Te-Din Daniel Huang

Molecular clinical microbiology


Pr Te-Din HuangProf. Te-Din Daniel Huang MD, PhD

CHU UCL Namur, Site Godinne, Department of Clinical Microbiology

Head of the National Reference Center for Antibiotic-Resistant Gram-Negative Bacilli

Head of the National Reference Center for Helicobacter pylori

Chairman of the Belgian National Antibiogram Committee

Member of the Institute of Experimental and Clinical Research (IREC), UCLouvain

Member of the Namur Research Pole in Infectiology (NaRePI)

ORCID | ResearchGate | LinkedIn

Expertise and research interests

Evaluation and development of in vitro diagnostic tools for the detection of antibiotic resistance markers in Gram-negatives and in H. pylori

Surveillance of antimicrobial resistance, phenotypic and molecular characterization of the resistance mechanisms  in Gram-negatives and in H. pylori

Exploration of new antibacterial drugs or strategies to overcome pandrug-resistant bacteria

Team member

PhD student: Pauline Rouzé, UCLouvain

Research projects

  • ONGOING Application of Targeted-Antibacterial-Plasmids against Antimicrobial Resistant Strains. Ongoing PhD thesis by Pauline Rouzé, UCLouvain. Under co-supervision by Prof. Te-Din Daniel Huang (promoter) and Prof. Pierre Bogaerts (co-promoter), CHU UCL Namur.  

   In collaboration with UNamur

  • The prevalence and the resistance mechanisms of colistin-resistant E. coli (COLREC) at the human-livestock interface in an One Health approach. Research collaboration between Prof. Benoît Muylkens, UNamur; Prof. Te-Din Daniel Huang, Prof. Pierre Bogaerts and Prof. Youri Glupczynski, CHU UCL Namur; Dr. Marc Saulmont, Arsia; Prof. Catherine Linard, UNamur (2018).
  • Improvement of identification of Capnocytophaga canimorsus by matrix-assisted laser desorption ionization-time of flight mass spectrometry using enriched database. Research collaboration between Prof. Francesco Renzi and Prof. Guy Cornelis, UNamur; Prof. Te-Din Daniel Huang, Prof. Pierre Bogaerts and Prof. Youri Glupczynski, CHU UCL Namur (2015).

Selected publications

Oliver A, Rojo-Molinero E, Arca-Suarez J, Beşli Y, Bogaerts P, Cantón R, Cimen C, Croughs PD, Denis O, Giske CG, Graells T, Daniel Huang TD, Iorga BI, Karatuna O, Kocsis B, Kronenberg A, López-Causapé C, Malhotra-Kumar S, Martínez LM, Mazzariol A, Meyer S, Naas T, Notermans DW, Oteo-Iglesias J, Pedersen T, Pirš M, Poeta P, Poirel L, Pournaras S, Sundsfjord A, Szabó D, Tambić-Andrašević A, Vatcheva-Dobrevska R, Vitkauskienė A, Jeannot K; ESGARS-ISARPAE members. Pseudomonas aeruginosa antimicrobial susceptibility profiles, resistance mechanisms and international clonal lineages: update from ESGARS-ESCMID/ISARPAE Group. Clin Microbiol Infect. 2023 Dec 29:S1198-743X(23)00634-1.

Benzaarate I, El Otmani F, Khazaz A, Timinouni M, Bourjilat F, Bogaerts P, Huang TD, Nayme K. Detection of Carbapenemase Encoding Gene and Resistance to Cefiderocol in Hospital and Community eXtensive Drug Resistance and Carbapenem-Resistant Pseudomonas aeruginosa Strains in Morocco. Foodborne Pathog Dis. 2023 Oct;20(10):460-466.

Maschietto C, Otto G, Rouzé P, Debortoli N, Bihin B, Nyinkeu L, Denis O, Huang TD, Mullier F, Bogaerts P, Degosserie J. Minimal requirements for ISO15189 validation and accreditation of three next generation sequencing procedures for SARS-CoV-2 surveillance in clinical setting. Sci Rep. 2023 Apr 28;13(1):6934.

Anantharajah A, Deltombe M, de Barsy M, Evrard S, Denis O, Bogaerts P, Hallin M, Miendje Deyi VY, Pierard D, Bruynseels P, Boelens J, Glupczynski Y, Huang TD. Characterization of hypervirulent Klebsiella pneumoniae isolates in Belgium. Eur J Clin Microbiol Infect Dis. 2022 May;41(5):859-865.

Deckers C, Soleimani R, Denis O, Bogaerts P, Berhin C, Rodríguez-Villalobos H, Descy J, Hallin M, Nonhoff C, Desmet S, Magerman K, Van den Abeele AM, Lissoir B, Matheeussen V, Vernelen K, Huang TD; Belgian National Antibiogram Committee. Multicentre interlaboratory analysis of routine susceptibility testing with a challenge panel of resistant strains. J Glob Antimicrob Resist. 2022 Mar;28:125-129.

Anantharajah A, Glupczynski Y, Hoebeke M, Bogaerts P, Declercq P, Denis O, Descy J, Floré K, Magerman K, Rodriguez-Villalobos H, Van den Abeele AM, Huang TD. Multicenter study of automated systems for colistin susceptibility testing. Eur J Clin Microbiol Infect Dis. 2021 Mar;40(3):575-579.

Bogaerts P, Berger AS, Evrard S, Huang TD. Comparison of two multiplex immunochromatographic assays for the rapid detection of major carbapenemases in Enterobacterales. J Antimicrob Chemother. 2020 Jun 1;75(6):1491-1494.

Huang TD, Melnik E, Bogaerts P, Evrard S, Glupczynski Y. Evaluation of the ePlex Blood Culture Identification Panels for Detection of Pathogens in Bloodstream Infections. J Clin Microbiol. 2019 Jan 30;57(2):e01597-18.

Huang TD, Bogaerts P, Berhin C, Hoebeke M, Bauraing C, Glupczynski Y; a multicentre study group. Increasing proportion of carbapenemase-producing Enterobacteriaceae and emergence of a MCR-1 producer through a multicentric study among hospital-based and private laboratories in Belgium from September to November 2015. Euro Surveill. 2017 May 11;22(19):30530.

Magnette A, Huang TD, Renzi F, Bogaerts P, Cornelis GR, Glupczynski Y. Improvement of Identification of Capnocytophaga canimorsus by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry using enriched database. Diagn Microbiol Infect Dis. 2016 Jan;84(1):12-15.

Huang TD, Bogaerts P, Ghilani E, Heinrichs A, Gavage P, Roisin S, Willems E, Verbruggen AM, Francart H, Denis O, Senterre JM, Glupczynski Y. Multicentre evaluation of the Check-Direct CPE® assay for direct screening of carbapenemase-producing Enterobacteriaceae from rectal swabs. J Antimicrob Chemother. 2015;70(6):1669-73. doi: 10.1093/jac/dkv009. Epub 2015 Jan 29. PMID: 25637518.

Contact

te-din.huang@chuuclnamur.uclouvain.be