NARILIS lunch seminar | Dr. Anchel de Jaime-Soguero, ULB, IRIBHM

We are pleased to invite you to a seminar given by

Dr. Anchel de Jaime-Soguero

Junior Group Leader at ULB, IRIBHM, Developmental Resilience laboratory

https://www.iribhm.org/research-labs/ade-jaime-soguero

His seminar is entitled:

Microenvironmental control of genome stability across early lineage specification: an unexpected role of morphogenetic signals

Human development relies on the correct replication, maintenance and segregation of our genetic blueprints. How these processes are monitored across embryonic lineages, and why genomic mosaicism varies during development remain unknown. Using pluripotent stem cells (PSCs), we identify that several patterning signals—including WNT, BMP, and FGF—converge into the modulation of DNA replication stress and damage during S-phase, which in turn controls chromosome segregation fidelity in mitosis. We show that the WNT and BMP signals protect from excessive origin firing, DNA damage and chromosome missegregation derived from stalled forks in pluripotency. Cell signalling control of chromosome segregation declines during lineage specification into the three germ layers, but re-emerges in neural progenitors, in which neurogenic factor FGF2 induces DNA replication stress-mediated chromosome missegregation during the onset of neurogenesis. These results highlight roles for morphogens and cellular identity in genome maintenance that contribute to somatic mosaicism during mammalian development. Currently, our group further explores mitigation strategies to reduce chromosome instability during long-term hPSC culture, and aims to map microenvironmental stress sources of mosaicism in human development using in vitro and in vivo models.

Invited by Prof. Patsy Renard, UNamur, URBC