NAmur Research Institute for LIfe Sciences
Flora MUSUAMBA TSHINANU
Research topic
Short description
Prof. Flora Musuamba Tshinanu PharmD, PhD
UNamur, Faculty of medicine, Department of pharmacy, Research Unit in Clinical Pharmacology and Toxicology (URPC)
Vice Chair person at EMA Modelling and Simulation Working Party
Pharmacovigilance/Pharmacometrics expert at FAMPH
Research portal UNamur | ORCID | LinkedIn
Expertise and research interests
Group members
PhD student: Lisa Hanquet
Research projects
- ONGOING ERAMET project : Ecosystem for RApid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines.
- Pharmacokinetic modeling and control design for drug dosing. PhD thesis defended by Pauline Thémans on 07/07/2021. Under co-supervision by Prof. Joseph Winkin, UNamur, Department of mathematics (promoter) and Prof. Flora Musuamba, UNamur, Department of pharmacy (co-promoter).
Selected publications
Musuamba FT, Cheung SYA, Colin P, Davies EH, Barret JS, Pappalardo F, Chappell M, Dogne JM, Ceci A, Della Pasqua O, Rusten IS. Moving Toward a Question-Centric Approach for Regulatory Decision Making in the Context of Drug Assessment. Clin Pharmacol Ther. 2023 Jul;114(1):41-50.
Skottheim Rusten I, Musuamba FT. Scientific and regulatory evaluation of empirical pharmacometric models: An application of the risk informed credibility assessment framework. CPT Pharmacometrics Syst Pharmacol. 2021 Nov;10(11):1281-1296.
Musuamba FT, Skottheim Rusten I, Lesage R, Russo G, Bursi R, Emili L, Wangorsch G, Manolis E, Karlsson KE, Kulesza A, Courcelles E, Boissel JP, Rousseau CF, Voisin EM, Alessandrello R, Curado N, Dall'ara E, Rodriguez B, Pappalardo F, Geris L. Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility. CPT Pharmacometrics Syst Pharmacol. 2021 Aug;10(8):804-825.
Thémans P, Dauby N, Schrooyen L, Lebout F, Delforge M, Nasreddine R, Libois A, Payen MC, Konopnicki D, Wuillaume F, Lescrainier C, Verlinden V, Dogné JM, Hamdani J, Musuamba FT. Model informed dosing of hydroxycholoroquine in COVID-19 patients: Learnings from the recent experience, remaining uncertainties and gaps. Br J Clin Pharmacol. 2021 Feb;87(2):674-682.
Thémans P, Belkhir L, Dauby N, Yombi JC, De Greef J, Delongie KA, Vandeputte M, Nasreddine R, Wittebole X, Wuillaume F, Lescrainier C, Verlinden V, Kiridis S, Dogné JM, Hamdani J, Wallemacq P, Musuamba FT. Population Pharmacokinetics of Hydroxychloroquine in COVID-19 Patients: Implications for Dose Optimization. Eur J Drug Metab Pharmacokinet. 2020 Dec;45(6):703-713.
Musuamba FT, Bursi R, Manolis E, Karlsson K, Kulesza A, Courcelles E, Boissel JP, Lesage R, Crozatier C, Voisin EM, Rousseau CF, Marchal T, Alessandrello R, Geris L. Verifying and Validating Quantitative Systems Pharmacology and In Silico Models in Drug Development: Current Needs, Gaps, and Challenges. CPT Pharmacometrics Syst Pharmacol. 2020 Apr;9(4):195-197.
Nanga TM, Doan TTP, Marquet P, Musuamba FT. Toward a robust tool for pharmacokinetic-based personalization of treatment with tacrolimus in solid organ transplantation: A model-based meta-analysis approach. Br J Clin Pharmacol. 2019 Dec;85(12):2793-2823.
Thémans P, Marquet P, Winkin JJ, Musuamba FT. Towards a Generic Tool for Prediction of Meropenem Systemic and Infection-Site Exposure: A Physiologically Based Pharmacokinetic Model for Adult Patients with Pneumonia. Drugs R D. 2019 Jun;19(2):177-189.
Musuamba FT, Manolis E, Holford N, Cheung S, Friberg LE, Ogungbenro K, Posch M, Yates J, Berry S, Thomas N, Corriol-Rohou S, Bornkamp B, Bretz F, Hooker AC, Van der Graaf PH, Standing JF, Hay J, Cole S, Gigante V, Karlsson K, Dumortier T, Benda N, Serone F, Das S, Brochot A, Ehmann F, Hemmings R, Rusten IS. Advanced Methods for Dose and Regimen Finding During Drug Development: Summary of the EMA/EFPIA Workshop on Dose Finding (London 4-5 December 2014). CPT Pharmacometrics Syst Pharmacol. 2017 Jul;6(7):418-429.
Musuamba FT, Teutonico D, Maas HJ, Facius A, Yang S, Danhof M, Della Pasqua O. Prediction of disease progression, treatment response and dropout in chronic obstructive pulmonary disease (COPD). Pharm Res. 2015 Feb;32(2):617-27.
