NAmur Research Institute for LIfe Sciences
Completed PhD theses in the area of MEDICINAL CHEMISTRY
Clickable mannose analogues: powerful tool to label bacterial cell wall by Metabolic Glycoengineering and Synthesize sugar nucleotide for antibodies functionalization
PhD thesis defended by Marine LACRITICK (Prof. Stéphane VINCENT) - 25/11/2024
Synthesis of beta-lactams for the electrochemical detection of bacterial antibioresistance
PhD thesis defended by Arnaud BEAUFAYS (Prof. Stéphane VINCENT) - 25/10/2023
Identification, characterization, and optimization of fragment hits against coagulation factor XIIa supported by affinity capillary electrophoresis and biochemical assay
PhD thesis defended by Clara DAVOINE (Prof. Lionel POCHET & Prof. Marianne FILLET) - 25/04/2023
Characterization of the oligometric interface of Lactate Dehydrogenase-B (LDH-B) through crystallographic and molecular dynamics approaches
PhD thesis defended by Mégane VAN GYSEL (Prof. Johan WOUTERS) - 20/02/2023
Development of carbohydrate analogues as mechanistic probe for the characterization of galactofuranoside hydrolase
PhD thesis defended by Loïc CHENE (Prof. Stéphane VINCENT) - 25/01/2023
Plasticity of human indoleamine-2,3-dioxygenases 1 and 2 through a structural approach combining crystallography and Molecular Dynamics studies
PhD thesis defended by Manon MIRGAUX (Prof. Johan WOUTERS) - 16/11/2022
Synthesis of Heptose mimetics as inhibitors of bacterial enzymes or modulators of inflammation
PhD thesis defended by Jun CAO (Prof. Stéphane VINCENT) - 20/10/2022
Biophysical and enzymological exploration of Mycobacterium tuberculosis phosphoserine phosphatase SerB2 self-assembly and regulation by L-serine
PhD thesis defended by Elise PIERSON (Prof. Johan WOUTERS) - 03/10/2022
Site-selective functionalisation of antibody Glycans for biomedical applications
PhD thesis defended by Léa CHARTIER (Prof. Stéphane VINCENT) - 01/07/2022
Differentiation and Encapsulation of ß-like cells for the treatment of type 1 Diabetes Mellitus
PhD thesis defended by Myriam NEUMANN (Prof. Bao-Lian SU and Prof. Thierry ARNOULD) - 27/06/2022
Small molecules as therapeutic options in Parkinson’s disease: case of modulators of UCH-L1 and GLP-1 receptor
PhD thesis defended by Kalina MAMBOURG (Prof. Johan WOUTERS) - 31/03/2022
Structural and inhibition study of phosphoserine phosphatase (SerB2) from Mycobacterium tuberculosis
PhD thesis defended by Marie HAUFROID (Prof. Johan WOUTERS) - 25/03/2022
Towards the total synthesis of momilactones: asymmetric Diels-Alder reactions of quinones and sulfinylquinones for the synthesis of terpenes
PhD thesis defended by Loïc JEANMART (Prof. Steve LANNERS) - 08/12/2021
Synthesis and biological evaluations of novel pillar[5]arene conjugates
PhD thesis defended by Whenzhang CHEN (Prof. Stéphane VINCENT) - 27/10/2021
Drug-drug cocrystallization or salt formation as an alternative to combination drugs: a case study on clofazimine
PhD thesis defended by Laurie BODART (Prof. Johan WOUTERS) - 20/09/2021
Design and Synthesis of Phenylguanidine-Based and Benzamidine-Based FXIIa Inhibitors
PhD thesis defended by François SIMON (Prof. Steve LANNERS) - 18/12/2020
Synthesis and characterization of novel glycogold nanoparticles as antibiofilm and antibacterial agents
PhD thesis defended by Tao WANG (Prof. Stéphane VINCENT) - 28/10/2020
Characterization of the anticancer properties of new hydroxamate-based histone deactylase inhibitors
PhD thesis defended by Manon LERNOUX (Prof. Carine MICHIELS) - 22/11/2019
Potentialisation des chimiothérapies conventionnelles par la découverte de chimiosensibilisants actifs en hypoxie ou agissant sur la protéine VKORC1
PhD thesis defended by Sébastien MARX (Prof. Johan WOUTERS) - 25/10/2019
Synthesis of Heptose Mono- and Bisphosphate Analogues as Modulators of the Bacterial Innate Immunity and Inhibitors of the Bacterial Lipopolysaccharide
PhD thesis defended by Lina LIANG (Prof. Stéphane VINCENT) - 24/10/2019
Structural and functional approach of the first enzyme of the serine synthesis pathway: PHGDH a potential target for cancer treatment
PhD thesis defended by Quentin THEMANS (Prof. Johan WOUTERS) - 18/10/2019
Structural and functional characterization of the transmembrane protein 45A (TMEM45A) in triple negative breast cancers
PhD thesis defended by Thomas DAL MASO (Prof. Johan WOUTERS) - 04/10/2019
Influence des lipides de la membrane plasmique sur la structure et la fonction du récepteur opioïde µ par dynamique moléculaire gros grains
PhD thesis defended by Marie-Ange ANGLADON (Prof. Daniel VERCAUTEREN) - 01/07/2019
Photochromic multicomponent crystalline materials based on N-salicylideneanilines
PhD thesis defended by Andrea CARLETTA (Prof. Johan WOUTERS) - 25/04/2019
Synthesis of unprecedented electron-deficient exo-glycals targeting the Mycobacterium tuberculosis cell wall
PhD thesis defended by Christophe FREDERIC (Prof. Stéphane VINCENT) - 19/12/2018
Development of new debenzylative cyclization reactions and de novo synthesis of difluorinated glycomimetics
PhD thesis defended by Julien DELBROUCK (Prof. Stéphane VINCENT) - 20/11/2018
Synthetic derivatives of natural polyphenols targeting the mycobacterial cell wall
PhD thesis defended by Sydney VILLAUME (Prof. Stéphane VINCENT) - 15/10/2018
Synthèse de gamma-lactones et gamma-lactames beta-substituées en flux continu
PhD thesis defended by Stéphane COLLIN (Prof. Steve LANNERS) - 06/04/2018
Etude structurale d’imines et de phtalimides obtenus par mécanosynthèse
PhD thesis defended by Jean DUBOIS (Prof. Johan WOUTERS) - 24/11/2017
Discovery of novel inhibitors targeting the mycobacterial cell wall
PhD thesis defended by Jian FU (Prof. Stéphane VINCENT) - 06/10/2017
