NAmur Research Institute for LIfe Sciences
Lionel Pochet
Computer-aided and fragment-based drug design
Discovery of new therapeutic agents using computer-aided and fragment-based drug design approaches
Dr. Lionel Pochet PharmD, PhD
UNamur, Department of pharmacy
Member of the Namur Medicine & Drug Innovation Center (NAMEDIC)
Research portal UNamur | ORCID | ResearchGate | LinkedIn
Expertise and research interests
Dr. Lionel Pochet has a solid expertise on medicinal chemistry in general, and in the rational design and evaluation of new serine protease inhibitors, in particular, using computer-aided and fragment-based drug design approaches. During his research, he designed coumarin derivatives as covalent inhibitors. In the last decade, first during his postdoc and then, in collaboration with Prof. Marianne Fillet (ULiège), Prof. Raphaël Frédérick (UCLouvain) and Prof. Johan Wouters (UNamur), he was involved in the development of analytical methodologies in support of medicinal chemistry projects.
Group members
PhD students: Xavier Garcia Llinas and Amandine Traina
Research projects
- ONGOING Structure-based drug design and synthesis of selective small-molecular-weight inhibitors of FXIIa, an attractive target from the intrinsic coagulation cascade. Ongoing PhD thesis by Amandine Traina. Under co-supervision by Prof. Steve Lanners (promoter) and Dr. Lionel Pochet (co-promoter).
- ONGOING Design and synthesis of covalent disruptors to target the self-association of proteins. Ongoing PhD thesis by Xavier Garcia Llinas. Under co-supervision by Dr. Lionel Pochet (promoter) and Prof. Johan Wouters (co-promoter).
- . PhD thesis defended by Clara Davoine on 25/04/2023. Under co-supervision by Dr. Lionel Pochet, UNamur and Prof. Marianne Fillet, ULiège.
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. PhD thesis defended by François Simon on 18/12/2020. Under co-supervision by Prof. Steve Lanners (promoter) and Dr. Lionel Pochet (co-promoter)
- Development of electrophoretic methods for fragment screening and early metabolism studies: application to the discovery of antithrombotic drugs. PhD thesis defended by Elena Farcas on 27/04/2018. Under co-supervision by Prof. Marianne Fillet, ULiège (promoter) and Dr. Lionel Pochet, UNamur (co-promoter).
- Design, synthesis and evaluation of coagulation FXIIa, inhibitors as potential antithrombotic agents. PhD thesis defended by Charlotte Bouckaert on 16/05/2017. Under co-supervision by Dr. Lionel Pochet (promoter) and Prof. Jean-Michel Dogné (co-promoter).
Selected publications
Davoine C, Traina A, Evrard J, Lanners S, Fillet M, Pochet L. Coumarins as factor XIIa inhibitors: Potency and selectivity improvements using a fragment-based strategy. Eur J Med Chem. 2023 Jul 16;259:115636.
Davoine C, Pochet L, Fillet M. Advances in analytical technologies detecting and characterizing noncovalent interactions for fragment-based drug discovery. TrAC Trends in Analytical Chemistry, 2023 Volume 166, 117161.
Davoine C, Fillet M, Pochet L. Capillary electrophoresis as a fragment screening tool to cross-validate hits from chromogenic assay: Application to FXIIa. Talanta. 2021. Volume 226, 122163.
Davoine C, Bouckaert C, Fillet M, Pochet L. Factor XII/XIIa inhibitors: Their discovery, development, and potential indications. Eur J Med Chem. 2020 Aug 20;208:112753.
Ameryckx A, Pochet L, Wang G, Yildiz E, Saadi BE, Wouters J, Van Bambeke F, Frédérick R. Pharmacomodulations of the benzoyl-thiosemicarbazide scaffold reveal antimicrobial agents targeting d-alanyl-d-alanine ligase in bacterio. Eur J Med Chem. 2020 Aug 15;200:112444.
Farcaş E, Hanson J, Pochet L, Fillet M. Capillary electrophoretic mobility shift displacement assay for the assessment of weak drug-protein interactions. Anal Chim Acta. 2018 Nov 30;1034:214-222.
Farcaş E, Bouckaert C, Servais AC, Hanson J, Pochet L, Fillet M. Partial filling affinity capillary electrophoresis as a useful tool for fragment-based drug discovery: A proof of concept on thrombin. Anal Chim Acta. 2017 Sep 1;984:211-222.
Bouckaert C, Zhu S, Govers-Riemslag JWP, Depoorter M, Diamond SL, Pochet L. Discovery and assessment of water soluble coumarins as inhibitors of the coagulation contact pathway. Thromb Res. 2017 Jul 19;157:126-133.
Bouckaert C, Serra S, Rondelet G, Dolušić E, Wouters J, Dogné JM, Frédérick R, Pochet L. Synthesis, evaluation and structure-activity relationship of new 3-carboxamide coumarins as FXIIa inhibitors. Eur J Med Chem. 2016 Jan 16;110:181-194.
