duvivier L, Gillet JP. Targeting tumor resistance mechanisms. Fac Rev. 2021 Jan 26;10:6.

Thabault L, Liberelle M, Koruza K, Yildiz E, Joudiou N, Messens J, Brisson L, Wouters J, Sonveaux P, Frédérick R. Discovery of a novel lactate dehydrogenase tetramerization domain using epitope mapping and peptides. J Biol Chem. 2021 Feb 16:100422.

Roessner PM, Llaó Cid L, Lupar E, Roider T, Bordas M, Schifflers C, Arseni L, Gaupel AC, Kilpert F, Krötschel M, Arnold SJ, Sellner L, Colomer D, Stilgenbauer S, Dietrich S, Lichter P, Izcue A, Seiffert M. EOMES and IL-10 regulate antitumor activity of T regulatory type 1 CD4+ T cells in chronic lymphocytic leukemia. Leukemia. 2021 Aug;35(8):2311-2324.


Mirgaux M, Leherte L, Wouters J. Influence of the presence of the heme cofactor on the JK-loop structure in indoleamine 2,3-dioxygenase 1. Acta Crystallogr D Struct Biol. 2020 Dec 1;76(Pt 12):1211-1221.

Henthorn N, Sokol O, Durante M, De Marzi L, Pouzoulet F, Miszczyk J, Olko P, Brandenburg S, van Goethem MJ, Barazzuol L, Tambas M, Langendijk J, Davídková M, Vondráĉek V, Bodenstein E, Pawelke J, Lomax A, Weber D, Dasu A, Stenerlöw B, Poulsen P, Sørensen B, Grau C, Sitarz M, Heuskin AC, Lucas S, Warmenhoven J, Merchant M, Mackay R, Kirkby K. Mapping the Future of Particle Radiobiology in Europe: The INSPIRE Project. Frontiers in Physics 2020, 8, 438.

Pariset E, Penninckx S, Kerbaul CD, Guiet E, Macha AL, Cekanaviciute E, Snijders AM, Mao JH, Paris F, Costes SV. 53BP1 Repair Kinetics for Prediction of In Vivo Radiation Susceptibility in 15 Mouse Strains. Radiat Res. 2020 Nov 10;194(5):485-499.

Penninckx S, Pariset E, Acuna AU, Lucas S, Costes SV. Considering Cell Proliferation to Optimize Detection of Radiation-Induced 53BP1-Positive Foci in 15 Mouse Strains Ex Vivo. Radiat Res. 2020 Nov 12.

Daems N, Verlinden B, Van Hoecke K, Cardinaels T, Baatout S, Michiels C, Lucas S, Aerts A. In Vivo Pharmacokinetics, Biodistribution and Toxicity of Antibody-Conjugated Gold Nanoparticles in Healthy Mice. J Biomed Nanotechnol. 2020 Jun 1;16(6):985-996.

Pejaković S, Mbouombouo Mfossa AC, Wiggers L, Kheimar A, Coupeau D, Kaufer BB, Muylkens B. Role of DNA methylation and CpG sites in the viral telomerase RNA promoter during Gallid herpesvirus 2 pathogenesis. J Virol. 2020 Sep 23:JVI.01488-20.

Poulain F, Lejeune N, Willemart K, Gillet NA. Footprint of the host restriction factors APOBEC3 on the genome of human viruses. PLoS Pathog. 2020 Aug 14;16(8):e1008718.

Penninckx S, Heuskin AC, Michiels C, Lucas S. Gold Nanoparticles as a Potent Radiosensitizer: A Transdisciplinary Approach from Physics to Patient. Cancers (Basel). 2020 Jul 23;12(8):E2021.

Haguet H, Bouvy C, Delvigne AS, Modaffari E, Wannez A, Sonveaux P, Dogné JM, Douxfils J. The Risk of Arterial Thrombosis in Patients With Chronic Myeloid Leukemia Treated With Second and Third Generation BCR-ABL Tyrosine Kinase Inhibitors May Be Explained by Their Impact on Endothelial Cells: An In-Vitro Study. Front Pharmacol. 2020 Jul 3;11:1007.

Pineux F, Federico S, Klotz KN, Kachler S, Michiels C, Sturlese M, Prato M, Spalluto G, Moro S, Bonifazi D. Targeting G Protein-Coupled Receptors with Magnetic Carbon Nanotubes: The Case of the A3 Adenosine Receptor. ChemMedChem. 2020 Oct 19;15(20):1909-1920.

André MPE, Carde P, Viviani S, Bellei M, Fortpied C, Hutchings M, Gianni AM, Brice P, Casasnovas O, Gobbi PG, Zinzani PL, Dupuis J, Iannitto E, Rambaldi A, Brière J, Clément-Filliatre L, Heczko M, Valagussa P, Douxfils J, Depaus J, Federico M, Mounier N. Long-term overall survival and toxicities of ABVD vs BEACOPP in advanced Hodgkin lymphoma: A pooled analysis of four randomized trials. Cancer Med. 2020 Sep;9(18):6565-6575.

Huart C, Chen JW, Le Calvé B, Michiels C, Wéra AC. Could Protons and Carbon Ions Be the Silver Bullets Against Pancreatic Cancer? Int J Mol Sci. 2020 Jul 4;21(13):E4767.

Bonito CA, Ferreira RJ, Ferreira MU, Gillet JP, Cordeiro MNDS, Dos Santos DJVA. Theoretical insights on helix repacking as the origin of P-glycoprotein promiscuity. Sci Rep. 2020 Jun 17;10(1):9823.

Haguet H, Graux C, Mullier F, Dogné JM, Douxfils J. Long-Term Survival, Vascular Occlusive Events and Efficacy Biomarkers of First-Line Treatment of CML: A Meta-Analysis. Cancers (Basel). 2020 May 15;12(5):E1242.

Longton E, Lawson G, Bihin B, Mathieu I, Hanin FX, Deheneffe S, Vander Borght T, Laloux M, Daisne JF. Individualized Prophylactic Neck Irradiation in Patients with cN0 Head and Neck Cancer Based on Sentinel Lymph Node(s) Identification: Definitive Results of a Prospective Phase 1-2 Study. Int J Radiat Oncol Biol Phys. 2020 Jul 15;107(4):652-661.

Schuemann J, Bagley A, Berbeco R, Bromma K, Butterworth KT, Byrne H, Chithrani DB, Cho SH, Cook JR, Favaudon V, Gholami YH, Gargioni E, Hainfeld JF, Hespeels F, Heuskin AC, Ibeh UM, Kuncic Z, Kunjachan S, Lacombe S, Lucas S, Lux F, McMahon SJ, Nevozhay D, Ngwa W, Payne JD, Penninckx S, Porcel E, Prise KM, Rabus H, Ridwan SM, Rudek B, Sanche L, Singh B, Smilowitz HM, Sokolov KV, Sridhar S, Stanishevskiy Y, Sung W, Tillement O, Virani NA, Yantasee W, Krishnan S. Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions. Phys Med Biol. 2020 May 7.

Canonne M, Wanet A, Nguyen TTA, Khelfi A, Ayama-Canden S, Van Steenbrugge M, Fattaccioli A, Sokal E, Najimi M, Arnould T, Renard P. MPV17 does not control cancer cell proliferation. PLoS One. 2020 Mar 10;15(3):e0229834.

Carvalho A, Viaene J, Vandenbussche G, De Braekeleer K, Masereel B, Wouters J, Souard F, Vander Heyden Y, Van Antwerpen P, Delporte C, Mathieu V. A new potential anti-cancer beta-carboline derivative decreases the expression levels of key proteins involved in glioma aggressiveness: A proteomic investigation. Drug Dev Res. 2020 Feb;81(1):32-42.

Corbet C, Bastien E, Santiago de Jesus JP, Dierge E, Martherus R, Vander Linden C, Doix B, Degavre C, Guilbaud C, Petit L, Michiels C, Dessy C, Larondelle Y, Feron O. TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells. Nat Commun. 2020 Jan 23;11(1):454.

Delprat V, Tellier C, Demazy C, Raes M, Feron O, Michiels C. Cycling hypoxia promotes a pro-inflammatory phenotype in macrophages via JNK/p65 signaling pathway. Sci Rep. 2020 Jan 21;10(1):882.


Özcan-Wahlbrink M, Schifflers C, Riemer AB. Enhanced Radiation Sensitivity of Human Papillomavirus-Driven Head and Neck Cancer: Focus on Immunological Aspects. Front Immunol. 2019 Dec 3;10:2831.

Schmit K, Chen JW, Ayama-Canden S, Fransolet M, Finet L, Demazy C, D'Hondt L, Graux C, Michiels C. Characterization of the role of TMEM45A in cancer cell sensitivity to cisplatin. Cell Death Dis. 2019 Dec 4;10(12):919.

Bury M, Le Calvé B, Lessard F, Dal Maso T, Saliba J, Michiels C, Ferbeyre G, Blank V. NFE2L3 Controls Colon Cancer Cell Growth through Regulation of DUX4, a CDK1 Inhibitor. Cell Rep. 2019 Nov 5;29(6):1469-1481.e9.

Marx S, Dal Maso T, Chen JW, Bury M, Wouters J, Michiels C, Le Calvé B. Transmembrane (TMEM) protein family members: Poorly characterized even if essential for the metastatic process. Semin Cancer Biol. 2019 Aug 24.

Daems N, Penninckx S, Nelissen I, Van Hoecke K, Cardinaels T, Baatout S, Michiels C, Lucas S, Aerts A. Gold nanoparticles affect the antioxidant status in selected normal human cells. Int J Nanomedicine. 2019 Jul 8;14:4991-5015.

Wéra AC, Lobbens A, Stoyanov M, Lucas S, Michiels C. Radiation-induced synthetic lethality: combination of poly(ADP-ribose) polymerase and RAD51 inhibitors to sensitize cells to proton irradiation. Cell Cycle. 2019 Jun 25:1-14.

Dubaere E, Goffaux M, Wanet M, Bihin B, Gheldof C, Demoulin AS, Bolly A, Bustin F, Duplaquet F, Baugnee PE, Gustin M, Hers V, Maisin F, Marchand E, Ocak S, Pirard L, Vancutsem O, Van Neck E, Vandermoten G, Zaharia L, Remouchamps V. Long term outcome after 48 Gy stereotactic ablative body radiotherapy for peripheral stage I non-small cell lung cancer. BMC Cancer. 2019 Jun 28;19(1):639.

Hespeels F, Heuskin AC, Tabarrant T, Scifoni E, Kraemer M, Chêne G, Strivay D, Lucas S. Backscattered electron emission after proton impact on gold nanoparticles with and without polymer shell coating. Phys Med Biol. 2019 Apr 15.

Marx S, Bodart L, Tumanov N, Wouters J. Design and Synthesis of a New Soluble Natural β-Carboline Derivative for Preclinical Study by Intravenous Injection. Int J Mol Sci. 2019 Mar 25;20(6).

Sana G, Madigan JP, Gartner JJ, Fourrez M, Lin J, Qutob N, Narayan J, Shukla S, Ambudkar SV, Xia D, Rosenberg SA, Gottesman MM, Samuels Y, Gillet JP. Exome sequencing of ABCB5 identifies recurrent melanoma mutations that result in increased proliferative and invasive capacities. J Invest Dermatol. 2019 Sep;139(9):1985-1992.e10.

Penninckx S, Heuskin AC, Michiels C, Lucas S. Thioredoxin Reductase Activity Predicts Gold Nanoparticle Radiosensitization Effect. Nanomaterials (Basel). 2019 Feb 19;9(2).

Hespeels F, Lucas S, Tabarrant T, Scifoni E, Kraemer M, Chêne G, Strivay D, Tran HN, Heuskin AC. Experimental measurements validate the use of the binary encounter approximation model to accurately compute proton induced dose and radiolysis enhancement from gold nanoparticles. Phys Med Biol. 2019 Feb 7.

Li S, Bouchy S, Penninckx S, Marega R, Fichera O, Gallez B, Feron O, Martinive P, Heuskin AC, Michiels C, Lucas S. Antibody-functionalized gold nanoparticles as tumor targeting radiosensitizers for proton therapy. Nanomedicine (Lond). 2019 Feb;14(3):317-333.

Marx S, Van Gysel M, Breuer A, Dal Maso T, Michiels C, Wouters J, Le Calvé B. Potentialization of anticancer agents by identification of new chemosensitizers active under hypoxia. Biochem Pharmacol. 2019 Apr;162:224-236.

Deschênes-Simard X, Parisotto M, Rowell MC, Le Calvé B, Igelmann S, Moineau-Vallée K, Saint-Germain E, Kalegari P, Bourdeau V, Kottakis F, Bardeesy N, Ferbeyre G. Circumventing senescence is associated with stem cell properties and metformin sensitivity. Aging Cell. 2019 Apr;18(2):e12889.


Gilloteaux, J., Jamison, J., Arnold, D., & Summers, J. Autoschizis: A Mode of Cell Death of Cancer Cells Induced by a Prooxidant Treatment In Vitro and In Vivo: The Many Ways Cells Die. 2018 Dans J. A. Radosevich (Ed.), Apoptosis and Beyond Wiley-Blackwell.

Schmit K, Michiels C. TMEM Proteins in Cancer: A Review. Front Pharmacol. 2018 Dec 6;9:1345.

Penninckx S, Heuskin AC, Michiels C, Lucas S. The role of thioredoxin reductase in gold nanoparticle radiosensitization effects. Nanomedicine (Lond). 2018 Nov;13(22):2917-2937.

Longton E, Schmit K, Fransolet M, Clement F, Michiels C. Appropriate Sequence for Afatinib and Cisplatin Combination Improves Anticancer Activity in Head and Neck Squamous Cell Carcinoma. Front Oncol. 2018 Oct 5;8:432.

Édeline V, Remouchamps V, Isnardi V, Vander Borght T. Multimodality imaging using PET/CT ((18)F)-fluorodeoxyglucose for radiotherapy field delineation of localized Hodgkin lymphoma. Cancer Radiother. 2018 Sep;22(5):384-392.

Berriolo-Riedinger A, Becker S, Casasnovas O, Vander Borght T, Édeline V. Role of FDG PET-CT in the treatment management of Hodgkin lymphoma. Cancer Radiother. 2018 Sep;22(5):393-400.

Bouvy C, Wannez A, George F, Graux C, Chatelain C, Dogné JM. Circulating MicroRNAs as Biomarkers in Diffuse Large B-cell Lymphoma: A Pilot Prospective Longitudinal Clinical Study. Biomark Cancer. 2018 Jun 18;10:1179299X18781095.

Genard G, Wera AC, Huart C, Le Calve B, Penninckx S, Fattaccioli A, Tabarrant  T, Demazy C, Ninane N, Heuskin AC, Lucas S, Michiels C. Proton irradiation orchestrates macrophage reprogramming through NFκB signaling. Cell Death Dis. 2018 Jun 27;9(7):728.

Toutfaire M, Dumortier E, Fattaccioli A, Van Steenbrugge M, Proby CM, Debacq-Chainiaux F. Unraveling the interplay between senescent dermal fibroblasts and cutaneous squamous cell carcinoma cell lines at different stages of tumorigenesis. Int J Biochem Cell Biol. 2018 Mar 14;98:113-126.

Cook LB, Rowan AG, Demontis MA, Sagawe S, Gillet NA, Melamed A, Greiller C, Witkover A, Bangham CRM, Taylor GP. Long-term clinical remission maintained after cessation of zidovudine and interferon-α therapy in chronic adult T-cell leukemia/lymphoma. Int J Hematol. 2018 Mar;107(3):378-382.

Castrogiovanni C, Waterschoot B, De Backer O, Dumont P. Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis. Cell Death Differ. 2018 Jan;25(1):190-203.


Hinz T, Kallen K, Britten CM, Flamion B, Granzer U, Hoos A, Huber C, Khleif S, Kreiter S, Rammensee HG, Sahin U, Singh-Jasuja H, Türeci Ö, Kalinke U. The European Regulatory Environment of RNA-Based Vaccines. Methods Mol Biol. 2017;1499:203-222.

Bouvy C, Wannez A, Laloy J, Chatelain C, Dogné JM. Transfer of multidrug resistance among acute myeloid leukemia cells via extracellular vesicles and their microRNA cargo. Leuk Res. 2017 Sep 25;62:70-76.

Rondelet G, Fleury L, Faux C, Masson V, Dubois J, Arimondo PB, Willems L, Wouters J. Inhibition studies of DNA methyltransferases by maleimide derivatives of RG108 as non-nucleoside inhibitors. Future Med Chem. 2017 Sep;9(13):1465-1481.

Heuskin AC, Gallez B, Feron O, Martinive P, Michiels C, Lucas S. Metallic nanoparticles irradiated by low energy protons for radiation therapy: are there significant physical effects to enhance the dose delivery? Med Phys. 2017 Aug;44(8):4299-4312.

Genard G, Lucas S, Michiels C. Reprogramming of Tumor-Associated Macrophages with Anticancer Therapies: Radiotherapy versus Chemo- and Immunotherapies. Front Immunol. 2017 Jul 14;8:828.

Baldini N, De Milito A, Feron O, Gillies RJ, Michiels C, Otto AM, Pastoreková S, Pedersen SF, Porporato PE, Sonveaux P, Supuran CT, Avnet S. Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Networks in Cancer. Front Pharmacol. 2017 Jul 4;8:411.

Rondelet G, Wouters J. Human DNA (cytosine-5)-methyltransferases: A functional and structural perspective for epigenetic cancer therapy. Biochimie. 2017 Aug;139:137-147.

Carvalho A, Chu J, Meinguet C, Kiss R, Vandenbussche G, Masereel B, Wouters J, Kornienko A, Pelletier J, Mathieu V. Data in support of a harmine-derived beta-carboline in vitro effects in cancer cells through protein synthesis. Data Brief. 2017 May 5;12:546-551.

Verdon Q, Boonen M, Ribes C, Jadot M, Gasnier B, Sagné C. SNAT7 is the primary lysosomal glutamine exporter required for extracellular protein-dependent growth of cancer cells. Proc Natl Acad Sci U S A. 2017 May 2;114(18):E3602-E3611.

Carvalho A, Chu J, Meinguet C, Kiss R, Vandenbussche G, Masereel B, Wouters J, Kornienko A, Pelletier J, Mathieu V. A harmine-derived beta-carboline displays anti-cancer effects in vitro by targeting protein synthesis. Eur J Pharmacol. 2017 Jun 15;805:25-35.

Gheldof D, Haguet H, Dogné J-M, Bouvy C, Graux C, George F, Sonet A, Chatelain C, Chatelain B, Mullier F. Procoagulant activity of extracellular vesicles as a potential biomarker for risk of thrombosis and DIC in patients with acute leukaemia. J Thromb Thrombolysis. 2017 Feb;43(2):224-232.

Frère A, Baroni A, Hendrick E, Delvigne AS, Orange F, Peulen O, Dakwar GR, Diricq J, Dubois P, Evrard B, Remaut K, Braeckmans K, De Smedt SC, Laloy J, Dogné JM, Feller G, Mespouille L, Mottet D, Piel G. PEGylated and Functionalized Aliphatic Polycarbonate Polyplex Nanoparticles for Intravenous Administration of  HDAC5 siRNA in Cancer Therapy. ACS Appl Mater Interfaces. 2017 Jan 25;9(3):2181-2195.

Haguet H, Douxfils J, Mullier F, Chatelain C, Graux C, Dogné JM. Risk of arterial and venous occlusive events in chronic myeloid leukemia patients treated with new generation BCR-ABL tyrosine kinase inhibitors: A systematic review and meta-analysis. Expert Opin Drug Saf. 2017 Jan;16(1):5-12.


Crott R, Lawson G, Nollevaux MC, Castiaux A, Krug B. Comprehensive cost analysis of sentinel node biopsy in solid head and neck tumors using a time-driven activity-based costing approach. Eur Arch Otorhinolaryngol. 2016 Sep;273(9):2621-8.

Li S, Penninckx S, Karmani L, Heuskin AC, Watillon K, Marega R, Zola J, Corvaglia V, Genard G, Gallez B, Feron O, Martinive P, Bonifazi D, Michiels C, Lucas S. LET-dependent radiosensitization effects of gold nanoparticles for proton irradiation. Nanotechnology. 2016 Nov 11;27(45):455101.

Brisson L, Bański P, Sboarina M, Dethier C, Danhier P, Fontenille MJ, Van Hée VF, Vazeille T, Tardy M, Falces J, Bouzin C, Porporato PE, Frédérick R, Michiels C, Copetti T, Sonveaux P. Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer. Cancer Cell. 2016 Sep 12;30(3):418-31.

Glorieux C, Sandoval JM, Fattaccioli A, Dejeans N, Garbe JC, Dieu M, Verrax J, Renard P, Huang P, Calderon PB. Chromatin remodeling regulates catalase expression during cancer cells adaptation to chronic oxidative stress. Free Radic Biol Med. 2016 Aug 31;99:436-450.

Marega R, Prasetyanto EA, Michiels C, De Cola L, Bonifazi D. Fast Targeting and Cancer Cell Uptake of Luminescent Antibody-Nanozeolite Bioconjugates. Small. 2016 Oct;12(39):5431-5441.

Michiels C, Tellier C, Feron O. Cycling hypoxia: A key feature of the tumor microenvironment. Biochim Biophys Acta. 2016 Aug;1866(1):76-86.

Heuskin AC, Osseiran AI, Tang J, Costes SV. Simulating Space Radiation-Induced Breast Tumor Incidence Using Automata. Radiat Res. 2016 Jul;186(1):27-38.

Le Calvé B, Griveau A, Vindrieux D, Maréchal R, Wiel C, Svrcek M, Gout J, Azzi L, Payen L, Cros J, de la Fouchardière C, Dubus P, Guitton J, Bartholin L, Bachet JB, Bernard D. Lysyl oxidase family activity promotes resistance of pancreatic ductal adenocarcinoma to chemotherapy by limiting the intratumoral anticancer drug distribution. Oncotarget. 2016 May 31;7(22):32100-12.

Karmani L, Levêque P, Bouzin C, Bol A, Dieu M, Walrand S, Vander Borght T, Feron O, Grégoire V, Bonifazi D, Michiels C, Lucas S, Gallez B. Biodistribution of (125)I-labeled anti-endoglin antibody using SPECT/CT imaging: Impact of in vivo deiodination on tumor accumulation in mice. Nucl Med Biol. 2016 Mar 29;43(7):415-423.

Gillet JP, Andersen JB, Madigan JP, Varma S, Bagni RK, Powell K, Burgan WE, Wu CP, Calcagno AM, Ambudkar SV, Thorgeirsson SS, Gottesman MM. A Gene Expression Signature Associated with Overall Survival in Patients with Hepatocellular Carcinoma Suggests a New Treatment Strategy Mol Pharmacol. 2016 Feb;89(2):263-72.

Gottesman MM, Lavi O, Hall MD, Gillet JP. Toward a Better Understanding of the Complexity of Cancer Drug Resistance. Annu Rev Pharmacol Toxicol. 2016 Jan 6;56:85-102.

Corvaglia V, Marega R, De Leo F, Michiels C, Bonifazi D. Cancer Cells: Unleashing Cancer Cells on Surfaces Exposing Motogenic IGDQ Peptides. Small. 2016 Jan 20;12(3):321-9.

Leclere L., Fransolet M., Cambier P., El Bkassiny S., Tikad A., Dieu M., Vincent S.P., Van Cutsem P., Michiels C. Identification of a cytotoxic molecule in heat-modified citrus pectin (2016) Carbohydrate Polymers, 137, pp. 39-51.


Corvaglia V, Marega R, De Leo F, Michiels C, Bonifazi D. Unleashing Cancer Cells on Surfaces Exposing Motogenic IGDQ Peptides. Small. 2015 Nov 19.

Genin M, Clement F, Fattaccioli A, Raes M, Michiels C. M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide. BMC Cancer. 2015 Aug 8;15:577.

Meinguet C, Masereel B, Wouters J. Preparation and characterization of a new harmine-based antiproliferative compound in complex with cyclodextrin: Increasing solubility while maintaining biological activity. Eur J Pharm Sci. 2015 Sep 18;77:135-40.

Gennart I, Coupeau D, Pejaković S, Laurent S, Rasschaert D, Muylkens B. Marek's disease: Genetic regulation of gallid herpesvirus 2 infection and latency. Vet J. 2015 Sep;205(3):339-48.

Lucas S, Feron O, Gallez B, Masereel B, Michiels C, Vander Borght T. Monte Carlo Calculation of Radioimmunotherapy with (90)Y-, (177)Lu-, (131)I-, (124)I-, and (188)Re-Nanoobjects: Choice of the Best Radionuclide for Solid Tumour Treatment by Using TCP and NTCP Concepts. Comput Math Methods Med. 2015;2015:284360.

Van Tongelen, A., Loriot, A., De Backer, O., De Smet, C. Application of CRISPR/cas9-Directed Homologous Recombination to the Generation of Human Tumor Cells with Conditional Knockout of an X-Linked MicroRNA Locus. Gene Technology 2015 July 4:124 pp 2329-6682

Brohée L, Demine S, Willems J, Arnould T, Colige AC, Deroanne CF. Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment. Oncotarget. 2015 May 10;6(13):11264-80.

Notte A, Rebucci M, Fransolet M, Roegiers E, Genin M, Tellier C, Watillon K, Fattaccioli A, Arnould T, Michiels C. Taxol-induced unfolded protein response activation in breast cancer cells exposed to hypoxia: ATF4 activation regulates autophagy and inhibits apoptosis. Int J Biochem Cell Biol. 2015 May;62:1-14.

Brahimi-Horn MC, Lacas-Gervais S, Adaixo R, Ilc K, Rouleau M, Notte A, Dieu M, Michiels C, Voeltzel T, Maguer-Satta V, Pelletier J, Ilie M, Hofman P, Manoury B, Schmidt A, Hiller S, Pouysségur J, Mazure NM. Local mitochondrial-endolysosomal microfusion cleaves voltage-dependent anion channel 1 to promote survival in hypoxia. Mol Cell Biol. 2015 May;35(9):1491-505.

Rebucci M, Sermeus A, Leonard E, Delaive E, Dieu M, Fransolet M, Arnould T, Michiels C miRNA-196b inhibits cell proliferation and induces apoptosis in HepG2 cells by targeting IGF2BP1. Mol Cancer. 2015 Apr 8;14(1):79.

Meinguet C, Bruyère C, Frédérick R, Mathieu V, Vancraeynest C, Pochet L, Laloy J, Mortier J, Wolber G, Kiss R, Masereel B, Wouters J. 3D-QSAR, design, synthesis and characterization of trisubstituted harmine derivatives with in vitro antiproliferative properties. Eur J Med Chem. 2015 Apr 13;94:45-55.

Leclere L, Fransolet M, Cote F, Cambier P, Arnould T, Van Cutsem P, Michiels C. Heat-Modified Citrus Pectin Induces Apoptosis-Like Cell Death and Autophagy in HepG2 and A549 Cancer Cells. PLoS One. 2015 Mar 20;10(3).

Riquier H, Abel D, Wera AC, Heuskin AC, Genard G, Lucas S, Michiels C. Effects of Alpha Particle and Proton Beam Irradiation as Putative Cross-Talk between A549 Cancer Cells and the Endothelial Cells in a Co-Culture System Cancers (Basel). 2015 Mar 18;7(1):481-502.

Tellier C, Desmet D, Petit L, Finet L, Graux C, Raes M, Feron O, Michiels C. Cycling hypoxia induces a specific amplified inflammatory phenotype in endothelial cells and enhances tumor-promoting inflammation in vivo. Neoplasia. 2015 Jan;17(1):66-78.


Sid B, Glorieux C, Valenzuela M, Rommelaere G, Najimi M, Dejeans N, Renard P, Verrax J, Calderon PB. AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells. Biochem Pharmacol. 2014 Sep 15;91(2):168-80.

Keniya MV, Holmes AR, Niimi M, Lamping E, Gillet JP, Gottesman MM, Cannon RD. Drug resistance is conferred on the model yeast Saccharomyces cerevisiae by expression of full-length melanoma-associated human ATP-binding cassette transporter ABCB5. Mol Pharm. 2014 Oct 6;11(10):3452-62.

Daisne JF, Installé J, Bihin B, Laloux M, Vander Borght T, Mathieu I, Lawson G. SPECT/CT lymphoscintigraphy of sentinel node(s) for superselective prophylactic irradiation of the neck in cN0 head and neck cancer patients: a prospective phase I feasibility study. Radiat Oncol. 2014 May 28;9:121.

Karmani L, Bouchat V, Bouzin C, Levêque P, Labar D, Bol A, Deumer G, Marega R, Bonifazi D, Haufroid V, Michiels C, Grégoire V, Feron O, Lucas S, Vander Borght T, Gallez B. (89)Zr-labeled anti-endoglin antibody-targeted gold nanoparticles for imaging cancer: implications for future cancer therapy. Nanomedicine (Lond). 2014 Sep;9(13):1923-37.

Bouvy C, Gheldof D, Chatelain C, Mullier F, Dogne JM Contributing role of extracellular vesicles on vascular endothelium haemostatic balance in cancer. Journal of extracellular vesicles 2014, Jul 11;3.

De Meulder B, Berger F, Bareke E, Depiereux S, Michiels C, Depiereux E Meta-analysis and gene set analysis of archived microarrays suggest implication of the spliceosome in metastatic and hypoxic phenotypes. PloS one 2014, 9:e86699.

Serra S, Moineaux L, Vancraeynest C, Masereel B, Wouters J, Pochet L, Frederick R Thiosemicarbazide, a fragment with promising indolamine-2,3-dioxygenase (IDO) inhibition properties. European journal of medicinal chemistry 2014, 82:96-105.

Heuskin AC, Michiels C, Lucas S Low dose hypersensitivity following in vitro cell irradiation with charged particles: Is the mechanism the same as with X-ray radiation? International journal of radiation biology 2014, 90:81-89.

Porporato PE, Payen VL, Pérez-Escuredo J, De Saedeleer CJ, Danhier P, Copetti T, Dhup S, Tardy M, Vazeille T, Bouzin C, Feron O, Michiels C, Gallez B, Sonveaux P. A mitochondrial switch promotes tumor metastasis. Cell Rep. 2014 Aug 7;8(3):754-66.


Karmani L, Labar D, Valembois V, Bouchat V, Nagaswaran PG, Bol A, Gillart J, Levêque P, Bouzin C, Bonifazi D, Michiels C, Feron O, Grégoire V, Lucas S, Vander Borght T, Gallez B. Antibody-functionalized nanoparticles for imaging cancer: influence of conjugation to gold nanoparticles on the biodistribution of 89Zr-labeled cetuximab in mice. Contrast Media Mol Imaging. 2013 Sep-Oct;8(5):402-8.

Britten CM, Singh-Jasuja H, Flamion B, Hoos A, Huber C, Kallen KJ, Khleif SN, Kreiter S, Nielsen M, Rammensee HG, Sahin U, Hinz T, Kalinke U. The regulatory landscape for actively personalized cancer immunotherapies. Nature biotechnology 2013, 31:880-882.

Heuskin AC, Michiels C, Lucas S Toward computer simulation of high-LET in vitro survival curves Physics in medicine and biology 2013, 58:6495-6510.

Heuskin AC, Wera AC, Riquier H, Michiels C, Lucas S Low-Dose Hypersensitivity and Bystander Effect are Not Mutually Exclusive in A549 Lung Carcinoma Cells after Irradiation with Charged Particles Radiation research 2013, 180:491-498.

Leclere L, Cutsem PV, Michiels C Anti-cancer activities of pH- or heat-modified pectin. Frontiers in pharmacology 2013, 4:128.

Notte A, Ninane N, Arnould T, Michiels C Hypoxia counteracts taxol-induced apoptosis in MDA-MB-231 breast cancer cells: role of autophagy and JNK activation Cell death & disease 2013, 4:e638.

Ranasinghe WK, Xiao L, Kovac S, Chang M, Michiels C, Bolton D, Shulkes A, Baldwin GS, Patel O The role of hypoxia-inducible factor 1alpha in determining the properties of castrate-resistant prostate cancers PloS one 2013, 8:e54251.

Rebucci M, Michiels C Molecular aspects of cancer cell resistance to chemotherapy. Biochemical pharmacology 2013, 85:1219-1226.

Riquier H, Wera AC, Heuskin AC, Feron O, Lucas S, Michiels C Comparison of X-ray and alpha particle effects on a human cancer and endothelial cells: survival curves and gene expression profiles Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2013, 106:397-403.

Sermeus A, Rebucci M, Fransolet M, Flamant L, Desmet D, Delaive E, Arnould T, Michiels C Differential effect of hypoxia on etoposide-induced DNA damage response and p53 regulation in different cell types Journal of cellular physiology 2013, 228:2365-2376.

Wera AC, Heuskin AC, Riquier H, Michiels C, Lucas S Low-LET proton irradiation of A549 non-small cell lung adenocarcinoma cells: dose response and RBE determination. Radiation research 2013, 179:273-281.


Flamant L, Roegiers E, Pierre M, Hayez A, Sterpin C, De Backer O, Arnould T, Poumay Y, Michiels C TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells BMC cancer 2012, 12:391.

Frederick R, Bruyere C, Vancraeynest C, Reniers J, Meinguet C, Pochet L, Backlund A, Masereel B, Kiss R, Wouters J Novel trisubstituted harmine derivatives with original in vitro anticancer activity Journal of medicinal chemistry 2012, 55:6489-6501.

Mahjoubi K, Destiné M, Palumbo S, Huyskens D, Daisne JF EP-1474 Clinical evaluation of an adaptative radiotherapy software on a head and neck cancer population. Radiotherapy and Oncology 2012, 103:s563.

Pilotte L, Larrieu P, Stroobant V, Colau D, Dolusic E, Frédérick R, De Plaen E, Uyttenhove C, Wouters J, Masereel B, Van den Eynde BJ. Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase Proceedings of the National Academy of Sciences of the United States of America 2012, 109:2497-2502.

Moineaux L, Laurent S, Reniers J, Dolusic E, Galleni M, Frere JM, Masereel B, Frederick R, Wouters J Synthesis, crystal structures and electronic properties of isomers of chloro-pyridinylvinyl-1H-indoles European journal of medicinal chemistry 2012, 54:95-102.

Mullier F, Varin E, Gheldof D, Hardij J, Robert S, Bailly N, Devel P, Doyen C, Chatelain C, Michiels C, Chatelain B, Dogne JM Thrombin generation, flow cytometry and electron microscopy is a useful combination to study tissue-factor bearing microparticles in thrombosis associated with breast cancer Immuno-analyse&biologie spécialisée 2012, 27:43.

Sermeus A, Genin M, Maincent A, Fransolet M, Notte A, Leclere L, Riquier H, Arnould T, Michiels C Hypoxia-induced modulation of apoptosis and BCL-2 family proteins in different cancer cell types PloS one 2012, 7:e47519.

Van Overstraeten-Schlogel N, Shim YH, Tevel V, Piel G, Piette J, Dubois P, Raes M Assessment of new biocompatible poly(N-(morpholino)ethyl methacrylate)-based copolymers by transfection of immortalized keratinocytes. Drug delivery 2012, 19:112-122.

Mullier F, Rahier JF, Maignen F, Cornet Y, Graux C, Chatelain C, Chatelain B, Dogne JM A case of therapy-related myeloid neoplasm in a patient with Crohn's disease treated with azathioprine Acta haematologica 2012, 128:1-6.

Marega, R., Karmani, L., Flamant, L., Nageswaran, P.G., Valembois, V., Masereel, B., Feron, O., Borght, T.V., Lucas, S., Michiels, C., Gallez, B., Bonifazi, D. Antibody-functionalized polymer-coated gold nanoparticles targeting cancer cells: An in vitro and in vivo study (2012) Journal of Materials Chemistry, 22 (39), pp. 21305-21312.

Wéra AC, Borlon C, Nuttens VE, Riquier H, Feron O, Michiels C, Lucas S. Comparison of the clonogenic survival of A549 non-small cell lung adenocarcinoma cells after irradiation with low-dose-rate beta particles and high-dose-rate X-rays. Int J Radiat Biol. 2012 Mar;88(3):253-7.


Synthesis and inhibition study of monoamine oxidase, indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase by 3,8-substituted 5H-indeno[1,2-c]pyridazin-5-one derivatives. J. Reniers, C. Meinguet, L. Moineaux, B. Masereel, S.P. Vincent, R. Frederick, J. Wouters. European Journal of Medicinal Chemistry, Volume 46, Issue 12, December 2011, Pages 6104-6111.

Tryptophan 2,3-Dioxygenase (TDO) Inhibitors. 3-(2-(Pyridyl)ethenyl)indoles as Potential Anticancer Immunomodulators. Eduard Dolusic, Pierre Larrieu, Laurence Moineaux, Vincent Stroobant, Luc Pilotte, Didier Colau, Lionel Pochet, Benoît Van den Eynde, Bernard Masereel, Johan Wouters, and Raphaël Frédérick. J. Med. Chem., 2011, 54 (15), pp 5320–5334.

Autophagy as a mediator of chemotherapy-induced cell death in cancer. Notte A, Leclere L, Michiels C. Biochem Pharmacol. 2011 Sep 1;82(5):427-34.

An NTCP Analysis of Urethral Complications from Low Doserate Mono- and Bi-Radionuclide Brachytherapy. V.Nuttens, E.Nahum and S. Lucas. Prostate Cancer. Volume 2011 (2011), Article ID 128360, 9 pages.

Reciprocal influence of the p53 and the hypoxic pathways. Sermeus A, Michiels C.  Cell Death Dis. 2011 May 26;2:e164.

Pierre, M., DeHertogh, B., DeMeulder, B., Bareke, E., Depiereux, S., Michiels, C., Depiereux, E.  Enhanced meta-analysis highlights genes involved in metastasis from several microarray datasets. In Journal of Proteomics and Bioinformatics, Volume 4, Issue 2, 2011, Pages 36-43.


Cosse JP, Rommelaere G, Ninane N, Arnould T, Michiels C. BNIP3 protects HepG2 cells against etoposide-induced cell death under hypoxia by an autophagy-independent pathway. Biochem Pharmacol. 2010 Oct 15;80(8):1160-9.

Flamant L, Notte A, Ninane N, Raes M, Michiels C. Anti-apoptotic role of HIF-1 and AP-1 in paclitaxel exposed breast cancer cells under hypoxia. Mol Cancer.  2010 Jul 13;9:191.