NARILIS lunch seminar | Dr. Ludger JOHANNES, Institut Curie, Paris - CANCELLED

THIS SEMINAR IS CANCELLED !

We are pleased to invite you to a seminar given by

Dr. Ludger JOHANNES

Cellular and Chemical Biology Unit, Institut Curie, Paris

Leader of the team "Endocytic Trafficking and Intracellular Delivery"

His seminar is entitled:

GlycoSwitch — a novel signaling circuit to control endocytosis

It is commonly assumed that the glycan makeup of glycoproteins is final and static once these have reached the cell surface. Here, we challenge this notion by the discovery of a molecular switch — termed GlycoSwitch — that at the plasma membrane induces acute and reversible changes of glycan structure and arrangement in space. This leads to the binding and oligomerization of galectins that in interaction with glycosphingolipids drive the formation of tubular endocytic pits from which clathrin-independent endocytic carriers emerge for uptake and retrograde trafficking of the glycoproteins to the Golgi apparatus. Here, the glycoproteins are resialylated and secreted in a polarized manner to specialized areas of the cells, such as the leading edge in migrating cells. We are now exploring the structural, molecular, and pathophysiological aspects of the GlycoSwitch.

Invited by Prof. Henri-François Renard, UNamur, URBC