Diabetes, obesity, kidney & metabolism



Juszczak F, Pierre L, Decarnoncle M, Jadot I, Martin B, Botton O, Caron N, Dehairs J, Swinnen JV, Declèves AE. Sex differences in obesity-induced renal lipid accumulation revealed by lipidomics: a role of adiponectin/AMPK axis. Biol Sex Differ. 2023 Sep 28;14(1):63.

Neumann M, Arnould T, Su BL. Encapsulation of stem-cell derived β-cells: A promising approach for the treatment for type 1 diabetes mellitus. J Colloid Interface Sci. 2023 Apr 15;636:90-102.

Barrueta Tenhunen A, van der Heijden J, Dogné S, Flamion B, Weigl W, Frithiof R, Skorup P, Larsson A, Larsson A, Tenhunen J. High molecular weight hyaluronan - a potential adjuvant to fluid resuscitation in abdominal sepsis? Shock. 2023 May 1;59(5):763-770.


Puissant E, Gilis F, Tevel V, Vandeweerd JM, Flamion B, Jadot M, Boonen M. Hyaluronidase 1 deficiency decreases bone mineral density in mice. Sci Rep. 2022 Jun 16;12(1):10142.


Baudoux T, Jadot I, Declèves AE, Antoine MH, Colet JM, Botton O, De Prez E, Pozdzik A, Husson C, Caron N, Nortier JL. Experimental Aristolochic Acid Nephropathy: A Relevant Model to Study AKI-to-CKD Transition. Front Med (Lausanne). 2022 May 4;9:822870.

Gilloteaux J, Nicaise C, Sprimont L, Bissler J, Finkelstein JA, Payne WR. Leptin receptor defect with diabetes causes skeletal muscle atrophy in female obese Zucker rats where peculiar depots networked with mitochondrial damages. Ultrastruct Pathol. 2021 Nov 2;45(6):346-375.

Zhu Y, Li N, Huang M, Bartels M, Dogné S, Zhao S, Chen X, Crewe C, Straub L, Vishvanath L, Zhang Z, Shao M, Yang Y, Gliniak CM, Gordillo R, Smith GI, Holland WL, Gupta RK, Dong B, Caron N, Xu Y, Akgul Y, Klein S, Scherer PE. Adipose tissue hyaluronan production improves systemic glucose homeostasis and primes adipocytes for CL 316,243-stimulated lipolysis. Nat Commun. 2021 Aug 10;12(1):4829.

Kerr ID, Hutchison E, Gerard L, Aleidi SM, Gelissen IC. Mammalian ABCG-transporters, sterols and lipids: To bind perchance to transport? Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Mar;1866(3):158860.

Del Marmol D, Holtze S, Kichler N, Sahm A, Bihin B, Bourguignon V, Dogné S, Szafranski K, Hildebrandt TB, Flamion B. Abundance and size of hyaluronan in naked mole-rat tissues and plasma. Sci Rep. 2021 Apr 12;11(1):7951.

Uzureau S, Lecordier L, Uzureau P, Hennig D, Graversen JH, Homblé F, Mfutu PE, Oliveira Arcolino F, Ramos AR, La Rovere RM, Luyten T, Vermeersch M, Tebabi P, Dieu M, Cuypers B, Deborggraeve S, Rabant M, Legendre C, Moestrup SK, Levtchenko E, Bultynck G, Erneux C, Pérez-Morga D, Pays E. APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin. Cell Rep. 2020 Mar 17;30(11):3821-3836.e13.

Braude S, Holtze S, Begall S, Brenmoehl J, Burda H, Dammann P, Del Marmol D, Gorshkova E, Henning Y, Hoeflich A, Höhn A, Jung T, Hamo D, Sahm A, Shebzukhov Y, Šumbera R, Miwa S, Vyssokikh MY, von Zglinicki T, Averina O, Hildebrandt TB. Surprisingly long survival of premature conclusions about naked mole-rat biology. Biol Rev Camb Philos Soc. 2021 Apr;96(2):376-393.


Juszczak F, Vlassembrouck M, Botton O, Zwakhals T, Decarnoncle M, Tassin A, Caron N, Declèves AE. Delayed Exercise Training Improves Obesity-Induced Chronic Kidney Disease by Activating AMPK Pathway in High-Fat Diet-Fed Mice. Int J Mol Sci. 2020 Dec 31;22(1):350.

Juszczak F, Caron N, Mathew AV, Declèves AE. Critical Role for AMPK in Metabolic Disease-Induced Chronic Kidney Disease. Int J Mol Sci. 2020 Oct 27;21(21):E7994.

Dogné S, Flamion B. Endothelial glycocalyx impairment in disease: Focus on hyaluronan shedding. Am J Pathol. 2020 Apr;190(4):768-780.


Petrey AC, Obery DR, Kessler SP, Zawerton A, Flamion B, de la Motte CA. Platelet hyaluronidase-2 regulates the early stages of inflammatory disease in colitis. Blood. 2019 Aug 29;134(9):765-775.


Gilloteaux J, Subramanian K, Solomon N, Nicaise C. The leptin receptor mutation of the obese Zucker rat causes sciatic nerve demyelination with a centripetal pattern defect. Ultrastruct Pathol. 2018 Sep-Oct;42(5):377-408.

Dogné S, Flamion B, Caron N. Endothelial Glycocalyx as a Shield Against Diabetic Vascular Complications: Involvement of Hyaluronan and Hyaluronidases. Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1427-1439.

Kehoe K, Noels H, Theelen W, De Hert E, Xu S, Verrijken A, Arnould T, Fransen E, Hermans N, Lambeir AM, Venge P, Van Gaal L, De Meester I. Prolyl carboxypeptidase activity in the circulation and its correlation with body weight and adipose tissue in lean and obese subjects. PLoS One. 2018 May 17;13(5):e0197603.

Baudoux T, Husson C, De Prez E, Jadot I, Antoine MH, Nortier JL, Hougardy JM. CD4(+) and CD8(+) T Cells Exert Regulatory Properties During Experimental Acute Aristolochic Acid Nephropathy. Sci Rep. 2018 Mar 28;8(1):5334.

Demine S, Tejerina S, Bihin B, Thiry M, Reddy N, Renard P, Raes M, Jadot M, Arnould T. Mild mitochondrial uncoupling induces HSL/ATGL-independent lipolysis relying on a form of autophagy in 3T3-L1 adipocytes. J Cell Physiol. 2018 Feb;233(2):1247-1265.

Martin B, Caron N, Jadot I, Colombaro V, Federici G, Depommier C, Declèves AÉ. Evaluation of inducible nitric oxide synthase inhibition on kidney function and structure in high-fat diet-induced kidney disease. Exp Physiol. 2018 Jan 1;103(1):125-140.


Jadot I, Colombaro V, Martin B, Habsch I, Botton O, Nortier J, Declèves AE, Caron N. Restored nitric oxide bioavailability reduces the severity of acute-to-chronic transition in a mouse model of aristolochic acid nephropathy. PLoS One. 2017 Aug 23;12(8):e0183604.

Jadot I, Declèves AE, Nortier J, Caron N. An Integrated View of Aristolochic Acid Nephropathy: Update of the Literature. Int J Mol Sci. 2017 Jan 29;18(2).


Dogné S, Rath G, Jouret F, Caron N, Dessy C, Flamion B. Hyaluronidase 1 deficiency preserves endothelial function and glycocalyx integrity in early streptozotocin-induced diabetes. Diabetes. 2016 Sep;65(9):2742-53.

Bourguignon V, Flamion B. Respective roles of hyaluronidases 1 and 2 in endogenous hyaluronan turnover. FASEB J. 2016 Jun;30(6):2108-14.

Declèves AÉ, Jadot I, Colombaro V, Martin B, Voisin V, Nortier J, Caron N. Protective effect of nitric oxide in aristolochic acid-induced toxic acute kidney injury: an old friend with new assets. Exp Physiol. 2016 Jan;101(1):193-206.

VIEWPOINT: Gewin L. NO clue to pathogenesis of aristolochic acid nephropathy. Exp Physiol. 2016 Jan;101(1):33. Comment on Exp Physiol. 2016 Jan;101(1):193-206. Protective effect of nitric oxide in aristolochic acid-induced toxic acute kidney injury: an old friend with new assets.

Malaisse J, Pendaries V, Hontoir F, De Glas V, Van Vlaender D, Simon M, Lambert de Rouvroit C, Poumay Y, Flamion B. Hyaluronan does not regulate human epidermal keratinocyte proliferation and differentiation. J Biol Chem. 2016 Mar 18;291(12):6347-58.

Petrey AC, Obery DR, Kessler SP, Flamion B, de la Motte CA. Hyaluronan Depolymerization by Megakaryocyte Hyaluronidase-2 Is Required for Thrombopoiesis. Am J Pathol. 2016 Sep;186(9):2390-403.


Colombaro V, Jadot I, Declèves AE, Voisin V, Giordano L, Habsch I, Malaisse J, Flamion B, Caron N. Lack of hyaluronidases exacerbates renal post-ischemic injury, inflammation, and fibrosis. Kidney Int. 2015 Jul;88(1):61-71.

Colombaro V, Jadot I, Declèves AE, Voisin V, Giordano L, Habsch I, Flamion B, Caron N. Hyaluronidase 1 and hyaluronidase 2 are required for renal hyaluronan turnover. Acta Histochem. 2015 Jan;117(1):83-91.


Voisin V, Decleves A, Hubert V, Colombaro V, Giordano L, Habsch I, Bouby N, Nonclercq D, Caron N Protection of Wistar-Furth rats from post-ischemic acute renal injury: a role for Nitric Oxide and Thromboxane? Clinical and experimental pharmacology & physiology 2014 Nov;41(11):911-20.


Hulsmans M, Geeraert B, Arnould T, Tsatsanis C, Holvoet P PPAR agonist-induced reduction of Mcp1 in atherosclerotic plaques of obese, insulin-resistant mice depends on adiponectin-induced Irak3 expression PloS one 2013, 8:e62253.

Colombaro V, Decleves AE, Jadot I, Voisin V, Giordano L, Habsch I, Nonclercq D, Flamion B, Caron N Inhibition of hyaluronan is protective against renal ischaemia-reperfusion injury. Nephrol Dial Transplant 2013, 28:2484-2493.

Decleves, A. , Pozdzik, A. , Baudoux, T. , Habsch, I. , De Prez, E. , Flamion, B. , Nortier, J. , Caron, N. CD44-positive cells and hyaluronan are a hallmark of a rat model of aristolochic acid nephropathy. J Cytol Histol 2013, 4: 186


Demine S, Michel S, Vannuvel K, Wanet A, Renard P, Arnould T Macroautophagy and Cell Responses Related to Mitochondrial Dysfunction, Lipid Metabolism and Unconventional Secretion of Proteins (Review). Cells 2012, 1(2):168-203.

De Pauw A, Demine S, Tejerina S, Dieu M, Delaive E, Kel A, Renard P, Raes M, Arnould T Mild mitochondrial uncoupling does not affect mitochondrial biogenesis but downregulates pyruvate carboxylase in adipocytes: role for triglyceride content reduction American journal of physiology Endocrinology and metabolism 2012, 302:E1123-1141.